Class Level Information	
Class	Levels	Values	
Treatment_group	4	1.Naltrexone + CBI 2.Naltrexone 3.CBI 4.Neither	

Number of Observations Read	721	
Number of Observations Used	721	

Source	DF	Sum of Squares	Mean Square	F Value	Pr > F	
Model	3	6.0253119	2.0084373	3.34	0.0189	
Error	717	431.0806211	0.6012282			
Corrected Total	720	437.1059330				

R-Square	Coeff Var	Root MSE	ldpd Mean	
0.013785	71.38636	0.775389	1.086187	

Source	DF	Type I SS	Mean Square	F Value	Pr > F	
Treatment_group	3	6.02531193	2.00843731	3.34	0.0189	

Source	DF	Type III SS	Mean Square	F Value	Pr > F	
Treatment_group	3	6.02531193	2.00843731	3.34	0.0189	

Treatment_group	ldpd LSMEAN	Standard Error	Pr > |t|	LSMEAN Number	
1.Naltrexone + CBI	1.04179294	0.05929548	<.0001	1	
2.Naltrexone	1.04066247	0.06018186	<.0001	2	
3.CBI	1.00911463	0.05731841	<.0001	3	
4.Neither	1.23172118	0.05469173	<.0001	4	

Least Squares Means for effect Treatment_group
Pr > |t| for H0: LSMean(i)=LSMean(j)

Dependent Variable: ldpd	
i/j	1	2	3	4	
1		0.9893	0.6920	0.0188	
2	0.9893		0.7044	0.0191	
3	0.6920	0.7044		0.0051	
4	0.0188	0.0191	0.0051		

Treatment_group	ldpd LSMEAN	95% Confidence Limits	
1.Naltrexone + CBI	1.041793	0.925379	1.158206	
2.Naltrexone	1.040662	0.922509	1.158816	
3.CBI	1.009115	0.896583	1.121647	
4.Neither	1.231721	1.124346	1.339096	

Least Squares Means for Effect Treatment_group	
i	j	Difference Between Means	95% Confidence Limits for LSMean(i)-LSMean(j)	
1	2	0.001130	-0.164738	0.166999	
1	3	0.032678	-0.129234	0.194590	
1	4	-0.189928	-0.348300	-0.031557	
2	3	0.031548	-0.131620	0.194716	
2	4	-0.191059	-0.350714	-0.031404	
3	4	-0.222607	-0.378147	-0.067066	

Note:	To ensure overall protection level, only probabilities associated with pre-planned comparisons should be used.	

Treatment_group	ldpd LSMEAN	Standard Error	Pr > |t|	LSMEAN Number	
1.Naltrexone + CBI	1.04179294	0.05929548	<.0001	1	
2.Naltrexone	1.04066247	0.06018186	<.0001	2	
3.CBI	1.00911463	0.05731841	<.0001	3	
4.Neither	1.23172118	0.05469173	<.0001	4	

Least Squares Means for effect Treatment_group
Pr > |t| for H0: LSMean(i)=LSMean(j)

Dependent Variable: ldpd	
i/j	1	2	3	4	
1		1.0000	1.0000	0.1129	
2	1.0000		1.0000	0.1144	
3	1.0000	1.0000		0.0306	
4	0.1129	0.1144	0.0306		

Treatment_group	ldpd LSMEAN	95% Confidence Limits	
1.Naltrexone + CBI	1.041793	0.925379	1.158206	
2.Naltrexone	1.040662	0.922509	1.158816	
3.CBI	1.009115	0.896583	1.121647	
4.Neither	1.231721	1.124346	1.339096	

Least Squares Means for Effect Treatment_group	
i	j	Difference Between Means	Simultaneous 95% Confidence Limits for LSMean(i)-LSMean(j)	
1	2	0.001130	-0.222384	0.224645	
1	3	0.032678	-0.185505	0.250862	
1	4	-0.189928	-0.403340	0.023484	
2	3	0.031548	-0.188328	0.251423	
2	4	-0.191059	-0.406200	0.024083	
3	4	-0.222607	-0.432204	-0.013009	

Treatment_group	ldpd LSMEAN	Standard Error	Pr > |t|	LSMEAN Number	
1.Naltrexone + CBI	1.04179294	0.05929548	<.0001	1	
2.Naltrexone	1.04066247	0.06018186	<.0001	2	
3.CBI	1.00911463	0.05731841	<.0001	3	
4.Neither	1.23172118	0.05469173	<.0001	4	

Least Squares Means for effect Treatment_group
Pr > |t| for H0: LSMean(i)=LSMean(j)

Dependent Variable: ldpd	
i/j	1	2	3	4	
1		1.0000	0.9789	0.0870	
2	1.0000		0.9814	0.0881	
3	0.9789	0.9814		0.0261	
4	0.0870	0.0881	0.0261		

Treatment_group	ldpd LSMEAN	95% Confidence Limits	
1.Naltrexone + CBI	1.041793	0.925379	1.158206	
2.Naltrexone	1.040662	0.922509	1.158816	
3.CBI	1.009115	0.896583	1.121647	
4.Neither	1.231721	1.124346	1.339096	

Least Squares Means for Effect Treatment_group	
i	j	Difference Between Means	Simultaneous 95% Confidence Limits for LSMean(i)-LSMean(j)	
1	2	0.001130	-0.216421	0.218682	
1	3	0.032678	-0.179684	0.245040	
1	4	-0.189928	-0.397646	0.017790	
2	3	0.031548	-0.182461	0.245557	
2	4	-0.191059	-0.400460	0.018343	
3	4	-0.222607	-0.426612	-0.018601	

Treatment_group	ldpd LSMEAN	Standard Error	Pr > |t|	LSMEAN Number	
1.Naltrexone + CBI	1.04179294	0.05929548	<.0001	1	
2.Naltrexone	1.04066247	0.06018186	<.0001	2	
3.CBI	1.00911463	0.05731841	<.0001	3	
4.Neither	1.23172118	0.05469173	<.0001	4	

Least Squares Means for effect Treatment_group
Pr > |t| for H0: LSMean(i)=LSMean(j)

Dependent Variable: ldpd	
i/j	1	2	3	4	
1		1.0000	0.9842	0.1371	
2	1.0000		0.9861	0.1385	
3	0.9842	0.9861		0.0491	
4	0.1371	0.1385	0.0491		

Treatment_group	ldpd LSMEAN	95% Confidence Limits	
1.Naltrexone + CBI	1.041793	0.925379	1.158206	
2.Naltrexone	1.040662	0.922509	1.158816	
3.CBI	1.009115	0.896583	1.121647	
4.Neither	1.231721	1.124346	1.339096	

Least Squares Means for Effect Treatment_group	
i	j	Difference Between Means	Simultaneous 95% Confidence Limits for LSMean(i)-LSMean(j)	
1	2	0.001130	-0.235610	0.237871	
1	3	0.032678	-0.198415	0.263771	
1	4	-0.189928	-0.415968	0.036111	
2	3	0.031548	-0.201338	0.264433	
2	4	-0.191059	-0.418930	0.036813	
3	4	-0.222607	-0.444606	-0.000608	

Treatment_group	ldpd LSMEAN	Standard Error	H0:LSMEAN=0	H0:LSMean=Control	
			Pr > |t|	Pr > |t|	
1.Naltrexone + CBI	1.04179294	0.05929548	<.0001	0.0508	
2.Naltrexone	1.04066247	0.06018186	<.0001	0.0514	
3.CBI	1.00911463	0.05731841	<.0001	0.0143	
4.Neither	1.23172118	0.05469173	<.0001		

Treatment_group	ldpd LSMEAN	95% Confidence Limits	
1.Naltrexone + CBI	1.041793	0.925379	1.158206	
2.Naltrexone	1.040662	0.922509	1.158816	
3.CBI	1.009115	0.896583	1.121647	
4.Neither	1.231721	1.124346	1.339096	

Least Squares Means for Effect Treatment_group	
i	j	Difference Between Means	Simultaneous 95% Confidence Limits for LSMean(i)-LSMean(j)	
1	4	-0.189928	-0.380330	0.000473	
2	4	-0.191059	-0.383004	0.000886	
3	4	-0.222607	-0.409605	-0.035608	

Obs	Effect	Dependent	i	j	LowerCL	Difference	UpperCL	Treatment_group	
1	Treatment_group	ldpd	1	2	-0.164738	0.001130	0.166999	1.Naltrexone + CBI	
2	Treatment_group	ldpd	1	3	-0.129234	0.032678	0.194590	1.Naltrexone + CBI	
3	Treatment_group	ldpd	1	4	-0.348300	-0.189928	-0.031557	1.Naltrexone + CBI	
4	Treatment_group	ldpd	2	3	-0.131620	0.031548	0.194716	2.Naltrexone	
5	Treatment_group	ldpd	2	4	-0.350714	-0.191059	-0.031404	2.Naltrexone	
6	Treatment_group	ldpd	3	4	-0.378147	-0.222607	-0.067066	3.CBI	
7	Treatment_group	ldpd	1	2	-0.222384	0.001130	0.224645	1.Naltrexone + CBI	
8	Treatment_group	ldpd	1	3	-0.185505	0.032678	0.250862	1.Naltrexone + CBI	
9	Treatment_group	ldpd	1	4	-0.403340	-0.189928	0.023484	1.Naltrexone + CBI	
10	Treatment_group	ldpd	2	3	-0.188328	0.031548	0.251423	2.Naltrexone	
11	Treatment_group	ldpd	2	4	-0.406200	-0.191059	0.024083	2.Naltrexone	
12	Treatment_group	ldpd	3	4	-0.432204	-0.222607	-0.013009	3.CBI	
13	Treatment_group	ldpd	1	2	-0.216421	0.001130	0.218682	1.Naltrexone + CBI	
14	Treatment_group	ldpd	1	3	-0.179684	0.032678	0.245040	1.Naltrexone + CBI	
15	Treatment_group	ldpd	1	4	-0.397646	-0.189928	0.017790	1.Naltrexone + CBI	
16	Treatment_group	ldpd	2	3	-0.182461	0.031548	0.245557	2.Naltrexone	
17	Treatment_group	ldpd	2	4	-0.400460	-0.191059	0.018343	2.Naltrexone	
18	Treatment_group	ldpd	3	4	-0.426612	-0.222607	-0.018601	3.CBI	
19	Treatment_group	ldpd	1	2	-0.235610	0.001130	0.237871	1.Naltrexone + CBI	
20	Treatment_group	ldpd	1	3	-0.198415	0.032678	0.263771	1.Naltrexone + CBI	
21	Treatment_group	ldpd	1	4	-0.415968	-0.189928	0.036111	1.Naltrexone + CBI	
22	Treatment_group	ldpd	2	3	-0.201338	0.031548	0.264433	2.Naltrexone	
23	Treatment_group	ldpd	2	4	-0.418930	-0.191059	0.036813	2.Naltrexone	
24	Treatment_group	ldpd	3	4	-0.444606	-0.222607	-0.000608	3.CBI	
25	Treatment_group	ldpd	1	4	-0.380330	-0.189928	0.000473	1.Naltrexone + CBI	
26	Treatment_group	ldpd	2	4	-0.383004	-0.191059	0.000886	2.Naltrexone	
27	Treatment_group	ldpd	3	4	-0.409605	-0.222607	-0.035608	3.CBI	

Obs	_Treatment_group	Adjustment	
1	2.Naltrexone	None	
2	3.CBI	None	
3	4.Neither	None	
4	3.CBI	None	
5	4.Neither	None	
6	4.Neither	None	
7	2.Naltrexone	Bonf	
8	3.CBI	Bonf	
9	4.Neither	Bonf	
10	3.CBI	Bonf	
11	4.Neither	Bonf	
12	4.Neither	Bonf	
13	2.Naltrexone	Tukey	
14	3.CBI	Tukey	
15	4.Neither	Tukey	
16	3.CBI	Tukey	
17	4.Neither	Tukey	
18	4.Neither	Tukey	
19	2.Naltrexone	Scheffe	
20	3.CBI	Scheffe	
21	4.Neither	Scheffe	
22	3.CBI	Scheffe	
23	4.Neither	Scheffe	
24	4.Neither	Scheffe	
25	4.Neither	Dunnett	
26	4.Neither	Dunnett	
27	4.Neither	Dunnett	

Class Level Information	
Class	Levels	Values	
treatment	8	Nx_CBI_Ac Nx_CBI_Pl Nx__no_Ac Nx__no_Pl Pl_CBI_Ac Pl_CBI_Pl Pl__no_Ac Pl__no_Pl	

Number of Observations Read	1226	
Number of Observations Used	1147	

Source	DF	Sum of Squares	Mean Square	F Value	Pr > F	
Model	7	1326.51293	189.50185	2.28	0.0264	
Error	1139	94771.78349	83.20613			
Corrected Total	1146	96098.29643				

R-Square	Coeff Var	Root MSE	dd4 Mean	
0.013804	128.8026	9.121739	7.081953	

Source	DF	Type I SS	Mean Square	F Value	Pr > F	
treatment	7	1326.512931	189.501847	2.28	0.0264	

Source	DF	Type III SS	Mean Square	F Value	Pr > F	
treatment	7	1326.512931	189.501847	2.28	0.0264	

Source	DF	Sum of Squares	Mean Square	F Value	Pr > F	
Model	7	14.0817843	2.0116835	3.10	0.0030	
Error	1139	738.9537227	0.6487741			
Corrected Total	1146	753.0355070				

R-Square	Coeff Var	Root MSE	ldpd Mean	
0.018700	117.9697	0.805465	0.682773	

Source	DF	Type I SS	Mean Square	F Value	Pr > F	
treatment	7	14.08178428	2.01168347	3.10	0.0030	

Source	DF	Type III SS	Mean Square	F Value	Pr > F	
treatment	7	14.08178428	2.01168347	3.10	0.0030	

treatment	dd4 LSMEAN	Standard Error	Pr > |t|	LSMEAN Number	
Nx_CBI_Ac	6.07692308	0.76279818	<.0001	1	
Nx_CBI_Pl	7.00680272	0.75234839	<.0001	2	
Nx__no_Ac	6.32142857	0.77092769	<.0001	3	
Nx__no_Pl	6.23076923	0.76279818	<.0001	4	
Pl_CBI_Ac	7.36111111	0.76014496	<.0001	5	
Pl_CBI_Pl	6.15862069	0.75751923	<.0001	6	
Pl__no_Ac	8.27972028	0.76279818	<.0001	7	
Pl__no_Pl	9.23239437	0.76547937	<.0001	8	

Least Squares Means for effect treatment
Pr > |t| for H0: LSMean(i)=LSMean(j)

Dependent Variable: dd4	
i/j	1	2	3	4	5	6	7	8	
1		0.3856	0.8217	0.8866	0.2333	0.9394	0.0414	0.0036	
2	0.3856		0.5247	0.4690	0.7405	0.4271	0.2350	0.0383	
3	0.8217	0.5247		0.9334	0.3371	0.8803	0.0712	0.0075	
4	0.8866	0.4690	0.9334		0.2941	0.9465	0.0578	0.0056	
5	0.2333	0.7405	0.3371	0.2941		0.2627	0.3938	0.0831	
6	0.9394	0.4271	0.8803	0.9465	0.2627		0.0487	0.0044	
7	0.0414	0.2350	0.0712	0.0578	0.3938	0.0487		0.3782	
8	0.0036	0.0383	0.0075	0.0056	0.0831	0.0044	0.3782		

treatment	ldpd LSMEAN	Standard Error	Pr > |t|	LSMEAN Number	
Nx_CBI_Ac	0.61875721	0.06735638	<.0001	1	
Nx_CBI_Pl	0.60996130	0.06643365	<.0001	2	
Nx__no_Ac	0.58608369	0.06807423	<.0001	3	
Nx__no_Pl	0.63425352	0.06735638	<.0001	4	
Pl_CBI_Ac	0.67706806	0.06712210	<.0001	5	
Pl_CBI_Pl	0.60117362	0.06689024	<.0001	6	
Pl__no_Ac	0.83917414	0.06735638	<.0001	7	
Pl__no_Pl	0.89840884	0.06759313	<.0001	8	

Least Squares Means for effect treatment
Pr > |t| for H0: LSMean(i)=LSMean(j)

Dependent Variable: ldpd	
i/j	1	2	3	4	5	6	7	8	
1		0.9259	0.7330	0.8708	0.5399	0.8531	0.0208	0.0035	
2	0.9259		0.8018	0.7974	0.4775	0.9258	0.0156	0.0024	
3	0.7330	0.8018		0.6151	0.3414	0.8744	0.0083	0.0012	
4	0.8708	0.7974	0.6151		0.6526	0.7275	0.0317	0.0057	
5	0.5399	0.4775	0.3414	0.6526		0.4234	0.0885	0.0203	
6	0.8531	0.9258	0.8744	0.7275	0.4234		0.0123	0.0018	
7	0.0208	0.0156	0.0083	0.0317	0.0885	0.0123		0.5349	
8	0.0035	0.0024	0.0012	0.0057	0.0203	0.0018	0.5349		

Note:	To ensure overall protection level, only probabilities associated with pre-planned comparisons should be used.	

P-Value Adjustment Information	
P-Value Adjustment	Bonferroni	
P-Value Adjustment	Stepdown Bonferroni	
P-Value Adjustment	Hochberg	
P-Value Adjustment	Hommel	
P-Value Adjustment	False Discovery Rate	
P-Value Adjustment	Dependent FDR	

p-Values	
Test	Raw	Bonferroni	Stepdown Bonferroni	Hochberg	Hommel	False Discovery Rate	Dependent FDR	
1	0.3856	1.0000	1.0000	0.9465	0.9465	0.7114	1.0000	
2	0.8217	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
3	0.8866	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
4	0.2333	1.0000	1.0000	0.9465	0.9465	0.5484	1.0000	
5	0.9394	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
6	0.0414	1.0000	1.0000	0.9465	0.9465	0.1363	0.6287	
7	0.0036	0.1999	0.1856	0.1856	0.1678	0.0400	0.1844	
8	0.5247	1.0000	1.0000	0.9465	0.9465	0.7956	1.0000	
9	0.4690	1.0000	1.0000	0.9465	0.9465	0.7640	1.0000	
10	0.7405	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
11	0.4271	1.0000	1.0000	0.9465	0.9465	0.7248	1.0000	
12	0.2350	1.0000	1.0000	0.9465	0.9465	0.5484	1.0000	
13	0.0383	1.0000	1.0000	0.9465	0.9465	0.1342	0.6188	
14	0.9334	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
15	0.3371	1.0000	1.0000	0.9465	0.9465	0.6829	1.0000	
16	0.8803	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
17	0.0712	1.0000	1.0000	0.9465	0.9465	0.1995	0.9198	
18	0.0075	0.4189	0.3591	0.3591	0.3292	0.0465	0.2147	
19	0.2941	1.0000	1.0000	0.9465	0.9465	0.6335	1.0000	
20	0.9465	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
21	0.0578	1.0000	1.0000	0.9465	0.9465	0.1703	0.7852	
22	0.0056	0.3117	0.2783	0.2783	0.2505	0.0401	0.1849	
23	0.2627	1.0000	1.0000	0.9465	0.9465	0.5885	1.0000	
24	0.3938	1.0000	1.0000	0.9465	0.9465	0.7114	1.0000	
25	0.0831	1.0000	1.0000	0.9465	0.9465	0.2215	1.0000	
26	0.0487	1.0000	1.0000	0.9465	0.9465	0.1516	0.6991	
27	0.0044	0.2460	0.2240	0.2240	0.2021	0.0401	0.1849	
28	0.3782	1.0000	1.0000	0.9465	0.9465	0.7114	1.0000	
29	0.9259	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
30	0.7330	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
31	0.8708	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
32	0.5399	1.0000	1.0000	0.9465	0.9465	0.7956	1.0000	
33	0.8531	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
34	0.0208	1.0000	0.8965	0.8965	0.7922	0.0834	0.3846	
35	0.0035	0.1932	0.1829	0.1829	0.1656	0.0400	0.1844	
36	0.8018	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
37	0.7974	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
38	0.4775	1.0000	1.0000	0.9465	0.9465	0.7640	1.0000	
39	0.9258	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
40	0.0156	0.8711	0.7000	0.7000	0.6067	0.0726	0.3348	
41	0.0024	0.1340	0.1292	0.1292	0.1172	0.0400	0.1844	
42	0.6151	1.0000	1.0000	0.9465	0.9465	0.8832	1.0000	
43	0.3414	1.0000	1.0000	0.9465	0.9465	0.6829	1.0000	
44	0.8744	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
45	0.0083	0.4667	0.3917	0.3917	0.3584	0.0467	0.2152	
46	0.0012	0.0652	0.0652	0.0652	0.0607	0.0400	0.1844	
47	0.6526	1.0000	1.0000	0.9465	0.9465	0.9137	1.0000	
48	0.7275	1.0000	1.0000	0.9465	0.9465	0.9465	1.0000	
49	0.0317	1.0000	1.0000	0.9465	0.9465	0.1182	0.5452	
50	0.0057	0.3207	0.2806	0.2806	0.2577	0.0401	0.1849	
51	0.4234	1.0000	1.0000	0.9465	0.9465	0.7248	1.0000	
52	0.0885	1.0000	1.0000	0.9465	0.9465	0.2253	1.0000	
53	0.0203	1.0000	0.8942	0.8942	0.7723	0.0834	0.3846	
54	0.0123	0.6892	0.5662	0.5662	0.5046	0.0627	0.2889	
55	0.0018	0.1019	0.1000	0.1000	0.0909	0.0400	0.1844	
56	0.5349	1.0000	1.0000	0.9465	0.9465	0.7956	1.0000	

Class Level Information	
Class	Levels	Values	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
ACAMPROSATE	2	0 1	

Number of Observations Read	721	
Number of Observations Used	721	

Source	DF	Sum of Squares	Mean Square	F Value	Pr > F	
Model	7	6.3334835	0.9047834	1.50	0.1648	
Error	713	430.7724495	0.6041689			
Corrected Total	720	437.1059330				

R-Square	Coeff Var	Root MSE	ldpd Mean	
0.014490	71.56073	0.777283	1.086187	

Source	DF	Type I SS	Mean Square	F Value	Pr > F	
ACAMPROSATE	1	0.00374039	0.00374039	0.01	0.9373	
NALTREXONE	1	1.27876310	1.27876310	2.12	0.1462	
NALTREXON*ACAMPROSAT	1	0.19469054	0.19469054	0.32	0.5704	
THERAPY	1	2.51124115	2.51124115	4.16	0.0418	
THERAPY*ACAMPROSATE	1	0.06325160	0.06325160	0.10	0.7464	
NALTREXONE*THERAPY	1	2.27763966	2.27763966	3.77	0.0526	
NALTRE*THERAP*ACAMPR	1	0.00415708	0.00415708	0.01	0.9339	

Source	DF	Type III SS	Mean Square	F Value	Pr > F	
ACAMPROSATE	1	0.00156840	0.00156840	0.00	0.9594	
NALTREXONE	1	1.12312268	1.12312268	1.86	0.1732	
NALTREXON*ACAMPROSAT	1	0.24625741	0.24625741	0.41	0.5234	
THERAPY	1	2.20196009	2.20196009	3.64	0.0567	
THERAPY*ACAMPROSATE	1	0.06358572	0.06358572	0.11	0.7457	
NALTREXONE*THERAPY	1	2.27637873	2.27637873	3.77	0.0526	
NALTRE*THERAP*ACAMPR	1	0.00415708	0.00415708	0.01	0.9339	

NALTREXONE	THERAPY	ACAMPROSATE	ldpd LSMEAN	
0	0	0	1.22667361	
0	0	1	1.23713301	
0	1	0	0.97944017	
0	1	1	1.03721065	
1	0	0	1.06703827	
1	0	1	1.01298416	
1	1	0	1.05487425	
1	1	1	1.02886374	

NALTREXONE	THERAPY	ldpd LSMEAN	Standard Error	Pr > |t|	
0	0	1.23190331	0.05485860	<.0001	
0	1	1.00832541	0.05747987	<.0001	
1	0	1.04001122	0.06034639	<.0001	
1	1	1.04186899	0.05944134	<.0001	

NALTREXONE*THERAPY Effect Sliced by THERAPY for ldpd	
THERAPY	DF	Sum of Squares	Mean Square	F Value	Pr > F	
0	1	3.344843	3.344843	5.54	0.0189	
1	1	0.099426	0.099426	0.16	0.6851	

NALTREXONE*THERAPY Effect Sliced by NALTREXONE for ldpd	
NALTREXONE	DF	Sum of Squares	Mean Square	F Value	Pr > F	
0	1	4.783576	4.783576	7.92	0.0050	
1	1	0.000291	0.000291	0.00	0.9825	

Parameter	Estimate	Standard Error	t Value	Pr > |t|	95% Confidence Limits	
Active vs. placebo naltrexone on CBI	0.03354358	0.08268741	0.41	0.6851	-0.12879635	0.19588351	
Active vs. placebo naltrexone, no CBI	-0.19189209	0.08155460	-2.35	0.0189	-0.35200796	-0.03177623	
CBI vs. no CBI on naltrexone	0.00185778	0.08470513	0.02	0.9825	-0.16444352	0.16815908	
CBI vs. no CBI on placebo naltrexone	-0.22357790	0.07945692	-2.81	0.0050	-0.37957540	-0.06758040	

P-Value Adjustment Information	
P-Value Adjustment	Bonferroni	
P-Value Adjustment	Stepdown Bonferroni	
P-Value Adjustment	Hochberg	
P-Value Adjustment	Hommel	
P-Value Adjustment	False Discovery Rate	

p-Values	
Test	Raw	Bonferroni	Stepdown Bonferroni	Hochberg	Hommel	False Discovery Rate	
1	0.6851	1.0000	1.0000	0.9825	0.9825	0.9135	
2	0.0189	0.0756	0.0567	0.0567	0.0567	0.0378	
3	0.9825	1.0000	1.0000	0.9825	0.9825	0.9825	
4	0.0050	0.0200	0.0200	0.0200	0.0200	0.0200	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1383 1382 1380 1379 1378 1377 1376 1375 1374 1373 1371 1370 1369 1368 1367 1366 1365 1364 1363 1361 1360 1359 1358 1357 1355 1354 1353 1352 1351 1350 1349 1347 1346 1345 1344 1343 1342 1341 1339 1338 1337 1336 1335 1334 1333 1332 1331 1329 1328 1327 ...	
NALTREXONE	2	1 0	
THERAPY	2	1 0	
month	4	4 3 2 1	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	1			
Prm3	NALTREXONE	0			
Prm4	THERAPY		1		
Prm5	THERAPY		0		
Prm6	NALTREXONE*THERAPY	1	1		
Prm7	NALTREXONE*THERAPY	1	0		
Prm8	NALTREXONE*THERAPY	0	1		
Prm9	NALTREXONE*THERAPY	0	0		
Prm10	month			4	
Prm11	month			3	
Prm12	month			2	
Prm13	month			1	
Prm14	NALTREXONE*month	1		4	
Prm15	NALTREXONE*month	1		3	
Prm16	NALTREXONE*month	1		2	
Prm17	NALTREXONE*month	1		1	
Prm18	NALTREXONE*month	0		4	
Prm19	NALTREXONE*month	0		3	
Prm20	NALTREXONE*month	0		2	
Prm21	NALTREXONE*month	0		1	
Prm22	THERAPY*month		1	4	
Prm23	THERAPY*month		1	3	
Prm24	THERAPY*month		1	2	
Prm25	THERAPY*month		1	1	
Prm26	THERAPY*month		0	4	
Prm27	THERAPY*month		0	3	
Prm28	THERAPY*month		0	2	
Prm29	THERAPY*month		0	1	
Prm30	NALTRE*THERAPY*month	1	1	4	
Prm31	NALTRE*THERAPY*month	1	1	3	
Prm32	NALTRE*THERAPY*month	1	1	2	
Prm33	NALTRE*THERAPY*month	1	1	1	
Prm34	NALTRE*THERAPY*month	1	0	4	
Prm35	NALTRE*THERAPY*month	1	0	3	
Prm36	NALTRE*THERAPY*month	1	0	2	
Prm37	NALTRE*THERAPY*month	1	0	1	
Prm38	NALTRE*THERAPY*month	0	1	4	
Prm39	NALTRE*THERAPY*month	0	1	3	
Prm40	NALTRE*THERAPY*month	0	1	2	
Prm41	NALTRE*THERAPY*month	0	1	1	
Prm42	NALTRE*THERAPY*month	0	0	4	
Prm43	NALTRE*THERAPY*month	0	0	3	
Prm44	NALTRE*THERAPY*month	0	0	2	
Prm45	NALTRE*THERAPY*month	0	0	1	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Unstructured	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Covariance Matrix (Model-Based)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.005390	-0.005390	-0.005390	0.005390	-0.001775	-0.001592	-0.001005	0.001775	0.001592	
Prm2	-0.005390	0.01091	0.005390	-0.01091	0.001775	0.001592	0.001005	-0.003593	-0.003228	
Prm4	-0.005390	0.005390	0.01081	-0.01081	0.001775	0.001592	0.001005	-0.001775	-0.001592	
Prm6	0.005390	-0.01091	-0.01081	0.02163	-0.001775	-0.001592	-0.001005	0.003593	0.003228	
Prm10	-0.001775	0.001775	0.001775	-0.001775	0.003613	0.002850	0.001613	-0.003613	-0.002850	
Prm11	-0.001592	0.001592	0.001592	-0.001592	0.002850	0.003216	0.001784	-0.002850	-0.003216	
Prm12	-0.001005	0.001005	0.001005	-0.001005	0.001613	0.001784	0.001995	-0.001613	-0.001784	
Prm14	0.001775	-0.003593	-0.001775	0.003593	-0.003613	-0.002850	-0.001613	0.007325	0.005782	
Prm15	0.001592	-0.003228	-0.001592	0.003228	-0.002850	-0.003216	-0.001784	0.005782	0.006525	
Prm16	0.001005	-0.002039	-0.001005	0.002039	-0.001613	-0.001784	-0.001995	0.003275	0.003622	
Prm22	0.001775	-0.001775	-0.003556	0.003556	-0.003613	-0.002850	-0.001613	0.003613	0.002850	
Prm23	0.001592	-0.001592	-0.003188	0.003188	-0.002850	-0.003216	-0.001784	0.002850	0.003216	
Prm24	0.001005	-0.001005	-0.002013	0.002013	-0.001613	-0.001784	-0.001995	0.001613	0.001784	
Prm30	-0.001775	0.003593	0.003556	-0.007093	0.003613	0.002850	0.001613	-0.007325	-0.005782	
Prm31	-0.001592	0.003228	0.003188	-0.006365	0.002850	0.003216	0.001784	-0.005782	-0.006525	
Prm32	-0.001005	0.002039	0.002013	-0.004025	0.001613	0.001784	0.001995	-0.003275	-0.003622	

Covariance Matrix (Model-Based)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.001005	0.001775	0.001592	0.001005	-0.001775	-0.001592	-0.001005	
Prm2	-0.002039	-0.001775	-0.001592	-0.001005	0.003593	0.003228	0.002039	
Prm4	-0.001005	-0.003556	-0.003188	-0.002013	0.003556	0.003188	0.002013	
Prm6	0.002039	0.003556	0.003188	0.002013	-0.007093	-0.006365	-0.004025	
Prm10	-0.001613	-0.003613	-0.002850	-0.001613	0.003613	0.002850	0.001613	
Prm11	-0.001784	-0.002850	-0.003216	-0.001784	0.002850	0.003216	0.001784	
Prm12	-0.001995	-0.001613	-0.001784	-0.001995	0.001613	0.001784	0.001995	
Prm14	0.003275	0.003613	0.002850	0.001613	-0.007325	-0.005782	-0.003275	
Prm15	0.003622	0.002850	0.003216	0.001784	-0.005782	-0.006525	-0.003622	
Prm16	0.004050	0.001613	0.001784	0.001995	-0.003275	-0.003622	-0.004050	
Prm22	0.001613	0.007256	0.005739	0.003255	-0.007256	-0.005739	-0.003255	
Prm23	0.001784	0.005739	0.006477	0.003603	-0.005739	-0.006477	-0.003603	
Prm24	0.001995	0.003255	0.003603	0.004030	-0.003255	-0.003603	-0.004030	
Prm30	-0.003275	-0.007256	-0.005739	-0.003255	0.01457	0.01152	0.006534	
Prm31	-0.003622	-0.005739	-0.006477	-0.003603	0.01152	0.01300	0.007231	
Prm32	-0.004050	-0.003255	-0.003603	-0.004030	0.006534	0.007231	0.008088	

Covariance Matrix (Empirical)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.004889	-0.004889	-0.004889	0.004889	-0.001799	-0.001434	-0.001072	0.001799	0.001434	
Prm2	-0.004889	0.01089	0.004889	-0.01089	0.001799	0.001434	0.001072	-0.003975	-0.003386	
Prm4	-0.004889	0.004889	0.01064	-0.01064	0.001799	0.001434	0.001072	-0.001799	-0.001434	
Prm6	0.004889	-0.01089	-0.01064	0.02190	-0.001799	-0.001434	-0.001072	0.003975	0.003386	
Prm10	-0.001799	0.001799	0.001799	-0.001799	0.002939	0.002186	0.001483	-0.002939	-0.002186	
Prm11	-0.001434	0.001434	0.001434	-0.001434	0.002186	0.002295	0.001462	-0.002186	-0.002295	
Prm12	-0.001072	0.001072	0.001072	-0.001072	0.001483	0.001462	0.001635	-0.001483	-0.001462	
Prm14	0.001799	-0.003975	-0.001799	0.003975	-0.002939	-0.002186	-0.001483	0.007843	0.006222	
Prm15	0.001434	-0.003386	-0.001434	0.003386	-0.002186	-0.002295	-0.001462	0.006222	0.006715	
Prm16	0.001072	-0.002420	-0.001072	0.002420	-0.001483	-0.001462	-0.001635	0.003937	0.004224	
Prm22	0.001799	-0.001799	-0.003919	0.003919	-0.002939	-0.002186	-0.001483	0.002939	0.002186	
Prm23	0.001434	-0.001434	-0.003429	0.003429	-0.002186	-0.002295	-0.001462	0.002186	0.002295	
Prm24	0.001072	-0.001072	-0.002284	0.002284	-0.001483	-0.001462	-0.001635	0.001483	0.001462	
Prm30	-0.001799	0.003975	0.003919	-0.007599	0.002939	0.002186	0.001483	-0.007843	-0.006222	
Prm31	-0.001434	0.003386	0.003429	-0.006854	0.002186	0.002295	0.001462	-0.006222	-0.006715	
Prm32	-0.001072	0.002420	0.002284	-0.004530	0.001483	0.001462	0.001635	-0.003937	-0.004224	

Covariance Matrix (Empirical)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.001072	0.001799	0.001434	0.001072	-0.001799	-0.001434	-0.001072	
Prm2	-0.002420	-0.001799	-0.001434	-0.001072	0.003975	0.003386	0.002420	
Prm4	-0.001072	-0.003919	-0.003429	-0.002284	0.003919	0.003429	0.002284	
Prm6	0.002420	0.003919	0.003429	0.002284	-0.007599	-0.006854	-0.004530	
Prm10	-0.001483	-0.002939	-0.002186	-0.001483	0.002939	0.002186	0.001483	
Prm11	-0.001462	-0.002186	-0.002295	-0.001462	0.002186	0.002295	0.001462	
Prm12	-0.001635	-0.001483	-0.001462	-0.001635	0.001483	0.001462	0.001635	
Prm14	0.003937	0.002939	0.002186	0.001483	-0.007843	-0.006222	-0.003937	
Prm15	0.004224	0.002186	0.002295	0.001462	-0.006222	-0.006715	-0.004224	
Prm16	0.004482	0.001483	0.001462	0.001635	-0.003937	-0.004224	-0.004482	
Prm22	0.001483	0.007128	0.005422	0.003386	-0.007128	-0.005422	-0.003386	
Prm23	0.001462	0.005422	0.006015	0.003407	-0.005422	-0.006015	-0.003407	
Prm24	0.001635	0.003386	0.003407	0.003569	-0.003386	-0.003407	-0.003569	
Prm30	-0.003937	-0.007128	-0.005422	-0.003386	0.01574	0.01203	0.007099	
Prm31	-0.004224	-0.005422	-0.006015	-0.003407	0.01203	0.01371	0.007765	
Prm32	-0.004482	-0.003386	-0.003407	-0.003569	0.007099	0.007765	0.008074	

Algorithm converged.	

Working Correlation Matrix	
	Col1	Col2	Col3	Col4	
Row1	1.0000	0.8173	0.7082	0.6745	
Row2	0.8173	1.0000	0.8521	0.7870	
Row3	0.7082	0.8521	1.0000	0.9003	
Row4	0.6745	0.7870	0.9003	1.0000	

GEE Fit Criteria	
QIC	-154124.0076	
QICu	-154123.3190	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4653	0.0699	-1.6023	-1.3282	-20.96	<.0001	
NALTREXONE	1			-0.2282	0.1044	-0.4328	-0.0236	-2.19	0.0288	
NALTREXONE	0			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	1			-0.1255	0.1031	-0.3277	0.0766	-1.22	0.2236	
THERAPY	0			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.3624	0.1480	0.0723	0.6524	2.45	0.0143	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.0000	0.0000	0.0000	0.0000	.	.	
month	4			0.3027	0.0542	0.1965	0.4090	5.58	<.0001	
month	3			0.2640	0.0479	0.1701	0.3579	5.51	<.0001	
month	2			0.2096	0.0404	0.1304	0.2889	5.18	<.0001	
month	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		-0.0646	0.0886	-0.2381	0.1090	-0.73	0.4659	
NALTREXONE*month	1	3		-0.0410	0.0819	-0.2016	0.1197	-0.50	0.6172	
NALTREXONE*month	1	2		-0.0045	0.0669	-0.1357	0.1267	-0.07	0.9467	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		-0.1256	0.0844	-0.2911	0.0399	-1.49	0.1368	
THERAPY*month	1	3		-0.1178	0.0776	-0.2698	0.0342	-1.52	0.1289	
THERAPY*month	1	2		-0.0565	0.0597	-0.1736	0.0606	-0.95	0.3446	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	-0.1087	0.1255	-0.3546	0.1372	-0.87	0.3864	
NALTRE*THERAPY*month	1	1	3	-0.0840	0.1171	-0.3135	0.1455	-0.72	0.4732	
NALTRE*THERAPY*month	1	1	2	-0.0778	0.0899	-0.2539	0.0983	-0.87	0.3865	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.59	0.1074	
THERAPY	1	0.62	0.4305	
NALTREXONE*THERAPY	1	4.78	0.0288	
month	3	50.05	<.0001	
NALTREXONE*month	3	3.66	0.3009	
THERAPY*month	3	8.45	0.0375	
NALTRE*THERAPY*month	3	0.96	0.8108	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.4326	0.06738	-21.26	<.0001	0.05	-1.5647	-1.3006	0.2387	0.01608	
1	0	-1.5269	0.07200	-21.21	<.0001	0.05	-1.6680	-1.3858	0.2172	0.01564	
0	1	-1.4717	0.06772	-21.73	<.0001	0.05	-1.6044	-1.3390	0.2295	0.01554	
0	0	-1.2712	0.06170	-20.60	<.0001	0.05	-1.3921	-1.1503	0.2805	0.01731	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.2092	0.2724	0.2387	0.2092	0.2724	
1	0	0.1886	0.2501	0.2172	0.1886	0.2501	
0	1	0.2010	0.2621	0.2295	0.2010	0.2621	
0	0	0.2485	0.3166	0.2805	0.2485	0.3166	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.09428	0.09861	0.96	0.3391	0.05	
1	1	0	1	0.03906	0.09553	0.41	0.6827	0.05	
1	1	0	0	-0.1614	0.09136	-1.77	0.0772	0.05	
1	0	0	1	-0.05522	0.09884	-0.56	0.5764	0.05	
1	0	0	0	-0.2557	0.09482	-2.70	0.0070	0.05	
0	1	0	0	-0.2005	0.09161	-2.19	0.0286	0.05	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.09900	0.2876	1.0989	
1	1	0	1	-0.1482	0.2263	1.0398	
1	1	0	0	-0.3405	0.01764	0.8509	
1	0	0	1	-0.2489	0.1385	0.9463	
1	0	0	0	-0.4416	-0.06987	0.7744	
0	1	0	0	-0.3800	-0.02093	0.8183	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.9057	1.3332	
1	1	0	1	0.8623	1.2539	
1	1	0	0	0.7114	1.0178	
1	0	0	1	0.7796	1.1486	
1	0	0	0	0.6430	0.9325	
0	1	0	0	0.6838	0.9793	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.4326	0.06738	-21.26	<.0001	0.0083	-1.6104	-1.2548	0.2387	0.01608	
1	0	-1.5269	0.07200	-21.21	<.0001	0.0083	-1.7169	-1.3369	0.2172	0.01564	
0	1	-1.4717	0.06772	-21.73	<.0001	0.0083	-1.6503	-1.2930	0.2295	0.01554	
0	0	-1.2712	0.06170	-20.60	<.0001	0.0083	-1.4340	-1.1084	0.2805	0.01731	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.1998	0.2851	0.2387	0.1998	0.2851	
1	0	0.1796	0.2626	0.2172	0.1796	0.2626	
0	1	0.1920	0.2744	0.2295	0.1920	0.2744	
0	0	0.2384	0.3301	0.2805	0.2384	0.3301	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.09428	0.09861	0.96	0.3391	0.0083	
1	1	0	1	0.03906	0.09553	0.41	0.6827	0.0083	
1	1	0	0	-0.1614	0.09136	-1.77	0.0772	0.0083	
1	0	0	1	-0.05522	0.09884	-0.56	0.5764	0.0083	
1	0	0	0	-0.2557	0.09482	-2.70	0.0070	0.0083	
0	1	0	0	-0.2005	0.09161	-2.19	0.0286	0.0083	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.1659	0.3545	1.0989	
1	1	0	1	-0.2130	0.2911	1.0398	
1	1	0	0	-0.4025	0.07962	0.8509	
1	0	0	1	-0.3160	0.2056	0.9463	
1	0	0	0	-0.5059	-0.00554	0.7744	
0	1	0	0	-0.4422	0.04122	0.8183	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.8471	1.4254	
1	1	0	1	0.8082	1.3379	
1	1	0	0	0.6687	1.0829	
1	0	0	1	0.7291	1.2282	
1	0	0	0	0.6030	0.9945	
0	1	0	0	0.6426	1.0421	

THERAPY*month Least Squares Means	
THERAPY	month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	Lower Mean	Upper Mean	
1	4	-1.4332	0.05399	-26.55	<.0001	0.05	-1.5390	-1.3274	0.2385	0.01288	0.2146	0.2652	
1	3	-1.4400	0.05261	-27.37	<.0001	0.05	-1.5431	-1.3368	0.2369	0.01247	0.2137	0.2627	
1	2	-1.4117	0.05094	-27.71	<.0001	0.05	-1.5115	-1.3119	0.2437	0.01242	0.2206	0.2693	
1	1	-1.5237	0.05246	-29.05	<.0001	0.05	-1.6265	-1.4209	0.2179	0.01143	0.1966	0.2415	
0	4	-1.3089	0.05193	-25.21	<.0001	0.05	-1.4107	-1.2072	0.2701	0.01403	0.2440	0.2990	
0	3	-1.3359	0.05205	-25.66	<.0001	0.05	-1.4379	-1.2338	0.2629	0.01369	0.2374	0.2912	
0	2	-1.3720	0.05132	-26.73	<.0001	0.05	-1.4726	-1.2714	0.2536	0.01302	0.2293	0.2804	
0	1	-1.5794	0.05219	-30.26	<.0001	0.05	-1.6817	-1.4771	0.2061	0.01076	0.1861	0.2283	

THERAPY*month Least Squares Means	
THERAPY	month	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	4	0.2385	0.2146	0.2652	
1	3	0.2369	0.2137	0.2627	
1	2	0.2437	0.2206	0.2693	
1	1	0.2179	0.1966	0.2415	
0	4	0.2701	0.2440	0.2990	
0	3	0.2629	0.2374	0.2912	
0	2	0.2536	0.2293	0.2804	
0	1	0.2061	0.1861	0.2283	

Differences of THERAPY*month Least Squares Means	
THERAPY	month	_THERAPY	_month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	
1	4	1	3	0.006751	0.02864	0.24	0.8136	0.05	-0.04938	0.06288	
1	4	1	2	-0.02150	0.03594	-0.60	0.5497	0.05	-0.09194	0.04894	
1	4	1	1	0.09050	0.04444	2.04	0.0417	0.05	0.003408	0.1776	
1	4	0	4	-0.1243	0.07490	-1.66	0.0971	0.05	-0.2711	0.02253	
1	4	0	3	-0.09735	0.07499	-1.30	0.1942	0.05	-0.2443	0.04963	
1	4	0	2	-0.06121	0.07449	-0.82	0.4112	0.05	-0.2072	0.08478	
1	4	0	1	0.1462	0.07508	1.95	0.0516	0.05	-0.00100	0.2933	
1	3	1	2	-0.02825	0.02962	-0.95	0.3402	0.05	-0.08631	0.02980	
1	3	1	1	0.08375	0.04183	2.00	0.0453	0.05	0.001762	0.1657	
1	3	0	4	-0.1310	0.07392	-1.77	0.0763	0.05	-0.2759	0.01385	
1	3	0	3	-0.1041	0.07401	-1.41	0.1595	0.05	-0.2492	0.04095	
1	3	0	2	-0.06796	0.07350	-0.92	0.3551	0.05	-0.2120	0.07609	
1	3	0	1	0.1394	0.07410	1.88	0.0599	0.05	-0.00583	0.2846	
1	2	1	1	0.1120	0.02997	3.74	0.0002	0.05	0.05327	0.1707	
1	2	0	4	-0.1028	0.07274	-1.41	0.1577	0.05	-0.2453	0.03979	
1	2	0	3	-0.07585	0.07283	-1.04	0.2977	0.05	-0.2186	0.06690	
1	2	0	2	-0.03971	0.07231	-0.55	0.5829	0.05	-0.1814	0.1020	
1	2	0	1	0.1677	0.07293	2.30	0.0215	0.05	0.02473	0.3106	
1	1	0	4	-0.2148	0.07381	-2.91	0.0036	0.05	-0.3595	-0.07011	
1	1	0	3	-0.1878	0.07390	-2.54	0.0110	0.05	-0.3327	-0.04301	
1	1	0	2	-0.1517	0.07339	-2.07	0.0387	0.05	-0.2955	-0.00787	
1	1	0	1	0.05566	0.07400	0.75	0.4519	0.05	-0.08937	0.2007	
0	4	0	3	0.02693	0.02299	1.17	0.2413	0.05	-0.01812	0.07199	
0	4	0	2	0.06307	0.03336	1.89	0.0586	0.05	-0.00230	0.1284	
0	4	0	1	0.2704	0.04428	6.11	<.0001	0.05	0.1837	0.3572	
0	3	0	2	0.03614	0.02622	1.38	0.1680	0.05	-0.01524	0.08752	
0	3	0	1	0.2435	0.04097	5.94	<.0001	0.05	0.1632	0.3238	
0	2	0	1	0.2074	0.03347	6.20	<.0001	0.05	0.1418	0.2730	

Differences of THERAPY*month Least Squares Means	
THERAPY	month	_THERAPY	_month	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	4	1	3	1.0068	0.9518	1.0649	
1	4	1	2	0.9787	0.9122	1.0502	
1	4	1	1	1.0947	1.0034	1.1943	
1	4	0	4	0.8831	0.7625	1.0228	
1	4	0	3	0.9072	0.7832	1.0509	
1	4	0	2	0.9406	0.8129	1.0885	
1	4	0	1	1.1574	0.9990	1.3409	
1	3	1	2	0.9721	0.9173	1.0303	
1	3	1	1	1.0874	1.0018	1.1803	
1	3	0	4	0.8772	0.7589	1.0139	
1	3	0	3	0.9011	0.7795	1.0418	
1	3	0	2	0.9343	0.8090	1.0791	
1	3	0	1	1.1496	0.9942	1.3293	
1	2	1	1	1.1185	1.0547	1.1862	
1	2	0	4	0.9023	0.7824	1.0406	
1	2	0	3	0.9270	0.8036	1.0692	
1	2	0	2	0.9611	0.8341	1.1074	
1	2	0	1	1.1825	1.0250	1.3642	
1	1	0	4	0.8067	0.6981	0.9323	
1	1	0	3	0.8287	0.7170	0.9579	
1	1	0	2	0.8592	0.7441	0.9922	
1	1	0	1	1.0572	0.9145	1.2222	
0	4	0	3	1.0273	0.9820	1.0746	
0	4	0	2	1.0651	0.9977	1.1371	
0	4	0	1	1.3105	1.2016	1.4294	
0	3	0	2	1.0368	0.9849	1.0915	
0	3	0	1	1.2757	1.1773	1.3824	
0	2	0	1	1.2304	1.1523	1.3139	

THERAPY*month Least Squares Means	
THERAPY	month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	Lower Mean	Upper Mean	
1	4	-1.4332	0.05399	-26.55	<.0001	0.0125	-1.5680	-1.2984	0.2385	0.01288	0.2085	0.2730	
1	3	-1.4400	0.05261	-27.37	<.0001	0.0125	-1.5714	-1.3086	0.2369	0.01247	0.2078	0.2702	
1	2	-1.4117	0.05094	-27.71	<.0001	0.0125	-1.5389	-1.2845	0.2437	0.01242	0.2146	0.2768	
1	1	-1.5237	0.05246	-29.05	<.0001	0.0125	-1.6547	-1.3927	0.2179	0.01143	0.1911	0.2484	
0	4	-1.3089	0.05193	-25.21	<.0001	0.0125	-1.4386	-1.1792	0.2701	0.01403	0.2373	0.3075	
0	3	-1.3359	0.05205	-25.66	<.0001	0.0125	-1.4659	-1.2059	0.2629	0.01369	0.2309	0.2994	
0	2	-1.3720	0.05132	-26.73	<.0001	0.0125	-1.5002	-1.2438	0.2536	0.01302	0.2231	0.2883	
0	1	-1.5794	0.05219	-30.26	<.0001	0.0125	-1.7097	-1.4490	0.2061	0.01076	0.1809	0.2348	

THERAPY*month Least Squares Means	
THERAPY	month	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	4	0.2385	0.2085	0.2730	
1	3	0.2369	0.2078	0.2702	
1	2	0.2437	0.2146	0.2768	
1	1	0.2179	0.1911	0.2484	
0	4	0.2701	0.2373	0.3075	
0	3	0.2629	0.2309	0.2994	
0	2	0.2536	0.2231	0.2883	
0	1	0.2061	0.1809	0.2348	

Differences of THERAPY*month Least Squares Means	
THERAPY	month	_THERAPY	_month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	
1	4	1	3	0.006751	0.02864	0.24	0.8136	0.0125	-0.06478	0.07828	
1	4	1	2	-0.02150	0.03594	-0.60	0.5497	0.0125	-0.1113	0.06826	
1	4	1	1	0.09050	0.04444	2.04	0.0417	0.0125	-0.02049	0.2015	
1	4	0	4	-0.1243	0.07490	-1.66	0.0971	0.0125	-0.3114	0.06281	
1	4	0	3	-0.09735	0.07499	-1.30	0.1942	0.0125	-0.2847	0.08996	
1	4	0	2	-0.06121	0.07449	-0.82	0.4112	0.0125	-0.2473	0.1248	
1	4	0	1	0.1462	0.07508	1.95	0.0516	0.0125	-0.04138	0.3337	
1	3	1	2	-0.02825	0.02962	-0.95	0.3402	0.0125	-0.1022	0.04573	
1	3	1	1	0.08375	0.04183	2.00	0.0453	0.0125	-0.02073	0.1882	
1	3	0	4	-0.1310	0.07392	-1.77	0.0763	0.0125	-0.3157	0.05360	
1	3	0	3	-0.1041	0.07401	-1.41	0.1595	0.0125	-0.2889	0.08075	
1	3	0	2	-0.06796	0.07350	-0.92	0.3551	0.0125	-0.2515	0.1156	
1	3	0	1	0.1394	0.07410	1.88	0.0599	0.0125	-0.04567	0.3245	
1	2	1	1	0.1120	0.02997	3.74	0.0002	0.0125	0.03715	0.1868	
1	2	0	4	-0.1028	0.07274	-1.41	0.1577	0.0125	-0.2845	0.07890	
1	2	0	3	-0.07585	0.07283	-1.04	0.2977	0.0125	-0.2578	0.1061	
1	2	0	2	-0.03971	0.07231	-0.55	0.5829	0.0125	-0.2203	0.1409	
1	2	0	1	0.1677	0.07293	2.30	0.0215	0.0125	-0.01449	0.3498	
1	1	0	4	-0.2148	0.07381	-2.91	0.0036	0.0125	-0.3991	-0.03042	
1	1	0	3	-0.1878	0.07390	-2.54	0.0110	0.0125	-0.3724	-0.00327	
1	1	0	2	-0.1517	0.07339	-2.07	0.0387	0.0125	-0.3350	0.03159	
1	1	0	1	0.05566	0.07400	0.75	0.4519	0.0125	-0.1292	0.2405	
0	4	0	3	0.02693	0.02299	1.17	0.2413	0.0125	-0.03048	0.08435	
0	4	0	2	0.06307	0.03336	1.89	0.0586	0.0125	-0.02024	0.1464	
0	4	0	1	0.2704	0.04428	6.11	<.0001	0.0125	0.1598	0.3810	
0	3	0	2	0.03614	0.02622	1.38	0.1680	0.0125	-0.02934	0.1016	
0	3	0	1	0.2435	0.04097	5.94	<.0001	0.0125	0.1412	0.3458	
0	2	0	1	0.2074	0.03347	6.20	<.0001	0.0125	0.1238	0.2910	

Differences of THERAPY*month Least Squares Means	
THERAPY	month	_THERAPY	_month	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	4	1	3	1.0068	0.9373	1.0814	
1	4	1	2	0.9787	0.8947	1.0706	
1	4	1	1	1.0947	0.9797	1.2232	
1	4	0	4	0.8831	0.7324	1.0648	
1	4	0	3	0.9072	0.7523	1.0941	
1	4	0	2	0.9406	0.7809	1.1330	
1	4	0	1	1.1574	0.9595	1.3961	
1	3	1	2	0.9721	0.9028	1.0468	
1	3	1	1	1.0874	0.9795	1.2071	
1	3	0	4	0.8772	0.7293	1.0551	
1	3	0	3	0.9011	0.7491	1.0841	
1	3	0	2	0.9343	0.7776	1.1226	
1	3	0	1	1.1496	0.9554	1.3833	
1	2	1	1	1.1185	1.0379	1.2054	
1	2	0	4	0.9023	0.7524	1.0821	
1	2	0	3	0.9270	0.7728	1.1119	
1	2	0	2	0.9611	0.8023	1.1513	
1	2	0	1	1.1825	0.9856	1.4188	
1	1	0	4	0.8067	0.6709	0.9700	
1	1	0	3	0.8287	0.6891	0.9967	
1	1	0	2	0.8592	0.7153	1.0321	
1	1	0	1	1.0572	0.8788	1.2719	
0	4	0	3	1.0273	0.9700	1.0880	
0	4	0	2	1.0651	0.9800	1.1576	
0	4	0	1	1.3105	1.1733	1.4638	
0	3	0	2	1.0368	0.9711	1.1070	
0	3	0	1	1.2757	1.1516	1.4132	
0	2	0	1	1.2304	1.1317	1.3377	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Unstructured	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Covariance Matrix (Model-Based)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.005464	-0.005464	-0.005464	0.005464	-0.001883	-0.001246	-0.000577	0.001883	0.001246	
Prm2	-0.005464	0.01097	0.005464	-0.01097	0.001883	0.001246	0.0005770	-0.003746	-0.002474	
Prm4	-0.005464	0.005464	0.01106	-0.01106	0.001883	0.001246	0.0005770	-0.001883	-0.001246	
Prm6	0.005464	-0.01097	-0.01106	0.02202	-0.001883	-0.001246	-0.000577	0.003746	0.002474	
Prm10	-0.001883	0.001883	0.001883	-0.001883	0.003603	0.001987	0.0007548	-0.003603	-0.001987	
Prm11	-0.001246	0.001246	0.001246	-0.001246	0.001987	0.002373	0.0009286	-0.001987	-0.002373	
Prm12	-0.000577	0.0005770	0.0005770	-0.000577	0.0007548	0.0009286	0.001124	-0.000755	-0.000929	
Prm14	0.001883	-0.003746	-0.001883	0.003746	-0.003603	-0.001987	-0.000755	0.007246	0.003987	
Prm15	0.001246	-0.002474	-0.001246	0.002474	-0.001987	-0.002373	-0.000929	0.003987	0.004766	
Prm16	0.0005770	-0.001147	-0.000577	0.001147	-0.000755	-0.000929	-0.001124	0.001509	0.001859	
Prm22	0.001883	-0.001883	-0.003777	0.003777	-0.003603	-0.001987	-0.000755	0.003603	0.001987	
Prm23	0.001246	-0.001246	-0.002511	0.002511	-0.001987	-0.002373	-0.000929	0.001987	0.002373	
Prm24	0.0005770	-0.000577	-0.001175	0.001175	-0.000755	-0.000929	-0.001124	0.0007548	0.0009286	
Prm30	-0.001883	0.003746	0.003777	-0.007477	0.003603	0.001987	0.0007548	-0.007246	-0.003987	
Prm31	-0.001246	0.002474	0.002511	-0.004969	0.001987	0.002373	0.0009286	-0.003987	-0.004766	
Prm32	-0.000577	0.001147	0.001175	-0.002324	0.0007548	0.0009286	0.001124	-0.001509	-0.001859	

Covariance Matrix (Model-Based)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.0005770	0.001883	0.001246	0.0005770	-0.001883	-0.001246	-0.000577	
Prm2	-0.001147	-0.001883	-0.001246	-0.000577	0.003746	0.002474	0.001147	
Prm4	-0.000577	-0.003777	-0.002511	-0.001175	0.003777	0.002511	0.001175	
Prm6	0.001147	0.003777	0.002511	0.001175	-0.007477	-0.004969	-0.002324	
Prm10	-0.000755	-0.003603	-0.001987	-0.000755	0.003603	0.001987	0.0007548	
Prm11	-0.000929	-0.001987	-0.002373	-0.000929	0.001987	0.002373	0.0009286	
Prm12	-0.001124	-0.000755	-0.000929	-0.001124	0.0007548	0.0009286	0.001124	
Prm14	0.001509	0.003603	0.001987	0.0007548	-0.007246	-0.003987	-0.001509	
Prm15	0.001859	0.001987	0.002373	0.0009286	-0.003987	-0.004766	-0.001859	
Prm16	0.002251	0.0007548	0.0009286	0.001124	-0.001509	-0.001859	-0.002251	
Prm22	0.0007548	0.007315	0.004036	0.001535	-0.007315	-0.004036	-0.001535	
Prm23	0.0009286	0.004036	0.004816	0.001884	-0.004036	-0.004816	-0.001884	
Prm24	0.001124	0.001535	0.001884	0.002280	-0.001535	-0.001884	-0.002280	
Prm30	-0.001509	-0.007315	-0.004036	-0.001535	0.01457	0.008036	0.003052	
Prm31	-0.001859	-0.004036	-0.004816	-0.001884	0.008036	0.009591	0.003749	
Prm32	-0.002251	-0.001535	-0.001884	-0.002280	0.003052	0.003749	0.004535	

Covariance Matrix (Empirical)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.005960	-0.005960	-0.005960	0.005960	-0.002205	-0.001844	-0.001106	0.002205	0.001844	
Prm2	-0.005960	0.01166	0.005960	-0.01166	0.002205	0.001844	0.001106	-0.004274	-0.003222	
Prm4	-0.005960	0.005960	0.01252	-0.01252	0.002205	0.001844	0.001106	-0.002205	-0.001844	
Prm6	0.005960	-0.01166	-0.01252	0.02244	-0.002205	-0.001844	-0.001106	0.004274	0.003222	
Prm10	-0.002205	0.002205	0.002205	-0.002205	0.003709	0.002450	0.001137	-0.003709	-0.002450	
Prm11	-0.001844	0.001844	0.001844	-0.001844	0.002450	0.002849	0.001473	-0.002450	-0.002849	
Prm12	-0.001106	0.001106	0.001106	-0.001106	0.001137	0.001473	0.001843	-0.001137	-0.001473	
Prm14	0.002205	-0.004274	-0.002205	0.004274	-0.003709	-0.002450	-0.001137	0.007898	0.004736	
Prm15	0.001844	-0.003222	-0.001844	0.003222	-0.002450	-0.002849	-0.001473	0.004736	0.005166	
Prm16	0.001106	-0.001934	-0.001106	0.001934	-0.001137	-0.001473	-0.001843	0.002090	0.002469	
Prm22	0.002205	-0.002205	-0.004933	0.004933	-0.003709	-0.002450	-0.001137	0.003709	0.002450	
Prm23	0.001844	-0.001844	-0.003465	0.003465	-0.002450	-0.002849	-0.001473	0.002450	0.002849	
Prm24	0.001106	-0.001106	-0.001749	0.001749	-0.001137	-0.001473	-0.001843	0.001137	0.001473	
Prm30	-0.002205	0.004274	0.004933	-0.008141	0.003709	0.002450	0.001137	-0.007898	-0.004736	
Prm31	-0.001844	0.003222	0.003465	-0.005572	0.002450	0.002849	0.001473	-0.004736	-0.005166	
Prm32	-0.001106	0.001934	0.001749	-0.002964	0.001137	0.001473	0.001843	-0.002090	-0.002469	

Covariance Matrix (Empirical)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.001106	0.002205	0.001844	0.001106	-0.002205	-0.001844	-0.001106	
Prm2	-0.001934	-0.002205	-0.001844	-0.001106	0.004274	0.003222	0.001934	
Prm4	-0.001106	-0.004933	-0.003465	-0.001749	0.004933	0.003465	0.001749	
Prm6	0.001934	0.004933	0.003465	0.001749	-0.008141	-0.005572	-0.002964	
Prm10	-0.001137	-0.003709	-0.002450	-0.001137	0.003709	0.002450	0.001137	
Prm11	-0.001473	-0.002450	-0.002849	-0.001473	0.002450	0.002849	0.001473	
Prm12	-0.001843	-0.001137	-0.001473	-0.001843	0.001137	0.001473	0.001843	
Prm14	0.002090	0.003709	0.002450	0.001137	-0.007898	-0.004736	-0.002090	
Prm15	0.002469	0.002450	0.002849	0.001473	-0.004736	-0.005166	-0.002469	
Prm16	0.003281	0.001137	0.001473	0.001843	-0.002090	-0.002469	-0.003281	
Prm22	0.001137	0.008613	0.004900	0.002004	-0.008613	-0.004900	-0.002004	
Prm23	0.001473	0.004900	0.005691	0.002649	-0.004900	-0.005691	-0.002649	
Prm24	0.001843	0.002004	0.002649	0.003096	-0.002004	-0.002649	-0.003096	
Prm30	-0.002090	-0.008613	-0.004900	-0.002004	0.01574	0.008642	0.003710	
Prm31	-0.002469	-0.004900	-0.005691	-0.002649	0.008642	0.009617	0.004376	
Prm32	-0.003281	-0.002004	-0.002649	-0.003096	0.003710	0.004376	0.005394	

Algorithm converged.	

Working Correlation Matrix	
	Col1	Col2	Col3	Col4	
Row1	1.0000	0.8173	0.7082	0.6745	
Row2	0.8173	1.0000	0.8521	0.7870	
Row3	0.7082	0.8521	1.0000	0.9003	
Row4	0.6745	0.7870	0.9003	1.0000	

GEE Fit Criteria	
QIC	-154124.0076	
QICu	-154123.3190	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4527	0.0772	-1.6041	-1.3014	-18.82	<.0001	
NALTREXONE	0			0.0391	0.1080	-0.1726	0.2507	0.36	0.7175	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			-0.0026	0.1119	-0.2218	0.2167	-0.02	0.9816	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2537	0.1498	-0.0399	0.5473	1.69	0.0903	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0039	0.0609	-0.1232	0.1155	-0.06	0.9492	
month	2			0.0670	0.0534	-0.0376	0.1716	1.25	0.2095	
month	3			0.0174	0.0429	-0.0668	0.1015	0.41	0.6854	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1732	0.0889	-0.3474	0.0009	-1.95	0.0513	
NALTREXONE*month	0	2		-0.0910	0.0719	-0.2318	0.0499	-1.27	0.2057	
NALTREXONE*month	0	3		-0.0483	0.0573	-0.1606	0.0640	-0.84	0.3991	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2343	0.0928	-0.4162	-0.0524	-2.52	0.0116	
THERAPY*month	0	2		-0.1000	0.0754	-0.2479	0.0479	-1.33	0.1850	
THERAPY*month	0	3		-0.0325	0.0556	-0.1416	0.0765	-0.58	0.5589	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1087	0.1255	-0.1372	0.3546	0.87	0.3864	
NALTRE*THERAPY*month	0	0	2	0.0309	0.0981	-0.1613	0.2231	0.31	0.7530	
NALTRE*THERAPY*month	0	0	3	0.0247	0.0734	-0.1193	0.1686	0.34	0.7370	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.59	0.1074	
THERAPY	1	0.62	0.4305	
NALTREXONE*THERAPY	1	4.78	0.0288	
month	3	50.05	<.0001	
NALTREXONE*month	3	3.66	0.3009	
THERAPY*month	3	8.45	0.0375	
NALTRE*THERAPY*month	3	0.96	0.8108	

month Least Squares Means	
month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	Lower Mean	Upper Mean	Exponentiated	
1	-1.5515	0.03700	-41.94	<.0001	0.05	-1.6241	-1.4790	0.2119	0.007841	0.1971	0.2279	0.2119	
2	-1.3919	0.03616	-38.50	<.0001	0.05	-1.4627	-1.3210	0.2486	0.008989	0.2316	0.2669	0.2486	
3	-1.3879	0.03700	-37.51	<.0001	0.05	-1.4604	-1.3154	0.2496	0.009236	0.2321	0.2684	0.2496	
4	-1.3711	0.03745	-36.61	<.0001	0.05	-1.4445	-1.2977	0.2538	0.009507	0.2359	0.2732	0.2538	

month Least Squares Means	
month	Exponentiated Lower	Exponentiated Upper	
1	0.1971	0.2279	
2	0.2316	0.2669	
3	0.2321	0.2684	
4	0.2359	0.2732	

Differences of month Least Squares Means	
month	_month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Exponentiated	
1	2	-0.1597	0.02246	-7.11	<.0001	0.05	-0.2037	-0.1157	0.8524	
1	3	-0.1636	0.02928	-5.59	<.0001	0.05	-0.2210	-0.1062	0.8491	
1	4	-0.1805	0.03137	-5.75	<.0001	0.05	-0.2419	-0.1190	0.8349	
2	3	-0.00394	0.01978	-0.20	0.8419	0.05	-0.04271	0.03482	0.9961	
2	4	-0.02079	0.02452	-0.85	0.3965	0.05	-0.06884	0.02727	0.9794	
3	4	-0.01684	0.01836	-0.92	0.3590	0.05	-0.05283	0.01915	0.9833	

Differences of month Least Squares Means	
month	_month	Exponentiated Lower	Exponentiated Upper	
1	2	0.8157	0.8908	
1	3	0.8017	0.8992	
1	4	0.7851	0.8878	
2	3	0.9582	1.0354	
2	4	0.9335	1.0276	
3	4	0.9485	1.0193	

month Least Squares Means	
month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	Lower Mean	Upper Mean	Exponentiated	
1	-1.5515	0.03700	-41.94	<.0001	0.0083	-1.6492	-1.4539	0.2119	0.007841	0.1922	0.2337	0.2119	
2	-1.3919	0.03616	-38.50	<.0001	0.0083	-1.4872	-1.2965	0.2486	0.008989	0.2260	0.2735	0.2486	
3	-1.3879	0.03700	-37.51	<.0001	0.0083	-1.4855	-1.2903	0.2496	0.009236	0.2264	0.2752	0.2496	
4	-1.3711	0.03745	-36.61	<.0001	0.0083	-1.4699	-1.2723	0.2538	0.009507	0.2300	0.2802	0.2538	

month Least Squares Means	
month	Exponentiated Lower	Exponentiated Upper	
1	0.1922	0.2337	
2	0.2260	0.2735	
3	0.2264	0.2752	
4	0.2300	0.2802	

Differences of month Least Squares Means	
month	_month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Exponentiated	
1	2	-0.1597	0.02246	-7.11	<.0001	0.0083	-0.2190	-0.1004	0.8524	
1	3	-0.1636	0.02928	-5.59	<.0001	0.0083	-0.2409	-0.08638	0.8491	
1	4	-0.1805	0.03137	-5.75	<.0001	0.0083	-0.2632	-0.09772	0.8349	
2	3	-0.00394	0.01978	-0.20	0.8419	0.0083	-0.05613	0.04824	0.9961	
2	4	-0.02079	0.02452	-0.85	0.3965	0.0083	-0.08547	0.04390	0.9794	
3	4	-0.01684	0.01836	-0.92	0.3590	0.0083	-0.06529	0.03160	0.9833	

Differences of month Least Squares Means	
month	_month	Exponentiated Lower	Exponentiated Upper	
1	2	0.8034	0.9045	
1	3	0.7859	0.9172	
1	4	0.7686	0.9069	
2	3	0.9454	1.0494	
2	4	0.9181	1.0449	
3	4	0.9368	1.0321