{"text_format":"2","workbook":"xlsx","n_sheets":4,"sheets":["hcASD","pASD","Burden_LoF","56_families"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":3,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"hcASD","index":0,"n_rows":23,"n_cols":14,"rows_kept":23,"cut":false,"hidden":false,"merged":[]}
["category","gene_count","sample","chr","pos_hg19","ref","var","gene","effect","source","variant confirmed","confirming group","expression data from Kang, 2011","probe set in Kang et al., 2011"]
["hcASD",3,"12752.p1","chr14",21861376,"ACT","A","CHD8","Frameshift","O'Roak,2012a","yes","Eichler","yes","extended"]
["hcASD",3,"13844.p1","chr14",21871178,"G","A","CHD8","Nonsense","O'Roak,2012a","yes","Eichler","yes","extended"]
["hcASD",3,"11654.p1","chr14",21871373,"T","C","CHD8","SpliceSite","O'Roak,2012b","yes","Eichler","yes","extended"]
["hcASD",3,"13890.p1","chr21",38865466,"G","A","DYRK1A","SpliceSite","O'Roak,2012a","yes","Eichler","yes","core"]
["hcASD",3,"12099.p1","chr21",38845116,"CAT","C","DYRK1A","Frameshift","O'Roak,2012b","yes","Eichler","yes","core"]
["hcASD",3,"13552.p1","chr21",38877834,"GC","G","DYRK1A","Frameshift","Iossifov,2012","yes","Wigler","yes","core"]
["hcASD",3,"12681.p1","chr12",13722953,"T","C","GRIN2B","SpliceSite","O'Roak,2012a","yes","Eichler","yes","core"]
["hcASD",3,"11691.p1","chr12",14019043,"T","TG","GRIN2B","Frameshift","O'Roak,2012a","yes","Eichler","yes","core"]
["hcASD",3,"12547.p1","chr12",13764762,"C","T","GRIN2B","Nonsense","O'Roak,2012a","yes","Eichler","yes","core"]
["hcASD",3,"5006_202","chr2",166164448,"G","A","SCN2A","SpliceSite","Neale,2012","yes","Neale","yes","core"]
["hcASD",3,"11114.p1","chr2",166210819,"G","T","SCN2A","Nonsense","Sanders,2012","yes","State","yes","core"]
["hcASD",3,"11892.p1","chr2",166201379,"C","A","SCN2A","Nonsense","Sanders,2012","yes","State","yes","core"]
["hcASD",2,"14256.p1","chr4",114251469,"C","T","ANK2","Nonsense","56_additional_families","yes","State","yes","core"]
["hcASD",2,"12645.p1","chr4",114232545,"C","T","ANK2","Nonsense","Iossifov,2012","yes","Wigler","yes","core"]
["hcASD",2,"11452.p1","chr2",225376218,"C","A","CUL3","Nonsense","O'Roak,2012a","yes","Eichler","yes","core"]
["hcASD",2,"Not_stated","chr2","Not_stated",".","p.R546X","CUL3","Nonsense","Kong,2012","?","NA","yes","core"]
["hcASD",2,"11872.p1","chr18",44603833,"G","C","KATNAL2","SpliceSite","O'Roak,2012a","yes","Eichler","yes","core"]
["hcASD",2,"11008.p1","chr18",44589733,"G","A","KATNAL2","SpliceSite","Sanders,2012","yes","State","yes","core"]
["hcASD",2,"10C102646","chr1",151379469,"G","GGTAC","POGZ","Frameshift","Neale,2012","yes","Neale","yes","core"]
["hcASD",2,"13398.p1","chr1",151377904,"C","CCGTCATCA","POGZ","Frameshift","Iossifov,2012","yes","Wigler","yes","core"]
["hcASD",2,"11480.p1","chr2",162273322,"AC","A","TBR1","Frameshift","O'Roak,2012a","yes","Eichler","yes","core"]
["hcASD",2,"13796.p1","chr2","Not_stated",".","p.S351X","TBR1","Frameshift","O'Roak,2012b","yes","Eichler","yes","core"]

{"sheet":"pASD","index":1,"n_rows":123,"n_cols":15,"rows_kept":123,"cut":false,"hidden":false,"merged":[]}
["category","gene_count","sample","chr","pos_hg19","ref","var","gene","effect","source","variant confirmed","confirming group","expression data from Kang, 2011","probe set in Kang et al., 2011","TADA p-value"]
["pASD",1,"13585.p1","chr12",109577550,"G","GG","ACACB","Frameshift","Iossifov,2012","yes","State","yes","core",7.1563612999999998E-2]
["pASD",1,"12561.p1","chr20",3655475,"G","A","ADAM33","Nonsense","Sanders,2012","yes","State","yes","core",1.17E-2]
["pASD",1,"12130.p1","chr20",49510027,"CTT","C","ADNP","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",6.0599999999999998E-4]
["pASD",1,"12792.p1","chr11",22276997,"C","T","ANO5","Nonsense","Iossifov,2012","yes","Wigler","yes","core",0.54900000000000004]
["pASD",1,"09C91621","chr1",150238957,"G","A","APH1A","Nonsense","Neale,2012","yes","Neale","yes","core",1.01E-3]
["pASD",1,"13447.p1","chr6",157527664,"CTGTT","C","ARID1B","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",3.7299999999999998E-3]
["pASD",1,"11715.p1","chr10",52005130,"T","TG","ASAH2","Frameshift","O'Roak,2012a","yes","Eichler","yes","core","NA"]
["pASD",1,"11282.p1","chr1",155317482,"C","CCTTG","ASH1L","Frameshift","Novel_indel","yes","State","yes","core",1.55E-2]
["pASD",1,"13616.p1","chr4",47571001,"G","GG","ATP10D","Frameshift","Iossifov,2012","yes","Wigler","yes","core",1.3899999999999999E-2]
["pASD",1,"12840.p1","chr1",169096506,"C","T","ATP1B1","Nonsense","Iossifov,2012","yes","Wigler","yes","core",6.96E-4]
["pASD",1,"13183.p1","chr2",60689254,"G","GG","BCL11A","Frameshift","Iossifov,2012","no","NA","yes","core",2.0300000000000001E-3]
["pASD",1,"13618.p1","chr8",37702145,"CAG","C","BRF2","Frameshift","Novel_indel","yes","State","yes","core",0.13400000000000001]
["pASD",1,"14292.p1","chr21",40568453,"GT","G","BRWD1","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",0.746]
["pASD",1,"11132.p1","chr6",26508728,"G","A","BTN1A1","SpliceSite","Sanders,2012","yes","State","yes","core",0.35399999999999998]
["pASD",1,"09C96618","chr20",42825855,"TGA","T","C20orf111","Frameshift","Neale,2012","yes","Neale","yes","core",0.40799999999999997]
["pASD",1,"13526.p1","chr3",54921984,"A","G","CACNA2D3","SpliceSite","Iossifov,2012","yes","Wigler","yes","core",1.137E-3]
["pASD",1,"12161.p1","chr13",111290774,"C","T","CARKD","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",0.27400000000000002]
["pASD",1,"13234.p1","chr17",77809050,"G","A","CBX4","Nonsense","Iossifov,2012","yes","Wigler","yes","core",1.15E-3]
["pASD",1,"13606.p1","chr14",103434646,"G","A","CDC42BPB","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",3.2100000000000002E-3]
["pASD",1,"12444.p1","chr19",54656675,"CTG","C","CNOT3","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",0.316]
["pASD",1,"12118.p1","chr4",109790273,"GT","G","COL25A1","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",1.63E-4]
["pASD",1,"13608.p1","chr1",115280664,"G","A","CSDE1","Nonsense","Sanders,2012","yes","State","yes","core",9.8500000000000004E-2]
["pASD",1,"13439.p1","chr10",53458250,"A","AA","CSTF2T","Frameshift","Iossifov,2012","yes","State","yes","core",3.0999999999999999E-3]
["pASD",1,"13070.p1","chr7",117423008,"TCA","T","CTTNBP2","Frameshift","Iossifov,2012","yes","Wigler","yes","core",0.1008]
["pASD",1,"13844.p1","chr10",17127755,"G","A","CUBN","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",0.32730340099999999]
["pASD",1,"11999.p1","chrX",41204655,"A","G","DDX3X","SpliceSite","Sanders,2012","yes","State","yes","core",3.8999999999999999E-4]
["pASD",1,"12015.p1","chr14",24513037,"G","A","DHRS4L1","Nonsense","O'Roak,2012a","yes","Eichler","no","NA",0.122]
["pASD",1,"13012.p1","chr21",47957426,"G","A","DIP2A","Nonsense","Iossifov,2012","yes","State","yes","core",2.8600000000000001E-3]
["pASD",1,"12705.p1","chr10",428609,"C","CC","DIP2C","Frameshift","Iossifov,2012","yes","Wigler","yes","core",4.8300000000000001E-3]
["pASD",1,"12653.p1","chr6",170593076,"A","AA","DLL1","Frameshift","Iossifov,2012","yes","State","yes","core",1.5200000000000001E-3]
["pASD",1,"11610.p1","chr5",13923403,"CA","C","DNAH5","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",0.60974053800000005]
["pASD",1,"13612.p1","chr6",56393644,"GGTTT","G","DST","Frameshift","Iossifov,2012","yes","Wigler","yes","core",0.499491252]
["pASD",1,"13364.p1","chr9",95277357,"G","A","ECM2","Nonsense","Iossifov,2012","yes","Wigler","yes","core",0.159]
["pASD",1,"13590.p1","chr17",28400679,"GT","G","EFCAB5","Frameshift","Iossifov,2012","no","NA","yes","core","NA"]
["pASD",1,"13128.p1","chr1",23236941,"C","T","EPHB2","Nonsense","Sanders,2012","yes","State","yes","core",0.26200000000000001]
["pASD",1,"12752.p1","chr19",51848515,"C","A","ETFB","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",1.4599999999999999E-3]
["pASD",1,"12685.p1","chr6",17606162,"C","T","FAM8A1","Nonsense","Sanders,2012","yes","State","yes","core",9.7099999999999997E-4]
["pASD",1,"12221.p1","chr8",124787443,"C","T","FAM91A1","Nonsense","Iossifov,2012","yes","Wigler","yes","core",1.6100000000000001E-4]
["pASD",1,"12235.p1","chr13",99100552,"AAG","A","FARP1","Frameshift","Novel_indel","yes","State","yes","core",0.20399999999999999]
["pASD",1,"11524.p1","chr1",159778750,"G","A","FCRL6","SpliceSite","Sanders,2012","yes","State","yes","core",0.36499999999999999]
["pASD",1,"13471.p1","chr1",152286920,"CCT","C","FLG","Frameshift","Iossifov,2012","yes","Wigler","yes","extended","NA"]
["pASD",1,"12817.p1","chr3",71050170,"C","CT","FOXP1","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",4.0699999999999998E-3]
["pASD",1,"11074.p1","chr4",144620325,"G","A","FREM3","Nonsense","Sanders,2012","yes","State","yes","extended",4.3400000000000001E-3]
["pASD",1,"13548.p1","chr11",11314690,"TG","T","GALNTL4","Frameshift","Iossifov,2012","yes","State","yes","core",0.161]
["pASD",1,"13096.p1","chr7",150164232,"GA","G","GIMAP8","Frameshift","Iossifov,2012","yes","Wigler","yes","core",0.17]
["pASD",1,"12752.p1","chr5",75902128,"C","T","IQGAP2","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",0.625]
["pASD",1,"10C104461","chr12",54793722,"C","A","ITGA5","Nonsense","Neale,2012","yes","Neale","yes","core",4.0099999999999997E-3]
["pASD",1,"12683.p1","chr17",7749188,"A","G","KDM6B","SpliceSite","Iossifov,2012","yes","State","yes","core",5.96E-3]
["pASD",1,"13346.p1","chr17",26961045,"G","A","KIAA0100","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",2.4400000000000002E-2]
["pASD",1,"12653.p1","chr4",6843914,"C","T","KIAA0232","Nonsense","Iossifov,2012","yes","Wigler","yes","core",8.14E-2]
["pASD",1,"13739.p1","chrX",153135038,"TCA","T","L1CAM","Frameshift","Novel_indel","yes","State","yes","core",6.1999999999999998E-3]
["pASD",1,"13092.p1","chr19",49004781,"A","AAGGTCAG","LMTK3","Frameshift","Iossifov,2012","yes","State","yes","extended",2.7000000000000001E-3]
["pASD",1,"11843.p1","chr21",30318550,"C","A","LTN1","Nonsense","O'Roak,2012a","yes","Eichler","no","NA",0.34799999999999998]
["pASD",1,"11074.p1","chr17",43342072,"TG","T","MAP3K14","Frameshift","Novel_indel","yes","State","yes","core",1.83E-2]
["pASD",1,"12346.p1","chr2",149225965,"GTC","G","MBD5","Frameshift","O'Roak,2012a","yes","Eichler","yes","core","NA"]
["pASD",1,"12969.p1","chr12",116418554,"C","CC","MED13L","SpliceSite","Iossifov,2012","no","NA","yes","core",4.0499999999999998E-4]
["pASD",1,"13168.p1","chr11",119214625,"CT","C","MFRP","Frameshift","Iossifov,2012","yes","Wigler","no","NA","NA"]
["pASD",1,"11148.p1","chr7",151842339,"G","T","MLL3","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",8.0160464000000001E-2]
["pASD",1,"12952.p1","chr7",104748101,"TC","T","MLL5","Frameshift","Iossifov,2012","yes","Wigler","yes","core",0.93200000000000005]
["pASD",1,"12224.p1","chr13",20235898,"C","T","MPHOSPH8","Nonsense","Sanders,2012","yes","State","yes","core",0.33400000000000002]
["pASD",1,"13590.p1","chr15",80137554,"A","AA","MTHFS","Frameshift","Iossifov,2012","yes","Wigler","yes","core",4.44E-4]
["pASD",1,"09C95788","chr5",32263299,"C","T","MTMR12","Nonsense","Neale,2012","yes","Neale","yes","core",1.08E-3]
["pASD",1,"13000.p1","chr17",8424204,"GA","G","MYH10","Frameshift","Novel_indel","yes","State","yes","core",0.60399999999999998]
["pASD",1,"11356.p1","chr8",144659231,"C","T","NAPRT1","SpliceSite","Sanders,2012","yes","State","yes","core",1.5E-3]
["pASD",1,"12764.p1","chr2",183791570,"C","A","NCKAP1","Nonsense","Iossifov,2012","yes","Wigler","yes","core",3.3800000000000002E-3]
["pASD",1,"13670.p1","chr1",61553905,"C","T","NFIA","Nonsense","Iossifov,2012","yes","Wigler","yes","core",4.3899999999999999E-4]
["pASD",1,"11808.p1","chr6",31525439,"C","CTG","NFKBIL1","Frameshift","Novel_indel","yes","State","yes","core",6.7999999999999996E-3]
["pASD",1,"12937.p1","chr4",149073677,"G","T","NR3C2","Nonsense","Iossifov,2012","yes","Wigler","yes","core",5.7300000000000005E-4]
["pASD",1,"12501.p1","chr2",50724605,"A","T","NRXN1","Nonsense","Iossifov,2012","yes","Wigler","yes","core",0.34200000000000003]
["pASD",1,"13349.p1","chr12",106461269,"G","A","NUAK1","Nonsense","Iossifov,2012","yes","Wigler","yes","core",0.41599999999999998]
["pASD",1,"12858.p1","chr9",37015071,"AG","A","PAX5","Frameshift","Iossifov,2012","yes","Wigler","yes","core",1.7899999999999999E-3]
["pASD",1,"12773.p1","chr5",140263887,"CTTCG","C","PCDHA13","Frameshift","Iossifov,2012","yes","Wigler","no","NA",0.129]
["pASD",1,"13018.p1","chr7",100201680,"CT","C","PCOLCE","Frameshift","Iossifov,2012","yes","Wigler","yes","core",1.42E-3]
["pASD",1,"13922.p1","chr3",195966607,"CTAGA","C","PCYT1A","Frameshift","Novel_indel","yes","State","yes","core",0.92600000000000005]
["pASD",1,"11707.p1","chr2",242795103,"TG","T","PDCD1","Frameshift","O'Roak,2012a","yes","Eichler","no","NA",1.07E-3]
["pASD",1,"12323.p1","chr9",96439930,"AT","A","PHF2","Frameshift","Iossifov,2012","yes","Wigler","yes","core",1.6299999999999999E-3]
["pASD",1,"12383.p1","chr3",52454424,"GC","G","PHF7","Frameshift","Novel_indel","yes","State","yes","core",0.60699999999999998]
["pASD",1,"09C97129","chr3",48455355,"CA","C","PLXNB1","Frameshift","Neale,2012","yes","Neale","yes","core",0.152]
["pASD",1,"13333.p1","chr19",630058,"G","A","POLRMT","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",7.3099999999999998E-2]
["pASD",1,"12340.p1","chr17",58740376,"G","A","PPM1D","Nonsense","Sanders,2012","yes","State","yes","core",6.7999999999999999E-5]
["pASD",1,5061.201,"chr1",204380092,"G","A","PPP1R15B","Nonsense","Neale,2012","yes","Neale","yes","core",0.11550000000000001]
["pASD",1,"10C102529","chr14",45571806,"G","A","PRPF39","Nonsense","Neale,2012","yes","Neale","yes","core",2.3499999999999999E-4]
["pASD",1,"11077.p1","chr8",61484622,"C","T","RAB2A","Nonsense","Sanders,2012","yes","State","yes","core",3.5500000000000001E-4]
["pASD",1,"13125.p1","chr20",1210539,"C","T","RAD21L1","Nonsense","Iossifov,2012","yes","Wigler","yes","core",6.9899999999999997E-3]
["pASD",1,"09C90312","chr7",103322603,"G","A","RELN","Nonsense","Neale,2012","yes","Neale","yes","core",1.6896195999999999E-2]
["pASD",1,"13162.p1","chr6",72889392,"A","AA","RIMS1","Frameshift","Iossifov,2012","yes","State","yes","core",2.98E-2]
["pASD",1,"12056.p1","chr9",36375929,"A","G","RNF38","SpliceSite","Sanders,2012","yes","State","yes","core",1.94E-4]
["pASD",1,"13222.p1","chrX",20193403,"G","C","RPS6KA3","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",0.42099999999999999]
["pASD",1,"13135.p1","chrX",16672582,"G","T","S100G","Nonsense","Iossifov,2012","yes","Wigler","yes","core",2.0699999999999998E-5]
["pASD",1,"11712.p1","chr1",53416506,"CTG","C","SCP2","Frameshift","Sanders,2012","yes","State","yes","core",3.9300000000000003E-3]
["pASD",1,"13506.p1","chr11",9111272,"C","A","SCUBE2","Nonsense","Iossifov,2012","yes","Wigler","yes","core",0.81799999999999995]
["pASD",1,"12933.p1","chr18",42532021,"C","CGG","SETBP1","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",1.48E-3]
["pASD",1,"12565.p1","chr3",47098932,"AT","A","SETD2","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",0.72199999999999998]
["pASD",1,"12380.p1","chr11",70332092,"CTG","C","SHANK2","Frameshift","Sanders,2012","yes","State","yes","core",1.41E-2]
["pASD",1,"12939.p1","chr17",42399124,"TCA","T","SLC25A39","Frameshift","Iossifov,2012","yes","Wigler","yes","core",2.0699999999999998E-3]
["pASD",1,"12300.p1","chr14",23243580,"G","A","SLC7A7","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",1.6199999999999999E-3]
["pASD",1,"09C90312","chr12",56566368,"C","A","SMARCC2","SpliceSite","Neale,2012","yes","Neale","yes","core",6.5900000000000004E-3]
["pASD",1,"09C98906","chr2",32361662,"CT","C","SPAST","Frameshift","Neale,2012","yes","Neale","yes","core",2.7599999999999999E-3]
["pASD",1,"12652.p1","chr13",24797448,"GC","G","SPATA13","Frameshift","Iossifov,2012","yes","State","yes","core",0.33700000000000002]
["pASD",1,"5112_201_child","chr2",234969088,"TC","T","SPP2","Frameshift","Neale,2012","yes","Neale","yes","core",0.214]
["pASD",1,"11519.p1","chr11",67938481,"C","T","SUV420H1","SpliceSite","Iossifov,2012","yes","Wigler","yes","core","NA"]
["pASD",1,"13073.p1","chr6",33408650,"CTT","C","SYNGAP1","Frameshift","Novel_indel","yes","State","yes","core",4.9999999999999998E-7]
["pASD",1,"13010.p1","chr3",100015120,"G","C","TBC1D23","SpliceSite","Iossifov,2012","yes","Wigler","yes","core",0.32400000000000001]
["pASD",1,"09C97625","chr19",1619177,"G","GT","TCF3","Frameshift","Neale,2012","yes","Neale","yes","core",1.4400000000000001E-3]
["pASD",1,"13012.s1","chr7",11487022,"G","A","THSD7A","Nonsense","Iossifov,2012","yes","Wigler","yes","extended",0.24199999999999999]
["pASD",1,"12840.p1","chr3",196053904,"C","T","TM4SF19","SpliceSite","Iossifov,2012","yes","Wigler","no","NA",6.8100000000000001E-3]
["pASD",1,"13586.p1","chr1",228596935,"G","GG","TRIM17","Frameshift","Iossifov,2012","no","NA","yes","core",0.76700000000000002]
["pASD",1,"12867.p1","chr2",230701696,"G","A","TRIP12","Nonsense","Iossifov,2012","yes","Wigler","yes","core",3.81E-3]
["pASD",1,"12826.p1","chr1",193045126,"ATTAG","A","TROVE2","Frameshift","Iossifov,2012","no","NA","yes","core",1.64E-3]
["pASD",1,"11510.p1","chr11",2428988,"C","T","TRPM5","SpliceSite","O'Roak,2012a","yes","Eichler","yes","core",0.34699999999999998]
["pASD",1,"11291.p1","chr5",176078840,"C","A","TSPAN17","Nonsense","O'Roak,2012a","yes","Eichler","yes","core",6.5499999999999998E-4]
["pASD",1,"13537.p1","chr15",43694049,"TGTAA","T","TUBGCP4","SpliceSite","Iossifov,2012","yes","Wigler","yes","core",0.16]
["pASD",1,"12950.p1","chr7",138968840,"CCTCT","C","UBN2","Frameshift","Iossifov,2012","yes","Wigler","yes","extended",0.24299999999999999]
["pASD",1,"12161.p1","chr2",170732427,"CAAA","C","UBR3","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",6.9999999999999999E-4]
["pASD",1,"12463.p1","chr2",210745771,"C","T","UNC80","Nonsense","Iossifov,2012","yes","Wigler","yes","core",6.9800000000000001E-3]
["pASD",1,"12521.p1","chr12",62775296,"CTGAG","C","USP15","Frameshift","O'Roak,2012a","yes","Eichler","yes","core",0.497]
["pASD",1,"13646.p1","chr9",35060456,"TAGAAC","T","VCP","Frameshift","Iossifov,2012","yes","Wigler","yes","core",1.9300000000000001E-3]
["pASD",1,"13094.p1","chr4",85715777,"G","A","WDFY3","Nonsense","Iossifov,2012","yes","Wigler","yes","core",0.82799999999999996]
["pASD",1,"13606.s1","chr14",68272015,"GC","G","ZFYVE26","Frameshift","Iossifov,2012","yes","Wigler","yes","core",0.55892237099999997]
["pASD",1,"09C95788","chr13",20641159,"TGTAA","T","ZMYM2","SpliceSite","Neale,2012","yes","Neale","yes","core",6.4899999999999995E-4]
["pASD",1,"13513.p1","chr10",293337,"G","A","ZMYND11","SpliceSite","Iossifov,2012","yes","Wigler","yes","core",6.5300000000000004E-4]
["pASD",1,"12894.p1","chr17",5086039,"G","A","ZNF594","Nonsense","Iossifov,2012","yes","Wigler","yes","extended",0.68799999999999994]

{"sheet":"Burden_LoF","index":2,"n_rows":110,"n_cols":10,"rows_kept":110,"cut":false,"hidden":false,"merged":[]}
["family","sample","chr","pos_hg19","ref","var","pheno","gene","effect","source"]
[13585,"13585.p1","chr12",109577550,"G","GG","Pro","ACACB","Frameshift","Iossifov,2012"]
[12561,"12561.p1","chr20",3655475,"G","A","Pro","ADAM33","Nonsense","Sanders,2012"]
[12645,"12645.p1","chr4",114232545,"C","T","Pro","ANK2","Nonsense","Iossifov,2012"]
[14256,"14256.p1","chr4",114251469,"C","T","Pro","ANK2","Nonsense","56_additional_families"]
[12686,"12686.s1","chr5",55396075,"G","A","Sib","ANKRD55","Nonsense","Iossifov,2012"]
[12792,"12792.p1","chr11",22276997,"C","T","Pro","ANO5","Nonsense","Iossifov,2012"]
[13234,"13234.s1","chr6",101103585,"CT","C","Sib","ASCC3","Frameshift","Iossifov,2012"]
[13616,"13616.p1","chr4",47571001,"G","GG","Pro","ATP10D","Frameshift","Iossifov,2012"]
[12840,"12840.p1","chr1",169096506,"C","T","Pro","ATP1B1","Nonsense","Iossifov,2012"]
[12972,"12972.s1","chrX",76891432,"GAT","A","Sib","ATRX","Frameshift","Iossifov,2012"]
[13183,"13183.p1","chr2",60689254,"G","GG","Pro","BCL11A","Frameshift","Iossifov,2012"]
[11132,"11132.p1","chr6",26508728,"G","A","Pro","BTN1A1","SpliceSite","Sanders,2012"]
[12921,"12921.s1","chr14",77893973,"G","A","Sib","C14orf133","Nonsense","Iossifov,2012"]
[13612,"13612.s1","chr1",244552291,"C","T","Sib","C1orf100","Nonsense","Iossifov,2012"]
[13144,"13144.s1","chr16",1250436,"AG","A","Sib","CACNA1H","Frameshift","Iossifov,2012"]
[13526,"13526.p1","chr3",54921984,"A","G","Pro","CACNA2D3","SpliceSite","Iossifov,2012"]
[13234,"13234.p1","chr17",77809050,"G","A","Pro","CBX4","Nonsense","Iossifov,2012"]
[13319,"13319.s1","chr12",120260716,"GC","G","Sib","CIT","Frameshift","Iossifov,2012"]
[13608,"13608.p1","chr1",115280664,"G","A","Pro","CSDE1","Nonsense","Sanders,2012"]
[12334,"12334.s1","chr5",122911452,"AG","A","Sib","CSNK1G3","Frameshift","Iossifov,2012"]
[13439,"13439.p1","chr10",53458250,"A","AA","Pro","CSTF2T","Frameshift","Iossifov,2012"]
[13070,"13070.p1","chr7",117423008,"TCA","T","Pro","CTTNBP2","Frameshift","Iossifov,2012"]
[12864,"12864.s1","chr4",24534561,"G","A","Sib","DHX15","Nonsense","Iossifov,2012"]
[13012,"13012.p1","chr21",47958430,"C","CCTGGTCT","Pro","DIP2A","Frameshift","Iossifov,2012"]
[12705,"12705.p1","chr10",428609,"C","CC","Pro","DIP2C","Frameshift","Iossifov,2012"]
[12653,"12653.p1","chr6",170593076,"A","AA","Pro","DLL1","Frameshift","Iossifov,2012"]
[13039,"13039.s1","chr10",129183053,"G","C","Sib","DOCK1","SpliceSite","Iossifov,2012"]
[12916,"12916.s1","chr5",169474572,"A","AA","Sib","DOCK2","Frameshift","Iossifov,2012"]
[13131,"13131.s1","chr7",111585777,"AAG","A","Sib","DOCK4","Frameshift","Iossifov,2012"]
[13612,"13612.p1","chr6",56393644,"GGTTT","G","Pro","DST","Frameshift","Iossifov,2012"]
[13552,"13552.p1","chr21",38877834,"GC","G","Pro","DYRK1A","Frameshift","Iossifov,2012"]
[12972,"12972.s1","chr19",4231248,"GC","G","Sib","EBI3","Frameshift","Iossifov,2012"]
[13364,"13364.p1","chr9",95277357,"G","A","Pro","ECM2","Nonsense","Iossifov,2012"]
[13590,"13590.p1","chr17",28400679,"GT","G","Pro","EFCAB5","Frameshift","Iossifov,2012"]
[12462,"12462.s1","chr18",5398076,"G","A","Sib","EPB41L3","Nonsense","Iossifov,2012"]
[13128,"13128.p1","chr1",23236941,"C","T","Pro","EPHB2","Nonsense","Sanders,2012"]
[12838,"12838.s1","chr2",16743297,"A","AA","Sib","FAM49A","Frameshift","Iossifov,2012"]
[14147,"14147.s1","chr2",38231278,"G","C","Sib","FAM82A1","SpliceSite","56_additional_families"]
[12685,"12685.p1","chr6",17606162,"C","T","Pro","FAM8A1","Nonsense","Sanders,2012"]
[12221,"12221.p1","chr8",124787443,"C","T","Pro","FAM91A1","Nonsense","Iossifov,2012"]
[12679,"12679.s1","chr1",157665208,"CAGAG","C","Sib","FCRL3","Frameshift","Iossifov,2012"]
[11524,"11524.p1","chr1",159778750,"G","A","Pro","FCRL6","SpliceSite","Sanders,2012"]
[13471,"13471.p1","chr1",152286920,"CCT","C","Pro","FLG","Frameshift","Iossifov,2012"]
[11074,"11074.p1","chr4",144620325,"G","A","Pro","FREM3","Nonsense","Sanders,2012"]
[13548,"13548.p1","chr11",11314690,"TG","T","Pro","GALNTL4","Frameshift","Iossifov,2012"]
[13096,"13096.p1","chr7",150164232,"GA","G","Pro","GIMAP8","Frameshift","Iossifov,2012"]
[13689,"13689.s1","chr9",95027326,"C","A","Sib","IARS","Nonsense","Iossifov,2012"]
[12867,"12867.s1","chr6",52878774,"G","A","Sib","ICK","Nonsense","Iossifov,2012"]
[11382,"11382.s1","chr9",712165,"G","T","Sib","KANK1","Nonsense","Sanders,2012"]
[11008,"11008.p1","chr18",44589733,"G","A","Pro","KATNAL2","SpliceSite","Sanders,2012"]
[12683,"12683.p1","chr17",7749922,"CG","C","Pro","KDM6B","Frameshift","Iossifov,2012"]
[12653,"12653.p1","chr4",6843914,"C","T","Pro","KIAA0232","Nonsense","Iossifov,2012"]
[13092,"13092.p1","chr19",49004781,"A","AAGGTCAG","Pro","LMTK3","Frameshift","Iossifov,2012"]
[12969,"12969.p1","chr12",116418554,"C","CC","Pro","MED13L","SpliceSite","Iossifov,2012"]
[13168,"13168.p1","chr11",119214625,"CT","C","Pro","MFRP","Frameshift","Iossifov,2012"]
[12952,"12952.p1","chr7",104748101,"TC","T","Pro","MLL5","Frameshift","Iossifov,2012"]
[12224,"12224.p1","chr13",20235898,"C","T","Pro","MPHOSPH8","Nonsense","Sanders,2012"]
[12340,"12340.s1","chr11",73575377,"C","T","Sib","MRPL48","Nonsense","Sanders,2012"]
[13590,"13590.p1","chr15",80137554,"A","AA","Pro","MTHFS","Frameshift","Iossifov,2012"]
[12950,"12950.s1","chr20",20007427,"G","A","Sib","NAA20","SpliceSite","Iossifov,2012"]
[11356,"11356.p1","chr8",144659231,"C","T","Pro","NAPRT1","SpliceSite","Sanders,2012"]
[12764,"12764.p1","chr2",183791570,"C","A","Pro","NCKAP1","Nonsense","Iossifov,2012"]
[13670,"13670.p1","chr1",61553905,"C","T","Pro","NFIA","Nonsense","Iossifov,2012"]
[13197,"13197.p1","chr4",149073677,"G","T","Pro","NR3C2","Nonsense","Iossifov,2012"]
[12501,"12501.p1","chr2",50724605,"A","T","Pro","NRXN1","Nonsense","Iossifov,2012"]
[13349,"13349.p1","chr12",106461269,"G","A","Pro","NUAK1","Nonsense","Iossifov,2012"]
[12858,"12858.p1","chr9",37015071,"AG","A","Pro","PAX5","Frameshift","Iossifov,2012"]
[12773,"12773.p1","chr5",140263887,"CTTCG","C","Pro","PCDHA13","Frameshift","Iossifov,2012"]
[12953,"12953.s1","chr5",140802352,"AT","A","Sib","PCDHGA11","Frameshift","Iossifov,2012"]
[13018,"13018.p1","chr7",100201680,"CT","C","Pro","PCOLCE","Frameshift","Iossifov,2012"]
[12334,"12334.s1","chr4",39900030,"G","T","Sib","PDS5A","Nonsense","Iossifov,2012"]
[12784,"12784.s1","chr6",170105270,"ACC","A","Sib","PHF10","Frameshift","Iossifov,2012"]
[12323,"12323.p1","chr9",96439930,"AT","A","Pro","PHF2","Frameshift","Iossifov,2012"]
[13398,"13398.p1","chr1",151377904,"C","CCGTCATCA","Pro","POGZ","Frameshift","Iossifov,2012"]
[12340,"12340.p1","chr17",58740376,"G","A","Pro","PPM1D","Nonsense","Sanders,2012"]
[13072,"13072.s1","chr10",93390353,"TGA","T","Sib","PPP1R3C","Frameshift","Iossifov,2012"]
[11077,"11077.p1","chr8",61484622,"C","T","Pro","RAB2A","Nonsense","Sanders,2012"]
[14054,"14054.s1","chr7",66236908,"C","T","Sib","RABGEF1","Nonsense","56_additional_families"]
[13125,"13125.p1","chr20",1210539,"C","T","Pro","RAD21L1","Nonsense","Iossifov,2012"]
[13162,"13162.p1","chr6",72889392,"A","AA","Pro","RIMS1","Frameshift","Iossifov,2012"]
[12056,"12056.p1","chr9",36375929,"A","G","Pro","RNF38","SpliceSite","Sanders,2012"]
[11810,"11810.s1","chr3",157920952,"C","T","Sib","RSRC1","Nonsense","Sanders,2012"]
[13135,"13135.p1","chrX",16672582,"G","T","Pro","S100G","Nonsense","Iossifov,2012"]
[11114,"11114.p1","chr2",166210819,"G","T","Pro","SCN2A","Nonsense","Sanders,2012"]
[11892,"11892.p1","chr2",166201379,"C","A","Pro","SCN2A","Nonsense","Sanders,2012"]
[13507,"13507.s1","chr4",141302240,"CAA","C","Sib","SCOC","Frameshift","Iossifov,2012"]
[13506,"13506.p1","chr11",9111272,"C","A","Pro","SCUBE2","Nonsense","Iossifov,2012"]
[11490,"11490.s1","chr1",169582192,"C","T","Sib","SELP","Nonsense","Sanders,2012"]
[12939,"12939.p1","chr17",42399124,"TCA","T","Pro","SLC25A39","Frameshift","Iossifov,2012"]
[12652,"12652.p1","chr13",24797448,"GC","G","Pro","SPATA13","Frameshift","Iossifov,2012"]
[14227,"14227.s1","chr7",99798734,"G","T","Sib","STAG3","Nonsense","56_additional_families"]
[12864,"12864.p1","chr11",67938481,"C","T","Pro","SUV420H1","SpliceSite","Iossifov,2012"]
[11766,"11766.s1","chr6",159104006,"A","T","Sib","SYTL3","Nonsense","Sanders,2012"]
[13010,"13010.p1","chr3",100015120,"G","C","Pro","TBC1D23","SpliceSite","Iossifov,2012"]
[12727,"12727.s1","chr15",57545470,"AT","A","Sib","TCF12","Frameshift","Iossifov,2012"]
[13042,"13042.p1","chr7",11487022,"G","A","Pro","THSD7A","Nonsense","Iossifov,2012"]
[12840,"12840.p1","chr3",196053904,"C","T","Pro","TM4SF19","SpliceSite","Iossifov,2012"]
[13586,"13586.p1","chr1",228596935,"G","GG","Pro","TRIM17","Frameshift","Iossifov,2012"]
[12867,"12867.p1","chr2",230701696,"G","A","Pro","TRIP12","Nonsense","Iossifov,2012"]
[12826,"12826.p1","chr1",193045126,"ATTAG","A","Pro","TROVE2","Frameshift","Iossifov,2012"]
[13537,"13537.p1","chr15",43694049,"TGTAA","T","Pro","TUBGCP4","SpliceSite","Iossifov,2012"]
[12950,"12950.p1","chr7",138968840,"CCTCT","C","Pro","UBN2","Frameshift","Iossifov,2012"]
[12463,"12463.p1","chr2",210745771,"C","T","Pro","UNC80","Nonsense","Iossifov,2012"]
[13646,"13646.p1","chr9",35060456,"TAGAAC","T","Pro","VCP","Frameshift","Iossifov,2012"]
[13094,"13094.p1","chr4",85719152,"T","A","Pro","WDFY3","Nonsense","Iossifov,2012"]
[13176,"13176.p1","chr14",68272015,"GC","G","Pro","ZFYVE26","Frameshift","Iossifov,2012"]
[13513,"13513.p1","chr10",293337,"G","A","Pro","ZMYND11","SpliceSite","Iossifov,2012"]
[12548,"12548.s1","chr19",53352468,"T","C","Sib","ZNF468","SpliceSite","Iossifov,2012"]
[12894,"12894.p1","chr17",5086039,"G","A","Pro","ZNF594","Nonsense","Iossifov,2012"]

{"sheet":"56_families","index":3,"n_rows":57,"n_cols":5,"rows_kept":57,"cut":false,"hidden":false,"merged":[]}
["family","proband_sample","sibling_sample","proband_sex","sibling_sex"]
[14046,"14046.p1","14046.s1","male","male"]
[14051,"14051.p1","14051.s1","male","male"]
[14054,"14054.p1","14054.s1","male","male"]
[14055,"14055.p1","14055.s1","male","male"]
[14058,"14058.p1","14058.s1","male","female"]
[14071,"14071.p1","14071.s1","female","male"]
[14072,"14072.p1","14072.s1","male","female"]
[14183,"14183.p1","14183.s1","male","male"]
[14116,"14116.p1","14116.s1","male","female"]
[14123,"14123.p1","14123.s1","male","female"]
[14128,"14128.p1","14128.s1","female","female"]
[14135,"14135.p1","14135.s1","male","female"]
[14147,"14147.p1","14147.s1","male","female"]
[14155,"14155.p1","14155.s1","male","male"]
[14165,"14165.p1","14165.s1","male","male"]
[14197,"14197.p1","14197.s1","male","male"]
[14198,"14198.p1","14198.s1","male","female"]
[14202,"14202.p1","14202.s1","male","female"]
[14207,"14207.p1","14207.s1","female","male"]
[14208,"14208.p1","14208.s1","male","female"]
[14211,"14211.p1","14211.s1","male","female"]
[14227,"14227.p1","14227.s1","male","male"]
[14237,"14237.p1","14237.s1","male","male"]
[14239,"14239.p1","14239.s1","male","female"]
[14249,"14249.p1","14249.s1","male","female"]
[14254,"14254.p1","14254.s1","male","female"]
[14256,"14256.p1","14256.s1","male","female"]
[14259,"14259.p1","14259.s1","male","male"]
[14260,"14260.p1","14260.s1","male","male"]
[14263,"14263.p1","14263.s1","male","male"]
[14265,"14265.p1","14265.s1","male","male"]
[14075,"14075.p1","14075.s1","male","male"]
[14076,"14076.p1","14076.s1","male","male"]
[14080,"14080.p1","14080.s1","male","female"]
[14084,"14084.p1","14084.s1","male","female"]
[14090,"14090.p1","14090.s1","male","male"]
[14104,"14104.p1","14104.s1","male","male"]
[14108,"14108.p1","14108.s1","male","female"]
[14187,"14187.p1","14187.s1","male","male"]
[11305,"11305.p1","11305.s1","male","male"]
[11309,"11309.p1","11309.s1","male","female"]
[11310,"11310.p1","11310.s1","male","female"]
[11324,"11324.p1","11324.s1","female","male"]
[11325,"11325.p1","11325.s1","male","male"]
[11327,"11327.p1","11327.s1","male","female"]
[11328,"11328.p1","11328.s1","male","female"]
[11330,"11330.p1","11330.s1","male","female"]
[14188,"14188.p1","14188.s1","male","male"]
[14268,"14268.p1","14268.s1","male","female"]
[14285,"14285.p1","14285.s1","male","female"]
[14299,"14299.p1","14299.s1","male","male"]
[14304,"14304.p1","14304.s1","male","female"]
[14305,"14305.p1","14305.s1","male","female"]
[14308,"14308.p1","14308.s1","male","male"]
[14310,"14310.p1","14310.s1","male","male"]
[11284,"11284.p1","11284.s1","male","female"]