Model Information	
Data Set	WORK.WIDE	
Distribution	Poisson	
Link Function	Log	
Dependent Variable	dd4	
Offset Variable	offset4	

Number of Observations Read	1226	
Number of Observations Used	1147	
Missing Values	79	

Class Level Information	
Class	Levels	Values	
NALTREXONE	2	1 0	
THERAPY	2	1 0	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	
Prm1	Intercept			
Prm2	NALTREXONE	1		
Prm3	NALTREXONE	0		
Prm4	THERAPY		1	
Prm5	THERAPY		0	
Prm6	NALTREXONE*THERAPY	1	1	
Prm7	NALTREXONE*THERAPY	1	0	
Prm8	NALTREXONE*THERAPY	0	1	
Prm9	NALTREXONE*THERAPY	0	0	

Criteria For Assessing Goodness Of Fit	
Criterion	DF	Value	Value/DF	
Deviance	1143	12979.1211	11.3553	
Scaled Deviance	1143	12979.1211	11.3553	
Pearson Chi-Square	1143	13409.1055	11.7315	
Scaled Pearson X2	1143	13409.1055	11.7315	
Log Likelihood		7876.1405		
Full Log Likelihood		-7872.1450		
AIC (smaller is better)		15752.2899		
AICC (smaller is better)		15752.3249		
BIC (smaller is better)		15772.4695		

Algorithm converged.	

Analysis Of Maximum Likelihood Parameter Estimates	
Parameter		DF	Estimate	Standard Error	Wald 95% Confidence Limits	Wald Chi-Square	Pr > ChiSq	
Intercept			1	-1.1575	0.0200	-1.1967	-1.1183	3342.81	<.0001	
NALTREXONE	1		1	-0.3272	0.0310	-0.3881	-0.2664	111.11	<.0001	
NALTREXONE	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	1		1	-0.2588	0.0302	-0.3180	-0.1996	73.38	<.0001	
THERAPY	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1	1	0.2915	0.0447	0.2038	0.3792	42.44	<.0001	
NALTREXONE*THERAPY	1	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
Scale			0	1.0000	0.0000	1.0000	1.0000			

Note:	The scale parameter was held fixed.	

LR Statistics For Type 3 Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	66.04	<.0001	
THERAPY	1	25.54	<.0001	
NALTREXONE*THERAPY	1	42.55	<.0001	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.4520	0.02295	-63.28	<.0001	0.05	-1.4970	-1.4070	0.2341	0.005372	
1	0	-1.4847	0.02373	-62.57	<.0001	0.05	-1.5313	-1.4382	0.2266	0.005376	
0	1	-1.4163	0.02263	-62.59	<.0001	0.05	-1.4607	-1.3720	0.2426	0.005490	
0	0	-1.1575	0.02002	-57.82	<.0001	0.05	-1.1967	-1.1183	0.3143	0.006292	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.2238	0.2449	0.2341	0.2238	0.2449	
1	0	0.2163	0.2373	0.2266	0.2163	0.2373	
0	1	0.2321	0.2536	0.2426	0.2321	0.2536	
0	0	0.3022	0.3268	0.3143	0.3022	0.3268	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.03273	0.03301	0.99	0.3214	0.05	
1	1	0	1	-0.03571	0.03223	-1.11	0.2678	0.05	
1	1	0	0	-0.2945	0.03045	-9.67	<.0001	0.05	
1	0	0	1	-0.06844	0.03279	-2.09	0.0369	0.05	
1	0	0	0	-0.3272	0.03105	-10.54	<.0001	0.05	
0	1	0	0	-0.2588	0.03021	-8.57	<.0001	0.05	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.03197	0.09743	1.0333	
1	1	0	1	-0.09888	0.02745	0.9649	
1	1	0	0	-0.3542	-0.2348	0.7449	
1	0	0	1	-0.1327	-0.00418	0.9338	
1	0	0	0	-0.3881	-0.2664	0.7209	
0	1	0	0	-0.3180	-0.1996	0.7720	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.9685	1.1023	
1	1	0	1	0.9059	1.0278	
1	1	0	0	0.7017	0.7907	
1	0	0	1	0.8757	0.9958	
1	0	0	0	0.6783	0.7661	
0	1	0	0	0.7276	0.8191	

Obs	StmtNo	Effect	NALTREXONE	THERAPY	Estimate	StdErr	zValue	
1	1	NALTREXONE*THERAPY	1	1	1.8802	0.02295	-63.28	
2	1	NALTREXONE*THERAPY	1	0	1.8475	0.02373	-62.57	
3	1	NALTREXONE*THERAPY	0	1	1.9159	0.02263	-62.59	
4	1	NALTREXONE*THERAPY	0	0	2.1747	0.02002	-57.82	

Obs	Probz	Alpha	Lower	Upper	ExpEstimate	LowerExp	UpperExp	offset	
1	<.0001	0.05	1.8352	1.9252	6.5547	6.2665	6.8563	3.33220	
2	<.0001	0.05	1.8009	1.8940	6.3437	6.0554	6.6457	3.33220	
3	<.0001	0.05	1.8715	1.9602	6.7930	6.4984	7.1011	3.33220	
4	<.0001	0.05	2.1355	2.2139	8.7996	8.4610	9.1517	3.33220	

Model Information	
Data Set	WORK.WIDE	
Distribution	Binomial	
Link Function	Logit	
Response Variable (Events)	dd4	
Response Variable (Trials)	nonmiss4	

Number of Observations Read	1226	
Number of Observations Used	1147	
Number of Events	8123	
Number of Trials	31940	
Missing Values	79	

Class Level Information	
Class	Levels	Values	
NALTREXONE	2	1 0	
THERAPY	2	1 0	

Response Profile	
Ordered
Value	Binary Outcome	Total
Frequency	
1	Event	8123	
2	Nonevent	23817	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	
Prm1	Intercept			
Prm2	NALTREXONE	1		
Prm3	NALTREXONE	0		
Prm4	THERAPY		1	
Prm5	THERAPY		0	
Prm6	NALTREXONE*THERAPY	1	1	
Prm7	NALTREXONE*THERAPY	1	0	
Prm8	NALTREXONE*THERAPY	0	1	
Prm9	NALTREXONE*THERAPY	0	0	

Criteria For Assessing Goodness Of Fit	
Criterion	DF	Value	Value/DF	
Deviance	1143	19773.2181	17.2994	
Scaled Deviance	1143	19773.2181	17.2994	
Pearson Chi-Square	1143	17984.0080	15.7340	
Scaled Pearson X2	1143	17984.0080	15.7340	
Log Likelihood		-18011.0116		
Full Log Likelihood		-10889.8688		
AIC (smaller is better)		21787.7377		
AICC (smaller is better)		21787.7727		
BIC (smaller is better)		21807.9173		

Algorithm converged.	

Analysis Of Maximum Likelihood Parameter Estimates	
Parameter		DF	Estimate	Standard Error	Wald 95% Confidence Limits	Wald Chi-Square	Pr > ChiSq	
Intercept			1	-0.7802	0.0242	-0.8276	-0.7328	1041.51	<.0001	
NALTREXONE	1		1	-0.4476	0.0362	-0.5186	-0.3766	152.66	<.0001	
NALTREXONE	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	1		1	-0.3582	0.0355	-0.4278	-0.2886	101.79	<.0001	
THERAPY	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1	1	0.4007	0.0517	0.2993	0.5021	60.01	<.0001	
NALTREXONE*THERAPY	1	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
Scale			0	1.0000	0.0000	1.0000	1.0000			

Note:	The scale parameter was held fixed.	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.1853	0.02622	-45.20	<.0001	0.05	-1.2367	-1.1339	0.2341	0.004701	
1	0	-1.2278	0.02698	-45.51	<.0001	0.05	-1.2807	-1.1750	0.2266	0.004728	
0	1	-1.1384	0.02600	-43.78	<.0001	0.05	-1.1894	-1.0875	0.2426	0.004778	
0	0	-0.7802	0.02418	-32.27	<.0001	0.05	-0.8276	-0.7328	0.3143	0.005210	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.2250	0.2434	0.3056	0.2903	0.3218	
1	0	0.2174	0.2360	0.2929	0.2778	0.3088	
0	1	0.2334	0.2521	0.3203	0.3044	0.3371	
0	0	0.3042	0.3246	0.4583	0.4371	0.4805	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.04252	0.03762	1.13	0.2584	0.05	
1	1	0	1	-0.04689	0.03693	-1.27	0.2042	0.05	
1	1	0	0	-0.4051	0.03567	-11.36	<.0001	0.05	
1	0	0	1	-0.08941	0.03747	-2.39	0.0170	0.05	
1	0	0	0	-0.4476	0.03623	-12.36	<.0001	0.05	
0	1	0	0	-0.3582	0.03550	-10.09	<.0001	0.05	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.03122	0.1163	1.0434	
1	1	0	1	-0.1193	0.02549	0.9542	
1	1	0	0	-0.4750	-0.3352	0.6669	
1	0	0	1	-0.1629	-0.01597	0.9145	
1	0	0	0	-0.5186	-0.3766	0.6392	
0	1	0	0	-0.4278	-0.2886	0.6989	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.9693	1.1233	
1	1	0	1	0.8876	1.0258	
1	1	0	0	0.6219	0.7152	
1	0	0	1	0.8497	0.9842	
1	0	0	0	0.5953	0.6862	
0	1	0	0	0.6519	0.7493	

Obs	NALTREXONE	THERAPY	_TYPE_	_FREQ_	_STAT_	predicted	ll	ul	
1	0	0	3	305	MEAN	8.79960	8.51622	9.08801	
2	0	1	3	307	MEAN	6.79304	6.53430	7.05866	
3	1	0	3	302	MEAN	6.34367	6.08796	6.60688	
4	1	1	3	312	MEAN	6.55473	6.30026	6.81626	

Analysis Variable : dd4	
Mean	Variance	
7.0819529	83.8554070	

Analysis Variable : dd4	
NALTREXONE	THERAPY	N Obs	Mean	Std Dev	Variance	
0	0	305	8.7543860	9.8024154	96.0873487	
	1	307	6.7577855	8.8676701	78.6355729	
1	0	302	6.2756184	8.9530893	80.1578077	
	1	312	6.5482759	8.8164333	77.7294953	

Model Information	
Data Set	WORK.WIDE	
Distribution	Poisson	
Link Function	Log	
Dependent Variable	dd4	
Offset Variable	offset4	

Number of Observations Read	1226	
Number of Observations Used	1147	
Missing Values	79	

Class Level Information	
Class	Levels	Values	
NALTREXONE	2	1 0	
THERAPY	2	1 0	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	
Prm1	Intercept			
Prm2	NALTREXONE	1		
Prm3	NALTREXONE	0		
Prm4	THERAPY		1	
Prm5	THERAPY		0	
Prm6	NALTREXONE*THERAPY	1	1	
Prm7	NALTREXONE*THERAPY	1	0	
Prm8	NALTREXONE*THERAPY	0	1	
Prm9	NALTREXONE*THERAPY	0	0	

Criteria For Assessing Goodness Of Fit	
Criterion	DF	Value	Value/DF	
Deviance	1143	12979.1211	11.3553	
Scaled Deviance	1143	1143.0000	1.0000	
Pearson Chi-Square	1143	13409.1055	11.7315	
Scaled Pearson X2	1143	1180.8664	1.0331	
Log Likelihood		693.6085		
Full Log Likelihood		-7872.1450		
AIC (smaller is better)		15752.2899		
AICC (smaller is better)		15752.3249		
BIC (smaller is better)		15772.4695		

Algorithm converged.	

Analysis Of Maximum Likelihood Parameter Estimates	
Parameter		DF	Estimate	Standard Error	Wald 95% Confidence Limits	Wald Chi-Square	Pr > ChiSq	
Intercept			1	-1.1575	0.0675	-1.2897	-1.0253	294.38	<.0001	
NALTREXONE	1		1	-0.3272	0.1046	-0.5323	-0.1222	9.78	0.0018	
NALTREXONE	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	1		1	-0.2588	0.1018	-0.4584	-0.0593	6.46	0.0110	
THERAPY	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1	1	0.2915	0.1508	-0.0040	0.5871	3.74	0.0532	
NALTREXONE*THERAPY	1	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
Scale			0	3.3698	0.0000	3.3698	3.3698			

Note:	The scale parameter was estimated by the square root of DEVIANCE/DOF.	

LR Statistics For Type 3 Analysis	
Source	Num DF	Den DF	F Value	Pr > F	Chi-Square	Pr > ChiSq	
NALTREXONE	1	1143	5.82	0.0160	5.82	0.0159	
THERAPY	1	1143	2.25	0.1340	2.25	0.1337	
NALTREXONE*THERAPY	1	1143	3.75	0.0531	3.75	0.0529	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.4520	0.07733	-18.78	<.0001	0.05	-1.6036	-1.3005	0.2341	0.01810	
1	0	-1.4847	0.07996	-18.57	<.0001	0.05	-1.6415	-1.3280	0.2266	0.01812	
0	1	-1.4163	0.07625	-18.57	<.0001	0.05	-1.5658	-1.2669	0.2426	0.01850	
0	0	-1.1575	0.06746	-17.16	<.0001	0.05	-1.2897	-1.0253	0.3143	0.02120	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.2012	0.2724	0.2341	0.2012	0.2724	
1	0	0.1937	0.2650	0.2266	0.1937	0.2650	
0	1	0.2089	0.2817	0.2426	0.2089	0.2817	
0	0	0.2753	0.3587	0.3143	0.2753	0.3587	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.03273	0.1112	0.29	0.7686	0.05	
1	1	0	1	-0.03571	0.1086	-0.33	0.7423	0.05	
1	1	0	0	-0.2945	0.1026	-2.87	0.0041	0.05	
1	0	0	1	-0.06844	0.1105	-0.62	0.5356	0.05	
1	0	0	0	-0.3272	0.1046	-3.13	0.0018	0.05	
0	1	0	0	-0.2588	0.1018	-2.54	0.0110	0.05	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.1853	0.2507	1.0333	
1	1	0	1	-0.2486	0.1771	0.9649	
1	1	0	0	-0.4956	-0.09339	0.7449	
1	0	0	1	-0.2850	0.1481	0.9338	
1	0	0	0	-0.5323	-0.1222	0.7209	
0	1	0	0	-0.4584	-0.05926	0.7720	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.8309	1.2850	
1	1	0	1	0.7799	1.1938	
1	1	0	0	0.6092	0.9108	
1	0	0	1	0.7520	1.1596	
1	0	0	0	0.5873	0.8850	
0	1	0	0	0.6323	0.9425	

Obs	StmtNo	Effect	NALTREXONE	THERAPY	Estimate	StdErr	zValue	
1	1	NALTREXONE*THERAPY	1	1	1.8802	0.07733	-18.78	
2	1	NALTREXONE*THERAPY	1	0	1.8475	0.07996	-18.57	
3	1	NALTREXONE*THERAPY	0	1	1.9159	0.07625	-18.57	
4	1	NALTREXONE*THERAPY	0	0	2.1747	0.06746	-17.16	

Obs	Probz	Alpha	Lower	Upper	ExpEstimate	LowerExp	UpperExp	offset	
1	<.0001	0.05	1.7286	2.0317	6.5547	5.6329	7.6274	3.33220	
2	<.0001	0.05	1.6907	2.0042	6.3437	5.4235	7.4200	3.33220	
3	<.0001	0.05	1.7664	2.0653	6.7930	5.8500	7.8881	3.33220	
4	<.0001	0.05	2.0425	2.3069	8.7996	7.7097	10.0435	3.33220	

Model Information	
Data Set	WORK.WIDE	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	dd4	
Offset Variable	offset4	

Number of Observations Read	1226	
Number of Observations Used	1147	
Missing Values	79	

Class Level Information	
Class	Levels	Values	
NALTREXONE	2	1 0	
THERAPY	2	1 0	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	
Prm1	Intercept			
Prm2	NALTREXONE	1		
Prm3	NALTREXONE	0		
Prm4	THERAPY		1	
Prm5	THERAPY		0	
Prm6	NALTREXONE*THERAPY	1	1	
Prm7	NALTREXONE*THERAPY	1	0	
Prm8	NALTREXONE*THERAPY	0	1	
Prm9	NALTREXONE*THERAPY	0	0	

Criteria For Assessing Goodness Of Fit	
Criterion	DF	Value	Value/DF	
Deviance	1143	1213.1341	1.0614	
Scaled Deviance	1143	1213.1341	1.0614	
Pearson Chi-Square	1143	664.0192	0.5809	
Scaled Pearson X2	1143	664.0192	0.5809	
Log Likelihood		12523.7139		
Full Log Likelihood		-3224.5716		
AIC (smaller is better)		6459.1432		
AICC (smaller is better)		6459.1957		
BIC (smaller is better)		6484.3677		

Algorithm converged.	

Analysis Of Maximum Likelihood Parameter Estimates	
Parameter		DF	Estimate	Standard Error	Wald 95% Confidence Limits	Wald Chi-Square	Pr > ChiSq	
Intercept			1	-1.1598	0.1005	-1.3568	-0.9627	133.08	<.0001	
NALTREXONE	1		1	-0.3252	0.1431	-0.6056	-0.0448	5.17	0.0230	
NALTREXONE	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	1		1	-0.2581	0.1421	-0.5366	0.0204	3.30	0.0694	
THERAPY	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1	1	0.2908	0.2015	-0.1042	0.6859	2.08	0.1490	
NALTREXONE*THERAPY	1	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
Dispersion			1	2.7662	0.1380	2.5086	3.0503			

Note:	The negative binomial dispersion parameter was estimated by maximum likelihood.	

LR Statistics For Type 3 Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	3.17	0.0749	
THERAPY	1	1.25	0.2638	
NALTREXONE*THERAPY	1	2.08	0.1494	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.4522	0.1003	-14.47	<.0001	0.05	-1.6489	-1.2556	0.2341	0.02348	
1	0	-1.4850	0.1018	-14.59	<.0001	0.05	-1.6845	-1.2855	0.2265	0.02306	
0	1	-1.4178	0.1004	-14.12	<.0001	0.05	-1.6147	-1.2210	0.2422	0.02433	
0	0	-1.1598	0.1005	-11.54	<.0001	0.05	-1.3568	-0.9627	0.3136	0.03152	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.1923	0.2849	0.2341	0.1923	0.2849	
1	0	0.1855	0.2765	0.2265	0.1855	0.2765	
0	1	0.1990	0.2949	0.2422	0.1990	0.2949	
0	0	0.2575	0.3818	0.3136	0.2575	0.3818	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.03277	0.1429	0.23	0.8187	0.05	
1	1	0	1	-0.03437	0.1420	-0.24	0.8087	0.05	
1	1	0	0	-0.2924	0.1420	-2.06	0.0395	0.05	
1	0	0	1	-0.06714	0.1430	-0.47	0.6387	0.05	
1	0	0	0	-0.3252	0.1431	-2.27	0.0230	0.05	
0	1	0	0	-0.2581	0.1421	-1.82	0.0694	0.05	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.2474	0.3129	1.0333	
1	1	0	1	-0.3126	0.2438	0.9662	
1	1	0	0	-0.5708	-0.01406	0.7464	
1	0	0	1	-0.3474	0.2131	0.9351	
1	0	0	0	-0.6056	-0.04477	0.7224	
0	1	0	0	-0.5366	0.02045	0.7725	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.7808	1.3674	
1	1	0	1	0.7315	1.2761	
1	1	0	0	0.5651	0.9860	
1	0	0	1	0.7065	1.2376	
1	0	0	0	0.5457	0.9562	
0	1	0	0	0.5848	1.0207	

Obs	StmtNo	Effect	NALTREXONE	THERAPY	Estimate	StdErr	zValue	
1	1	NALTREXONE*THERAPY	1	1	1.8800	0.1003	-14.47	
2	1	NALTREXONE*THERAPY	1	0	1.8472	0.1018	-14.59	
3	1	NALTREXONE*THERAPY	0	1	1.9144	0.1004	-14.12	
4	1	NALTREXONE*THERAPY	0	0	2.1724	0.1005	-11.54	

Obs	Probz	Alpha	Lower	Upper	ExpEstimate	LowerExp	UpperExp	offset	
1	<.0001	0.05	1.6833	2.0766	6.5534	5.3836	7.9775	3.33220	
2	<.0001	0.05	1.6477	2.0468	6.3421	5.1949	7.7427	3.33220	
3	<.0001	0.05	1.7175	2.1112	6.7826	5.5708	8.2580	3.33220	
4	<.0001	0.05	1.9754	2.3695	8.7795	7.2093	10.6917	3.33220	

Model Information	
Data Set	WORK.WIDE	
Distribution	Binomial	
Link Function	Logit	
Response Variable (Events)	dd4	
Response Variable (Trials)	nonmiss4	

Number of Observations Read	1226	
Number of Observations Used	1147	
Number of Events	8123	
Number of Trials	31940	
Missing Values	79	

Class Level Information	
Class	Levels	Values	
NALTREXONE	2	1 0	
THERAPY	2	1 0	

Response Profile	
Ordered
Value	Binary Outcome	Total
Frequency	
1	Event	8123	
2	Nonevent	23817	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	
Prm1	Intercept			
Prm2	NALTREXONE	1		
Prm3	NALTREXONE	0		
Prm4	THERAPY		1	
Prm5	THERAPY		0	
Prm6	NALTREXONE*THERAPY	1	1	
Prm7	NALTREXONE*THERAPY	1	0	
Prm8	NALTREXONE*THERAPY	0	1	
Prm9	NALTREXONE*THERAPY	0	0	

Criteria For Assessing Goodness Of Fit	
Criterion	DF	Value	Value/DF	
Deviance	1143	19773.2181	17.2994	
Scaled Deviance	1143	1143.0000	1.0000	
Pearson Chi-Square	1143	17984.0080	15.7340	
Scaled Pearson X2	1143	1039.5739	0.9095	
Log Likelihood		-1041.1348		
Full Log Likelihood		-10889.8688		
AIC (smaller is better)		21787.7377		
AICC (smaller is better)		21787.7727		
BIC (smaller is better)		21807.9173		

Algorithm converged.	

Analysis Of Maximum Likelihood Parameter Estimates	
Parameter		DF	Estimate	Standard Error	Wald 95% Confidence Limits	Wald Chi-Square	Pr > ChiSq	
Intercept			1	-0.7802	0.1006	-0.9773	-0.5831	60.20	<.0001	
NALTREXONE	1		1	-0.4476	0.1507	-0.7429	-0.1523	8.82	0.0030	
NALTREXONE	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	1		1	-0.3582	0.1477	-0.6476	-0.0688	5.88	0.0153	
THERAPY	0		0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1	1	0.4007	0.2152	-0.0210	0.8224	3.47	0.0625	
NALTREXONE*THERAPY	1	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0	0	0.0000	0.0000	0.0000	0.0000	.	.	
Scale			0	4.1593	0.0000	4.1593	4.1593			

Note:	The scale parameter was estimated by the square root of DEVIANCE/DOF.	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.1853	0.1091	-10.87	<.0001	0.05	-1.3991	-0.9716	0.2341	0.01955	
1	0	-1.2278	0.1122	-10.94	<.0001	0.05	-1.4478	-1.0079	0.2266	0.01966	
0	1	-1.1384	0.1081	-10.53	<.0001	0.05	-1.3504	-0.9265	0.2426	0.01987	
0	0	-0.7802	0.1006	-7.76	<.0001	0.05	-0.9773	-0.5831	0.3143	0.02167	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.1980	0.2746	0.3056	0.2468	0.3785	
1	0	0.1903	0.2674	0.2929	0.2351	0.3650	
0	1	0.2058	0.2836	0.3203	0.2591	0.3959	
0	0	0.2734	0.3582	0.4583	0.3763	0.5581	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.04252	0.1565	0.27	0.7858	0.05	
1	1	0	1	-0.04689	0.1536	-0.31	0.7602	0.05	
1	1	0	0	-0.4051	0.1483	-2.73	0.0063	0.05	
1	0	0	1	-0.08941	0.1558	-0.57	0.5662	0.05	
1	0	0	0	-0.4476	0.1507	-2.97	0.0030	0.05	
0	1	0	0	-0.3582	0.1477	-2.43	0.0153	0.05	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.2642	0.3492	1.0434	
1	1	0	1	-0.3479	0.2541	0.9542	
1	1	0	0	-0.6958	-0.1143	0.6669	
1	0	0	1	-0.3949	0.2160	0.9145	
1	0	0	0	-0.7429	-0.1523	0.6392	
0	1	0	0	-0.6476	-0.06878	0.6989	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.7678	1.4180	
1	1	0	1	0.7062	1.2894	
1	1	0	0	0.4987	0.8920	
1	0	0	1	0.6738	1.2412	
1	0	0	0	0.4757	0.8587	
0	1	0	0	0.5233	0.9335	

Obs	NALTREXONE	THERAPY	_TYPE_	_FREQ_	_STAT_	predicted	ll	ul	
1	0	0	3	305	MEAN	8.79960	7.65593	10.0299	
2	0	1	3	307	MEAN	6.79304	5.76259	7.9420	
3	1	0	3	302	MEAN	6.34367	5.32956	7.4870	
4	1	1	3	312	MEAN	6.55473	5.54298	7.6879	

Model Information	
Data Set	WORK.LONG	
Distribution	Binomial	
Link Function	Logit	
Response Variable (Events)	ndr	
Response Variable (Trials)	nonmiss	

Number of Observations Read	4904	
Number of Observations Used	4712	
Number of Events	31478	
Number of Trials	130675	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Response Profile	
Ordered
Value	Binary Outcome	Total
Frequency	
1	Event	31478	
2	Nonevent	99197	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Independent	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	391.6581	
QICu	391.5378	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.1853	0.1030	-1.3873	-0.9834	-11.50	<.0001	
NALTREXONE	0			0.0469	0.1447	-0.2368	0.3305	0.32	0.7460	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			-0.0425	0.1502	-0.3368	0.2518	-0.28	0.7770	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.4007	0.2053	-0.0017	0.8032	1.95	0.0510	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0044	0.0796	-0.1605	0.1517	-0.05	0.9562	
month	2			0.0853	0.0701	-0.0521	0.2226	1.22	0.2237	
month	3			0.0208	0.0562	-0.0895	0.1310	0.37	0.7118	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.2221	0.1165	-0.4505	0.0064	-1.91	0.0567	
NALTREXONE*month	0	2		-0.1196	0.0950	-0.3057	0.0666	-1.26	0.2080	
NALTREXONE*month	0	3		-0.0660	0.0754	-0.2138	0.0818	-0.87	0.3818	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2600	0.1232	-0.5014	-0.0186	-2.11	0.0348	
THERAPY*month	0	2		-0.1206	0.1019	-0.3204	0.0791	-1.18	0.2364	
THERAPY*month	0	3		-0.0362	0.0752	-0.1836	0.1112	-0.48	0.6302	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.0575	0.1674	-0.2707	0.3857	0.34	0.7314	
NALTRE*THERAPY*month	0	0	2	0.0262	0.1343	-0.2369	0.2894	0.20	0.8450	
NALTRE*THERAPY*month	0	0	3	0.0152	0.1001	-0.1810	0.2114	0.15	0.8793	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	3.06	0.0802	
THERAPY	1	0.54	0.4641	
NALTREXONE*THERAPY	1	5.55	0.0185	
month	3	46.66	<.0001	
NALTREXONE*month	3	5.41	0.1439	
THERAPY*month	3	7.96	0.0469	
NALTRE*THERAPY*month	3	0.12	0.9887	

Model Information	
Data Set	WORK.LONG	
Distribution	Poisson	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Independent	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	-5226.5400	
QICu	-5226.6502	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4520	0.0789	-1.6067	-1.2973	-18.40	<.0001	
NALTREXONE	0			0.0357	0.1102	-0.1803	0.2518	0.32	0.7460	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			-0.0327	0.1156	-0.2593	0.1939	-0.28	0.7771	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2915	0.1538	-0.0099	0.5930	1.90	0.0580	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0034	0.0610	-0.1229	0.1162	-0.05	0.9562	
month	2			0.0646	0.0533	-0.0397	0.1690	1.21	0.2249	
month	3			0.0159	0.0430	-0.0684	0.1001	0.37	0.7119	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1727	0.0899	-0.3488	0.0034	-1.92	0.0546	
NALTREXONE*month	0	2		-0.0907	0.0722	-0.2322	0.0507	-1.26	0.2087	
NALTREXONE*month	0	3		-0.0503	0.0575	-0.1630	0.0624	-0.87	0.3820	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2069	0.0960	-0.3951	-0.0188	-2.16	0.0311	
THERAPY*month	0	2		-0.0921	0.0783	-0.2456	0.0613	-1.18	0.2394	
THERAPY*month	0	3		-0.0278	0.0578	-0.1412	0.0855	-0.48	0.6304	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.0701	0.1286	-0.1819	0.3222	0.55	0.5855	
NALTRE*THERAPY*month	0	0	2	0.0282	0.1011	-0.1700	0.2264	0.28	0.7804	
NALTRE*THERAPY*month	0	0	3	0.0164	0.0754	-0.1314	0.1642	0.22	0.8281	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.94	0.0862	
THERAPY	1	0.44	0.5049	
NALTREXONE*THERAPY	1	5.45	0.0195	
month	3	45.81	<.0001	
NALTREXONE*month	3	4.67	0.1973	
THERAPY*month	3	7.44	0.0592	
NALTRE*THERAPY*month	3	0.33	0.9552	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Independent	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	-152712.3387	
QICu	-152712.2600	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4522	0.0789	-1.6068	-1.2976	-18.41	<.0001	
NALTREXONE	0			0.0344	0.1102	-0.1815	0.2503	0.31	0.7550	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			-0.0328	0.1152	-0.2586	0.1930	-0.28	0.7759	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2909	0.1535	-0.0099	0.5917	1.90	0.0581	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0003	0.0610	-0.1199	0.1193	-0.01	0.9959	
month	2			0.0682	0.0533	-0.0364	0.1727	1.28	0.2013	
month	3			0.0165	0.0437	-0.0691	0.1021	0.38	0.7059	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1726	0.0898	-0.3486	0.0033	-1.92	0.0545	
NALTREXONE*month	0	2		-0.0941	0.0725	-0.2361	0.0479	-1.30	0.1942	
NALTREXONE*month	0	3		-0.0500	0.0579	-0.1635	0.0635	-0.86	0.3881	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2103	0.0961	-0.3987	-0.0220	-2.19	0.0286	
THERAPY*month	0	2		-0.0799	0.0780	-0.2329	0.0730	-1.02	0.3057	
THERAPY*month	0	3		-0.0260	0.0579	-0.1396	0.0875	-0.45	0.6533	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.0774	0.1288	-0.1750	0.3299	0.60	0.5478	
NALTRE*THERAPY*month	0	0	2	0.0125	0.1012	-0.1859	0.2108	0.12	0.9020	
NALTRE*THERAPY*month	0	0	3	0.0225	0.0759	-0.1262	0.1712	0.30	0.7666	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.84	0.0921	
THERAPY	1	0.49	0.4847	
NALTREXONE*THERAPY	1	5.47	0.0194	
month	3	45.64	<.0001	
NALTREXONE*month	3	4.48	0.2140	
THERAPY*month	3	7.62	0.0545	
NALTRE*THERAPY*month	3	0.64	0.8881	

Model Information	
Data Set	WORK.LONG	
Distribution	Binomial	
Link Function	Logit	
Response Variable (Events)	ndr	
Response Variable (Trials)	nonmiss	

Number of Observations Read	4904	
Number of Observations Used	4712	
Number of Events	31478	
Number of Trials	130675	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Response Profile	
Ordered
Value	Binary Outcome	Total
Frequency	
1	Event	31478	
2	Nonevent	99197	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Exchangeable	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

Exchangeable Working Correlation	
Correlation	0.7890281127	

GEE Fit Criteria	
QIC	392.2714	
QICu	392.5675	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.1920	0.1014	-1.3908	-0.9933	-11.76	<.0001	
NALTREXONE	0			0.0545	0.1426	-0.2250	0.3341	0.38	0.7023	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			0.0165	0.1477	-0.2729	0.3060	0.11	0.9109	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.3248	0.2019	-0.0709	0.7206	1.61	0.1077	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0049	0.0796	-0.1608	0.1511	-0.06	0.9512	
month	2			0.0870	0.0703	-0.0509	0.2248	1.24	0.2163	
month	3			0.0200	0.0565	-0.0908	0.1308	0.35	0.7240	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.2264	0.1159	-0.4535	0.0007	-1.95	0.0507	
NALTREXONE*month	0	2		-0.1207	0.0950	-0.3069	0.0655	-1.27	0.2039	
NALTREXONE*month	0	3		-0.0630	0.0756	-0.2110	0.0851	-0.83	0.4046	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2952	0.1196	-0.5296	-0.0608	-2.47	0.0136	
THERAPY*month	0	2		-0.1442	0.0986	-0.3376	0.0491	-1.46	0.1436	
THERAPY*month	0	3		-0.0477	0.0730	-0.1908	0.0953	-0.65	0.5133	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1093	0.1642	-0.2124	0.4311	0.67	0.5054	
NALTRE*THERAPY*month	0	0	2	0.0522	0.1311	-0.2048	0.3092	0.40	0.6906	
NALTRE*THERAPY*month	0	0	3	0.0315	0.0982	-0.1610	0.2240	0.32	0.7482	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.40	0.1215	
THERAPY	1	0.82	0.3641	
NALTREXONE*THERAPY	1	4.34	0.0373	
month	3	50.08	<.0001	
NALTREXONE*month	3	4.37	0.2240	
THERAPY*month	3	8.79	0.0323	
NALTRE*THERAPY*month	3	0.47	0.9264	

Model Information	
Data Set	WORK.LONG	
Distribution	Poisson	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Exchangeable	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

Exchangeable Working Correlation	
Correlation	0.7883124968	

GEE Fit Criteria	
QIC	-5246.9405	
QICu	-5246.6488	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4570	0.0778	-1.6095	-1.3046	-18.73	<.0001	
NALTREXONE	0			0.0414	0.1087	-0.1717	0.2544	0.38	0.7036	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			0.0134	0.1130	-0.2081	0.2350	0.12	0.9054	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2330	0.1509	-0.0628	0.5288	1.54	0.1226	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0037	0.0611	-0.1234	0.1159	-0.06	0.9511	
month	2			0.0660	0.0535	-0.0389	0.1709	1.23	0.2177	
month	3			0.0153	0.0433	-0.0696	0.1001	0.35	0.7244	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1761	0.0894	-0.3515	-0.0008	-1.97	0.0489	
NALTREXONE*month	0	2		-0.0916	0.0722	-0.2332	0.0500	-1.27	0.2048	
NALTREXONE*month	0	3		-0.0480	0.0577	-0.1610	0.0650	-0.83	0.4054	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2342	0.0928	-0.4161	-0.0522	-2.52	0.0117	
THERAPY*month	0	2		-0.1105	0.0754	-0.2582	0.0373	-1.47	0.1428	
THERAPY*month	0	3		-0.0368	0.0559	-0.1463	0.0728	-0.66	0.5106	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1095	0.1259	-0.1374	0.3563	0.87	0.3847	
NALTRE*THERAPY*month	0	0	2	0.0480	0.0985	-0.1451	0.2411	0.49	0.6259	
NALTRE*THERAPY*month	0	0	3	0.0285	0.0738	-0.1162	0.1732	0.39	0.6993	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.27	0.1321	
THERAPY	1	0.72	0.3949	
NALTREXONE*THERAPY	1	4.23	0.0397	
month	3	49.46	<.0001	
NALTREXONE*month	3	3.71	0.2941	
THERAPY*month	3	8.26	0.0410	
NALTRE*THERAPY*month	3	0.80	0.8494	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Exchangeable	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

Exchangeable Working Correlation	
Correlation	0.780926189	

GEE Fit Criteria	
QIC	-154124.2908	
QICu	-154123.6003	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4511	0.0769	-1.6018	-1.3004	-18.87	<.0001	
NALTREXONE	0			0.0374	0.1078	-0.1739	0.2486	0.35	0.7287	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			-0.0011	0.1117	-0.2200	0.2178	-0.01	0.9920	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2485	0.1497	-0.0450	0.5420	1.66	0.0970	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0046	0.0606	-0.1234	0.1142	-0.08	0.9394	
month	2			0.0669	0.0532	-0.0373	0.1711	1.26	0.2085	
month	3			0.0158	0.0432	-0.0689	0.1005	0.37	0.7145	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1724	0.0889	-0.3466	0.0018	-1.94	0.0524	
NALTREXONE*month	0	2		-0.0910	0.0718	-0.2318	0.0498	-1.27	0.2052	
NALTREXONE*month	0	3		-0.0473	0.0575	-0.1599	0.0653	-0.82	0.4103	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2363	0.0929	-0.4183	-0.0543	-2.55	0.0109	
THERAPY*month	0	2		-0.1035	0.0751	-0.2507	0.0437	-1.38	0.1681	
THERAPY*month	0	3		-0.0355	0.0559	-0.1451	0.0741	-0.64	0.5254	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1137	0.1257	-0.1327	0.3601	0.90	0.3658	
NALTRE*THERAPY*month	0	0	2	0.0378	0.0981	-0.1545	0.2301	0.39	0.7000	
NALTRE*THERAPY*month	0	0	3	0.0307	0.0737	-0.1138	0.1752	0.42	0.6770	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.52	0.1126	
THERAPY	1	0.60	0.4394	
NALTREXONE*THERAPY	1	4.76	0.0291	
month	3	50.08	<.0001	
NALTREXONE*month	3	3.40	0.3340	
THERAPY*month	3	8.35	0.0393	
NALTRE*THERAPY*month	3	1.01	0.8000	

Model Information	
Data Set	WORK.LONG	
Distribution	Binomial	
Link Function	Logit	
Response Variable (Events)	ndr	
Response Variable (Trials)	nonmiss	

Number of Observations Read	4904	
Number of Observations Used	4712	
Number of Events	31478	
Number of Trials	130675	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Response Profile	
Ordered
Value	Binary Outcome	Total
Frequency	
1	Event	31478	
2	Nonevent	99197	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	AR(1)	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	392.2653	
QICu	392.3143	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.2024	0.1018	-1.4020	-1.0028	-11.81	<.0001	
NALTREXONE	0			0.0626	0.1430	-0.2177	0.3428	0.44	0.6617	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			0.0203	0.1485	-0.2707	0.3112	0.14	0.8913	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.3348	0.2027	-0.0625	0.7321	1.65	0.0986	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0019	0.0801	-0.1589	0.1552	-0.02	0.9814	
month	2			0.0879	0.0706	-0.0504	0.2263	1.25	0.2129	
month	3			0.0208	0.0567	-0.0904	0.1321	0.37	0.7133	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.2325	0.1161	-0.4601	-0.0048	-2.00	0.0453	
NALTREXONE*month	0	2		-0.1237	0.0951	-0.3102	0.0628	-1.30	0.1935	
NALTREXONE*month	0	3		-0.0638	0.0758	-0.2123	0.0847	-0.84	0.3999	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2923	0.1197	-0.5269	-0.0576	-2.44	0.0147	
THERAPY*month	0	2		-0.1355	0.0990	-0.3296	0.0586	-1.37	0.1712	
THERAPY*month	0	3		-0.0389	0.0732	-0.1824	0.1047	-0.53	0.5954	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1061	0.1638	-0.2150	0.4272	0.65	0.5172	
NALTRE*THERAPY*month	0	0	2	0.0419	0.1311	-0.2150	0.2989	0.32	0.7490	
NALTRE*THERAPY*month	0	0	3	0.0237	0.0984	-0.1691	0.2166	0.24	0.8095	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.65	0.1035	
THERAPY	1	1.05	0.3046	
NALTREXONE*THERAPY	1	4.40	0.0360	
month	3	50.01	<.0001	
NALTREXONE*month	3	4.80	0.1869	
THERAPY*month	3	8.87	0.0310	
NALTRE*THERAPY*month	3	0.46	0.9273	

Model Information	
Data Set	WORK.LONG	
Distribution	Poisson	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	AR(1)	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	-5242.2569	
QICu	-5242.1961	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4647	0.0783	-1.6181	-1.3112	-18.71	<.0001	
NALTREXONE	0			0.0473	0.1091	-0.1666	0.2612	0.43	0.6646	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			0.0151	0.1138	-0.2079	0.2382	0.13	0.8941	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2411	0.1515	-0.0559	0.5381	1.59	0.1116	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0014	0.0616	-0.1222	0.1193	-0.02	0.9813	
month	2			0.0668	0.0538	-0.0387	0.1723	1.24	0.2147	
month	3			0.0160	0.0435	-0.0693	0.1013	0.37	0.7136	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1808	0.0898	-0.3568	-0.0049	-2.01	0.0439	
NALTREXONE*month	0	2		-0.0940	0.0725	-0.2360	0.0480	-1.30	0.1946	
NALTREXONE*month	0	3		-0.0487	0.0579	-0.1622	0.0648	-0.84	0.4007	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2314	0.0931	-0.4138	-0.0489	-2.49	0.0129	
THERAPY*month	0	2		-0.1033	0.0758	-0.2519	0.0453	-1.36	0.1732	
THERAPY*month	0	3		-0.0297	0.0562	-0.1398	0.0804	-0.53	0.5965	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1068	0.1258	-0.1397	0.3533	0.85	0.3958	
NALTRE*THERAPY*month	0	0	2	0.0397	0.0986	-0.1536	0.2330	0.40	0.6872	
NALTRE*THERAPY*month	0	0	3	0.0221	0.0740	-0.1230	0.1672	0.30	0.7652	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.51	0.1131	
THERAPY	1	0.92	0.3367	
NALTREXONE*THERAPY	1	4.30	0.0381	
month	3	49.35	<.0001	
NALTREXONE*month	3	4.14	0.2471	
THERAPY*month	3	8.30	0.0402	
NALTRE*THERAPY*month	3	0.80	0.8493	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	AR(1)	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	-153977.5896	
QICu	-153976.8809	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4528	0.0774	-1.6044	-1.3012	-18.78	<.0001	
NALTREXONE	0			0.0389	0.1081	-0.1729	0.2508	0.36	0.7186	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			-0.0068	0.1121	-0.2265	0.2129	-0.06	0.9517	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2593	0.1500	-0.0346	0.5532	1.73	0.0838	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0039	0.0609	-0.1233	0.1155	-0.06	0.9494	
month	2			0.0672	0.0534	-0.0374	0.1718	1.26	0.2080	
month	3			0.0177	0.0429	-0.0665	0.1018	0.41	0.6805	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1732	0.0888	-0.3473	0.0010	-1.95	0.0513	
NALTREXONE*month	0	2		-0.0909	0.0719	-0.2318	0.0500	-1.26	0.2062	
NALTREXONE*month	0	3		-0.0483	0.0573	-0.1606	0.0640	-0.84	0.3992	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2314	0.0930	-0.4136	-0.0492	-2.49	0.0128	
THERAPY*month	0	2		-0.0973	0.0756	-0.2456	0.0509	-1.29	0.1981	
THERAPY*month	0	3		-0.0300	0.0557	-0.1393	0.0792	-0.54	0.5902	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1047	0.1255	-0.1413	0.3508	0.83	0.4042	
NALTRE*THERAPY*month	0	0	2	0.0268	0.0982	-0.1657	0.2193	0.27	0.7847	
NALTRE*THERAPY*month	0	0	3	0.0210	0.0735	-0.1232	0.1651	0.29	0.7756	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.65	0.1036	
THERAPY	1	0.60	0.4383	
NALTREXONE*THERAPY	1	4.86	0.0274	
month	3	50.11	<.0001	
NALTREXONE*month	3	3.80	0.2844	
THERAPY*month	3	8.39	0.0386	
NALTRE*THERAPY*month	3	0.92	0.8211	

Model Information	
Data Set	WORK.LONG	
Distribution	Binomial	
Link Function	Logit	
Response Variable (Events)	ndr	
Response Variable (Trials)	nonmiss	

Number of Observations Read	4904	
Number of Observations Used	4712	
Number of Events	31478	
Number of Trials	130675	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Response Profile	
Ordered
Value	Binary Outcome	Total
Frequency	
1	Event	31478	
2	Nonevent	99197	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Unstructured	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	394.3666	
QICu	392.7237	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.2097	0.1024	-1.4105	-1.0090	-11.81	<.0001	
NALTREXONE	0			0.0721	0.1436	-0.2093	0.3535	0.50	0.6154	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			0.0506	0.1545	-0.2522	0.3535	0.33	0.7431	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2912	0.2078	-0.1162	0.6986	1.40	0.1612	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			0.0021	0.0804	-0.1555	0.1598	0.03	0.9788	
month	2			0.0885	0.0709	-0.0504	0.2275	1.25	0.2117	
month	3			0.0214	0.0569	-0.0902	0.1330	0.38	0.7066	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.2345	0.1163	-0.4624	-0.0066	-2.02	0.0437	
NALTREXONE*month	0	2		-0.1233	0.0953	-0.3101	0.0634	-1.29	0.1956	
NALTREXONE*month	0	3		-0.0635	0.0759	-0.2122	0.0852	-0.84	0.4025	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.3055	0.1193	-0.5394	-0.0716	-2.56	0.0105	
THERAPY*month	0	2		-0.1409	0.0985	-0.3340	0.0522	-1.43	0.1527	
THERAPY*month	0	3		-0.0420	0.0730	-0.1852	0.1012	-0.57	0.5654	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1212	0.1637	-0.1997	0.4421	0.74	0.4590	
NALTRE*THERAPY*month	0	0	2	0.0501	0.1307	-0.2062	0.3063	0.38	0.7018	
NALTRE*THERAPY*month	0	0	3	0.0277	0.0983	-0.1649	0.2204	0.28	0.7778	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.21	0.1372	
THERAPY	1	1.13	0.2871	
NALTREXONE*THERAPY	1	3.39	0.0656	
month	3	43.88	<.0001	
NALTREXONE*month	3	4.52	0.2103	
THERAPY*month	3	9.26	0.0261	
NALTRE*THERAPY*month	3	0.59	0.8988	

Model Information	
Data Set	WORK.LONG	
Distribution	Poisson	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Unstructured	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Algorithm converged.	

GEE Fit Criteria	
QIC	-5248.4716	
QICu	-5249.3663	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4689	0.0787	-1.6231	-1.3147	-18.67	<.0001	
NALTREXONE	0			0.0533	0.1094	-0.1612	0.2678	0.49	0.6263	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			0.0330	0.1161	-0.1945	0.2606	0.28	0.7761	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2169	0.1535	-0.0840	0.5178	1.41	0.1577	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			0.0009	0.0618	-0.1203	0.1220	0.01	0.9885	
month	2			0.0673	0.0541	-0.0387	0.1732	1.24	0.2136	
month	3			0.0164	0.0437	-0.0692	0.1020	0.38	0.7074	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1817	0.0898	-0.3578	-0.0057	-2.02	0.0430	
NALTREXONE*month	0	2		-0.0937	0.0725	-0.2359	0.0485	-1.29	0.1966	
NALTREXONE*month	0	3		-0.0485	0.0580	-0.1621	0.0652	-0.84	0.4031	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2394	0.0926	-0.4208	-0.0579	-2.59	0.0097	
THERAPY*month	0	2		-0.1072	0.0754	-0.2551	0.0406	-1.42	0.1550	
THERAPY*month	0	3		-0.0324	0.0560	-0.1422	0.0774	-0.58	0.5629	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1150	0.1255	-0.1309	0.3609	0.92	0.3593	
NALTRE*THERAPY*month	0	0	2	0.0450	0.0983	-0.1477	0.2376	0.46	0.6474	
NALTRE*THERAPY*month	0	0	3	0.0253	0.0739	-0.1196	0.1701	0.34	0.7323	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.25	0.1332	
THERAPY	1	1.01	0.3154	
NALTREXONE*THERAPY	1	3.61	0.0573	
month	3	44.46	<.0001	
NALTREXONE*month	3	3.94	0.2680	
THERAPY*month	3	8.65	0.0344	
NALTRE*THERAPY*month	3	0.91	0.8223	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	
month	4	1 2 3 4	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	0			
Prm3	NALTREXONE	1			
Prm4	THERAPY		0		
Prm5	THERAPY		1		
Prm6	NALTREXONE*THERAPY	0	0		
Prm7	NALTREXONE*THERAPY	0	1		
Prm8	NALTREXONE*THERAPY	1	0		
Prm9	NALTREXONE*THERAPY	1	1		
Prm10	month			1	
Prm11	month			2	
Prm12	month			3	
Prm13	month			4	
Prm14	NALTREXONE*month	0		1	
Prm15	NALTREXONE*month	0		2	
Prm16	NALTREXONE*month	0		3	
Prm17	NALTREXONE*month	0		4	
Prm18	NALTREXONE*month	1		1	
Prm19	NALTREXONE*month	1		2	
Prm20	NALTREXONE*month	1		3	
Prm21	NALTREXONE*month	1		4	
Prm22	THERAPY*month		0	1	
Prm23	THERAPY*month		0	2	
Prm24	THERAPY*month		0	3	
Prm25	THERAPY*month		0	4	
Prm26	THERAPY*month		1	1	
Prm27	THERAPY*month		1	2	
Prm28	THERAPY*month		1	3	
Prm29	THERAPY*month		1	4	
Prm30	NALTRE*THERAPY*month	0	0	1	
Prm31	NALTRE*THERAPY*month	0	0	2	
Prm32	NALTRE*THERAPY*month	0	0	3	
Prm33	NALTRE*THERAPY*month	0	0	4	
Prm34	NALTRE*THERAPY*month	0	1	1	
Prm35	NALTRE*THERAPY*month	0	1	2	
Prm36	NALTRE*THERAPY*month	0	1	3	
Prm37	NALTRE*THERAPY*month	0	1	4	
Prm38	NALTRE*THERAPY*month	1	0	1	
Prm39	NALTRE*THERAPY*month	1	0	2	
Prm40	NALTRE*THERAPY*month	1	0	3	
Prm41	NALTRE*THERAPY*month	1	0	4	
Prm42	NALTRE*THERAPY*month	1	1	1	
Prm43	NALTRE*THERAPY*month	1	1	2	
Prm44	NALTRE*THERAPY*month	1	1	3	
Prm45	NALTRE*THERAPY*month	1	1	4	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Unstructured	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Covariance Matrix (Model-Based)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.005464	-0.005464	-0.005464	0.005464	-0.001883	-0.001246	-0.000577	0.001883	0.001246	
Prm2	-0.005464	0.01097	0.005464	-0.01097	0.001883	0.001246	0.0005770	-0.003746	-0.002474	
Prm4	-0.005464	0.005464	0.01106	-0.01106	0.001883	0.001246	0.0005770	-0.001883	-0.001246	
Prm6	0.005464	-0.01097	-0.01106	0.02202	-0.001883	-0.001246	-0.000577	0.003746	0.002474	
Prm10	-0.001883	0.001883	0.001883	-0.001883	0.003603	0.001987	0.0007548	-0.003603	-0.001987	
Prm11	-0.001246	0.001246	0.001246	-0.001246	0.001987	0.002373	0.0009286	-0.001987	-0.002373	
Prm12	-0.000577	0.0005770	0.0005770	-0.000577	0.0007548	0.0009286	0.001124	-0.000755	-0.000929	
Prm14	0.001883	-0.003746	-0.001883	0.003746	-0.003603	-0.001987	-0.000755	0.007246	0.003987	
Prm15	0.001246	-0.002474	-0.001246	0.002474	-0.001987	-0.002373	-0.000929	0.003987	0.004766	
Prm16	0.0005770	-0.001147	-0.000577	0.001147	-0.000755	-0.000929	-0.001124	0.001509	0.001859	
Prm22	0.001883	-0.001883	-0.003777	0.003777	-0.003603	-0.001987	-0.000755	0.003603	0.001987	
Prm23	0.001246	-0.001246	-0.002511	0.002511	-0.001987	-0.002373	-0.000929	0.001987	0.002373	
Prm24	0.0005770	-0.000577	-0.001175	0.001175	-0.000755	-0.000929	-0.001124	0.0007548	0.0009286	
Prm30	-0.001883	0.003746	0.003777	-0.007477	0.003603	0.001987	0.0007548	-0.007246	-0.003987	
Prm31	-0.001246	0.002474	0.002511	-0.004969	0.001987	0.002373	0.0009286	-0.003987	-0.004766	
Prm32	-0.000577	0.001147	0.001175	-0.002324	0.0007548	0.0009286	0.001124	-0.001509	-0.001859	

Covariance Matrix (Model-Based)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.0005770	0.001883	0.001246	0.0005770	-0.001883	-0.001246	-0.000577	
Prm2	-0.001147	-0.001883	-0.001246	-0.000577	0.003746	0.002474	0.001147	
Prm4	-0.000577	-0.003777	-0.002511	-0.001175	0.003777	0.002511	0.001175	
Prm6	0.001147	0.003777	0.002511	0.001175	-0.007477	-0.004969	-0.002324	
Prm10	-0.000755	-0.003603	-0.001987	-0.000755	0.003603	0.001987	0.0007548	
Prm11	-0.000929	-0.001987	-0.002373	-0.000929	0.001987	0.002373	0.0009286	
Prm12	-0.001124	-0.000755	-0.000929	-0.001124	0.0007548	0.0009286	0.001124	
Prm14	0.001509	0.003603	0.001987	0.0007548	-0.007246	-0.003987	-0.001509	
Prm15	0.001859	0.001987	0.002373	0.0009286	-0.003987	-0.004766	-0.001859	
Prm16	0.002251	0.0007548	0.0009286	0.001124	-0.001509	-0.001859	-0.002251	
Prm22	0.0007548	0.007315	0.004036	0.001535	-0.007315	-0.004036	-0.001535	
Prm23	0.0009286	0.004036	0.004816	0.001884	-0.004036	-0.004816	-0.001884	
Prm24	0.001124	0.001535	0.001884	0.002280	-0.001535	-0.001884	-0.002280	
Prm30	-0.001509	-0.007315	-0.004036	-0.001535	0.01457	0.008036	0.003052	
Prm31	-0.001859	-0.004036	-0.004816	-0.001884	0.008036	0.009591	0.003749	
Prm32	-0.002251	-0.001535	-0.001884	-0.002280	0.003052	0.003749	0.004535	

Covariance Matrix (Empirical)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.005960	-0.005960	-0.005960	0.005960	-0.002205	-0.001844	-0.001106	0.002205	0.001844	
Prm2	-0.005960	0.01166	0.005960	-0.01166	0.002205	0.001844	0.001106	-0.004274	-0.003222	
Prm4	-0.005960	0.005960	0.01252	-0.01252	0.002205	0.001844	0.001106	-0.002205	-0.001844	
Prm6	0.005960	-0.01166	-0.01252	0.02244	-0.002205	-0.001844	-0.001106	0.004274	0.003222	
Prm10	-0.002205	0.002205	0.002205	-0.002205	0.003709	0.002450	0.001137	-0.003709	-0.002450	
Prm11	-0.001844	0.001844	0.001844	-0.001844	0.002450	0.002849	0.001473	-0.002450	-0.002849	
Prm12	-0.001106	0.001106	0.001106	-0.001106	0.001137	0.001473	0.001843	-0.001137	-0.001473	
Prm14	0.002205	-0.004274	-0.002205	0.004274	-0.003709	-0.002450	-0.001137	0.007898	0.004736	
Prm15	0.001844	-0.003222	-0.001844	0.003222	-0.002450	-0.002849	-0.001473	0.004736	0.005166	
Prm16	0.001106	-0.001934	-0.001106	0.001934	-0.001137	-0.001473	-0.001843	0.002090	0.002469	
Prm22	0.002205	-0.002205	-0.004933	0.004933	-0.003709	-0.002450	-0.001137	0.003709	0.002450	
Prm23	0.001844	-0.001844	-0.003465	0.003465	-0.002450	-0.002849	-0.001473	0.002450	0.002849	
Prm24	0.001106	-0.001106	-0.001749	0.001749	-0.001137	-0.001473	-0.001843	0.001137	0.001473	
Prm30	-0.002205	0.004274	0.004933	-0.008141	0.003709	0.002450	0.001137	-0.007898	-0.004736	
Prm31	-0.001844	0.003222	0.003465	-0.005572	0.002450	0.002849	0.001473	-0.004736	-0.005166	
Prm32	-0.001106	0.001934	0.001749	-0.002964	0.001137	0.001473	0.001843	-0.002090	-0.002469	

Covariance Matrix (Empirical)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.001106	0.002205	0.001844	0.001106	-0.002205	-0.001844	-0.001106	
Prm2	-0.001934	-0.002205	-0.001844	-0.001106	0.004274	0.003222	0.001934	
Prm4	-0.001106	-0.004933	-0.003465	-0.001749	0.004933	0.003465	0.001749	
Prm6	0.001934	0.004933	0.003465	0.001749	-0.008141	-0.005572	-0.002964	
Prm10	-0.001137	-0.003709	-0.002450	-0.001137	0.003709	0.002450	0.001137	
Prm11	-0.001473	-0.002450	-0.002849	-0.001473	0.002450	0.002849	0.001473	
Prm12	-0.001843	-0.001137	-0.001473	-0.001843	0.001137	0.001473	0.001843	
Prm14	0.002090	0.003709	0.002450	0.001137	-0.007898	-0.004736	-0.002090	
Prm15	0.002469	0.002450	0.002849	0.001473	-0.004736	-0.005166	-0.002469	
Prm16	0.003281	0.001137	0.001473	0.001843	-0.002090	-0.002469	-0.003281	
Prm22	0.001137	0.008613	0.004900	0.002004	-0.008613	-0.004900	-0.002004	
Prm23	0.001473	0.004900	0.005691	0.002649	-0.004900	-0.005691	-0.002649	
Prm24	0.001843	0.002004	0.002649	0.003096	-0.002004	-0.002649	-0.003096	
Prm30	-0.002090	-0.008613	-0.004900	-0.002004	0.01574	0.008642	0.003710	
Prm31	-0.002469	-0.004900	-0.005691	-0.002649	0.008642	0.009617	0.004376	
Prm32	-0.003281	-0.002004	-0.002649	-0.003096	0.003710	0.004376	0.005394	

Algorithm converged.	

Working Correlation Matrix	
	Col1	Col2	Col3	Col4	
Row1	1.0000	0.8173	0.7082	0.6745	
Row2	0.8173	1.0000	0.8521	0.7870	
Row3	0.7082	0.8521	1.0000	0.9003	
Row4	0.6745	0.7870	0.9003	1.0000	

GEE Fit Criteria	
QIC	-154124.0076	
QICu	-154123.3190	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4527	0.0772	-1.6041	-1.3014	-18.82	<.0001	
NALTREXONE	0			0.0391	0.1080	-0.1726	0.2507	0.36	0.7175	
NALTREXONE	1			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0			-0.0026	0.1119	-0.2218	0.2167	-0.02	0.9816	
THERAPY	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.2537	0.1498	-0.0399	0.5473	1.69	0.0903	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
month	1			-0.0039	0.0609	-0.1232	0.1155	-0.06	0.9492	
month	2			0.0670	0.0534	-0.0376	0.1716	1.25	0.2095	
month	3			0.0174	0.0429	-0.0668	0.1015	0.41	0.6854	
month	4			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		-0.1732	0.0889	-0.3474	0.0009	-1.95	0.0513	
NALTREXONE*month	0	2		-0.0910	0.0719	-0.2318	0.0499	-1.27	0.2057	
NALTREXONE*month	0	3		-0.0483	0.0573	-0.1606	0.0640	-0.84	0.3991	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		-0.2343	0.0928	-0.4162	-0.0524	-2.52	0.0116	
THERAPY*month	0	2		-0.1000	0.0754	-0.2479	0.0479	-1.33	0.1850	
THERAPY*month	0	3		-0.0325	0.0556	-0.1416	0.0765	-0.58	0.5589	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.1087	0.1255	-0.1372	0.3546	0.87	0.3864	
NALTRE*THERAPY*month	0	0	2	0.0309	0.0981	-0.1613	0.2231	0.31	0.7530	
NALTRE*THERAPY*month	0	0	3	0.0247	0.0734	-0.1193	0.1686	0.34	0.7370	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.59	0.1074	
THERAPY	1	0.62	0.4305	
NALTREXONE*THERAPY	1	4.78	0.0288	
month	3	50.05	<.0001	
NALTREXONE*month	3	3.66	0.3009	
THERAPY*month	3	8.45	0.0375	
NALTRE*THERAPY*month	3	0.96	0.8108	

month Least Squares Means	
month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	Lower Mean	Upper Mean	Exponentiated	
1	-1.5515	0.03700	-41.94	<.0001	0.05	-1.6241	-1.4790	0.2119	0.007841	0.1971	0.2279	0.2119	
2	-1.3919	0.03616	-38.50	<.0001	0.05	-1.4627	-1.3210	0.2486	0.008989	0.2316	0.2669	0.2486	
3	-1.3879	0.03700	-37.51	<.0001	0.05	-1.4604	-1.3154	0.2496	0.009236	0.2321	0.2684	0.2496	
4	-1.3711	0.03745	-36.61	<.0001	0.05	-1.4445	-1.2977	0.2538	0.009507	0.2359	0.2732	0.2538	

month Least Squares Means	
month	Exponentiated Lower	Exponentiated Upper	
1	0.1971	0.2279	
2	0.2316	0.2669	
3	0.2321	0.2684	
4	0.2359	0.2732	

Differences of month Least Squares Means	
month	_month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Exponentiated	
1	2	-0.1597	0.02246	-7.11	<.0001	0.05	-0.2037	-0.1157	0.8524	
1	3	-0.1636	0.02928	-5.59	<.0001	0.05	-0.2210	-0.1062	0.8491	
1	4	-0.1805	0.03137	-5.75	<.0001	0.05	-0.2419	-0.1190	0.8349	
2	3	-0.00394	0.01978	-0.20	0.8419	0.05	-0.04271	0.03482	0.9961	
2	4	-0.02079	0.02452	-0.85	0.3965	0.05	-0.06884	0.02727	0.9794	
3	4	-0.01684	0.01836	-0.92	0.3590	0.05	-0.05283	0.01915	0.9833	

Differences of month Least Squares Means	
month	_month	Exponentiated Lower	Exponentiated Upper	
1	2	0.8157	0.8908	
1	3	0.8017	0.8992	
1	4	0.7851	0.8878	
2	3	0.9582	1.0354	
2	4	0.9335	1.0276	
3	4	0.9485	1.0193	

NALTREXONE	THERAPY	month	N Obs	Variable	Label	N	Mean	Std Dev	Minimum	Maximum	
0	0	1	305	ndr
predicted	
Predicted Value	304
304	6.3782895
6.4107045	7.7824158
0.4322939	0
1.3860983	28.0000000
6.4684586	
		2	305	ndr
predicted	
Predicted Value	298
298	7.9697987
7.9051706	9.1652851
0.6087599	0
1.1395530	28.0000000
7.9768707	
		3	305	ndr
predicted	
Predicted Value	291
291	8.3092784
8.3265078	9.5100972
0.7488572	0
0.9024260	28.0000000
8.4226425	
		4	305	ndr
predicted	
Predicted Value	285
285	8.7543860
8.7103898	9.8024154
0.4355855	0
2.1888434	28.0000000
8.7553736	
	1	1	307	ndr
predicted	
Predicted Value	305
305	5.6065574
5.6151810	7.5150697
0.5017423	0
1.4263428	28.0000000
5.7053713	
		2	307	ndr
predicted	
Predicted Value	294
294	6.5714286
6.6027143	8.3469968
0.4660830	0
0.9499379	28.0000000
6.6495650	
		3	307	ndr
predicted	
Predicted Value	291
291	6.5463918
6.5866862	8.4396690
0.1803000	0
4.4810862	28.0000000
6.6037060	
		4	307	ndr
predicted	
Predicted Value	289
289	6.7577855
6.7755732	8.8676701
0.2909013	0
3.8919566	28.0000000
6.8109240	
1	0	1	302	ndr
predicted	
Predicted Value	302
302	5.0463576
5.0542519	6.8368143
0.5623722	0
0.1838795	28.0000000
5.1486272	
		2	302	ndr
predicted	
Predicted Value	293
293	6.0716724
6.2184139	8.3003332
0.6236591	0
0.6772377	28.0000000
6.3208856	
		3	302	ndr
predicted	
Predicted Value	286
286	6.2377622
6.4037286	8.8229828
0.3043123	0
2.5280625	28.0000000
6.4350682	
		4	302	ndr
predicted	
Predicted Value	283
283	6.2756184
6.4630319	8.9530893
0.5857855	0
0.4666509	28.0000000
6.5331119	
	1	1	312	ndr
predicted	
Predicted Value	309
309	6.4142395
6.4062188	8.3029054
0.6740592	0
1.3981318	28.0000000
6.5246150	
		2	312	ndr
predicted	
Predicted Value	297
297	6.9696970
6.9809729	8.8146698
0.3213490	0
1.5007955	28.0000000
7.0037122	
		3	312	ndr
predicted	
Predicted Value	295
295	6.5661017
6.5713107	8.6834860
0.7152283	0
0.2380325	28.0000000
6.6649099	
		4	312	ndr
predicted	
Predicted Value	290
290	6.5482759
6.5435236	8.8164333
0.0642177	0
5.6142658	28.0000000
6.5499768	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1383 1382 1380 1379 1378 1377 1376 1375 1374 1373 1371 1370 1369 1368 1367 1366 1365 1364 1363 1361 1360 1359 1358 1357 1355 1354 1353 1352 1351 1350 1349 1347 1346 1345 1344 1343 1342 1341 1339 1338 1337 1336 1335 1334 1333 1332 1331 1329 1328 1327 ...	
NALTREXONE	2	1 0	
THERAPY	2	1 0	
month	4	4 3 2 1	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	month	
Prm1	Intercept				
Prm2	NALTREXONE	1			
Prm3	NALTREXONE	0			
Prm4	THERAPY		1		
Prm5	THERAPY		0		
Prm6	NALTREXONE*THERAPY	1	1		
Prm7	NALTREXONE*THERAPY	1	0		
Prm8	NALTREXONE*THERAPY	0	1		
Prm9	NALTREXONE*THERAPY	0	0		
Prm10	month			4	
Prm11	month			3	
Prm12	month			2	
Prm13	month			1	
Prm14	NALTREXONE*month	1		4	
Prm15	NALTREXONE*month	1		3	
Prm16	NALTREXONE*month	1		2	
Prm17	NALTREXONE*month	1		1	
Prm18	NALTREXONE*month	0		4	
Prm19	NALTREXONE*month	0		3	
Prm20	NALTREXONE*month	0		2	
Prm21	NALTREXONE*month	0		1	
Prm22	THERAPY*month		1	4	
Prm23	THERAPY*month		1	3	
Prm24	THERAPY*month		1	2	
Prm25	THERAPY*month		1	1	
Prm26	THERAPY*month		0	4	
Prm27	THERAPY*month		0	3	
Prm28	THERAPY*month		0	2	
Prm29	THERAPY*month		0	1	
Prm30	NALTRE*THERAPY*month	1	1	4	
Prm31	NALTRE*THERAPY*month	1	1	3	
Prm32	NALTRE*THERAPY*month	1	1	2	
Prm33	NALTRE*THERAPY*month	1	1	1	
Prm34	NALTRE*THERAPY*month	1	0	4	
Prm35	NALTRE*THERAPY*month	1	0	3	
Prm36	NALTRE*THERAPY*month	1	0	2	
Prm37	NALTRE*THERAPY*month	1	0	1	
Prm38	NALTRE*THERAPY*month	0	1	4	
Prm39	NALTRE*THERAPY*month	0	1	3	
Prm40	NALTRE*THERAPY*month	0	1	2	
Prm41	NALTRE*THERAPY*month	0	1	1	
Prm42	NALTRE*THERAPY*month	0	0	4	
Prm43	NALTRE*THERAPY*month	0	0	3	
Prm44	NALTRE*THERAPY*month	0	0	2	
Prm45	NALTRE*THERAPY*month	0	0	1	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Unstructured	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Covariance Matrix (Model-Based)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.005390	-0.005390	-0.005390	0.005390	-0.001775	-0.001592	-0.001005	0.001775	0.001592	
Prm2	-0.005390	0.01091	0.005390	-0.01091	0.001775	0.001592	0.001005	-0.003593	-0.003228	
Prm4	-0.005390	0.005390	0.01081	-0.01081	0.001775	0.001592	0.001005	-0.001775	-0.001592	
Prm6	0.005390	-0.01091	-0.01081	0.02163	-0.001775	-0.001592	-0.001005	0.003593	0.003228	
Prm10	-0.001775	0.001775	0.001775	-0.001775	0.003613	0.002850	0.001613	-0.003613	-0.002850	
Prm11	-0.001592	0.001592	0.001592	-0.001592	0.002850	0.003216	0.001784	-0.002850	-0.003216	
Prm12	-0.001005	0.001005	0.001005	-0.001005	0.001613	0.001784	0.001995	-0.001613	-0.001784	
Prm14	0.001775	-0.003593	-0.001775	0.003593	-0.003613	-0.002850	-0.001613	0.007325	0.005782	
Prm15	0.001592	-0.003228	-0.001592	0.003228	-0.002850	-0.003216	-0.001784	0.005782	0.006525	
Prm16	0.001005	-0.002039	-0.001005	0.002039	-0.001613	-0.001784	-0.001995	0.003275	0.003622	
Prm22	0.001775	-0.001775	-0.003556	0.003556	-0.003613	-0.002850	-0.001613	0.003613	0.002850	
Prm23	0.001592	-0.001592	-0.003188	0.003188	-0.002850	-0.003216	-0.001784	0.002850	0.003216	
Prm24	0.001005	-0.001005	-0.002013	0.002013	-0.001613	-0.001784	-0.001995	0.001613	0.001784	
Prm30	-0.001775	0.003593	0.003556	-0.007093	0.003613	0.002850	0.001613	-0.007325	-0.005782	
Prm31	-0.001592	0.003228	0.003188	-0.006365	0.002850	0.003216	0.001784	-0.005782	-0.006525	
Prm32	-0.001005	0.002039	0.002013	-0.004025	0.001613	0.001784	0.001995	-0.003275	-0.003622	

Covariance Matrix (Model-Based)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.001005	0.001775	0.001592	0.001005	-0.001775	-0.001592	-0.001005	
Prm2	-0.002039	-0.001775	-0.001592	-0.001005	0.003593	0.003228	0.002039	
Prm4	-0.001005	-0.003556	-0.003188	-0.002013	0.003556	0.003188	0.002013	
Prm6	0.002039	0.003556	0.003188	0.002013	-0.007093	-0.006365	-0.004025	
Prm10	-0.001613	-0.003613	-0.002850	-0.001613	0.003613	0.002850	0.001613	
Prm11	-0.001784	-0.002850	-0.003216	-0.001784	0.002850	0.003216	0.001784	
Prm12	-0.001995	-0.001613	-0.001784	-0.001995	0.001613	0.001784	0.001995	
Prm14	0.003275	0.003613	0.002850	0.001613	-0.007325	-0.005782	-0.003275	
Prm15	0.003622	0.002850	0.003216	0.001784	-0.005782	-0.006525	-0.003622	
Prm16	0.004050	0.001613	0.001784	0.001995	-0.003275	-0.003622	-0.004050	
Prm22	0.001613	0.007256	0.005739	0.003255	-0.007256	-0.005739	-0.003255	
Prm23	0.001784	0.005739	0.006477	0.003603	-0.005739	-0.006477	-0.003603	
Prm24	0.001995	0.003255	0.003603	0.004030	-0.003255	-0.003603	-0.004030	
Prm30	-0.003275	-0.007256	-0.005739	-0.003255	0.01457	0.01152	0.006534	
Prm31	-0.003622	-0.005739	-0.006477	-0.003603	0.01152	0.01300	0.007231	
Prm32	-0.004050	-0.003255	-0.003603	-0.004030	0.006534	0.007231	0.008088	

Covariance Matrix (Empirical)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm12	Prm14	Prm15	
Prm1	0.004889	-0.004889	-0.004889	0.004889	-0.001799	-0.001434	-0.001072	0.001799	0.001434	
Prm2	-0.004889	0.01089	0.004889	-0.01089	0.001799	0.001434	0.001072	-0.003975	-0.003386	
Prm4	-0.004889	0.004889	0.01064	-0.01064	0.001799	0.001434	0.001072	-0.001799	-0.001434	
Prm6	0.004889	-0.01089	-0.01064	0.02190	-0.001799	-0.001434	-0.001072	0.003975	0.003386	
Prm10	-0.001799	0.001799	0.001799	-0.001799	0.002939	0.002186	0.001483	-0.002939	-0.002186	
Prm11	-0.001434	0.001434	0.001434	-0.001434	0.002186	0.002295	0.001462	-0.002186	-0.002295	
Prm12	-0.001072	0.001072	0.001072	-0.001072	0.001483	0.001462	0.001635	-0.001483	-0.001462	
Prm14	0.001799	-0.003975	-0.001799	0.003975	-0.002939	-0.002186	-0.001483	0.007843	0.006222	
Prm15	0.001434	-0.003386	-0.001434	0.003386	-0.002186	-0.002295	-0.001462	0.006222	0.006715	
Prm16	0.001072	-0.002420	-0.001072	0.002420	-0.001483	-0.001462	-0.001635	0.003937	0.004224	
Prm22	0.001799	-0.001799	-0.003919	0.003919	-0.002939	-0.002186	-0.001483	0.002939	0.002186	
Prm23	0.001434	-0.001434	-0.003429	0.003429	-0.002186	-0.002295	-0.001462	0.002186	0.002295	
Prm24	0.001072	-0.001072	-0.002284	0.002284	-0.001483	-0.001462	-0.001635	0.001483	0.001462	
Prm30	-0.001799	0.003975	0.003919	-0.007599	0.002939	0.002186	0.001483	-0.007843	-0.006222	
Prm31	-0.001434	0.003386	0.003429	-0.006854	0.002186	0.002295	0.001462	-0.006222	-0.006715	
Prm32	-0.001072	0.002420	0.002284	-0.004530	0.001483	0.001462	0.001635	-0.003937	-0.004224	

Covariance Matrix (Empirical)	
	Prm16	Prm22	Prm23	Prm24	Prm30	Prm31	Prm32	
Prm1	0.001072	0.001799	0.001434	0.001072	-0.001799	-0.001434	-0.001072	
Prm2	-0.002420	-0.001799	-0.001434	-0.001072	0.003975	0.003386	0.002420	
Prm4	-0.001072	-0.003919	-0.003429	-0.002284	0.003919	0.003429	0.002284	
Prm6	0.002420	0.003919	0.003429	0.002284	-0.007599	-0.006854	-0.004530	
Prm10	-0.001483	-0.002939	-0.002186	-0.001483	0.002939	0.002186	0.001483	
Prm11	-0.001462	-0.002186	-0.002295	-0.001462	0.002186	0.002295	0.001462	
Prm12	-0.001635	-0.001483	-0.001462	-0.001635	0.001483	0.001462	0.001635	
Prm14	0.003937	0.002939	0.002186	0.001483	-0.007843	-0.006222	-0.003937	
Prm15	0.004224	0.002186	0.002295	0.001462	-0.006222	-0.006715	-0.004224	
Prm16	0.004482	0.001483	0.001462	0.001635	-0.003937	-0.004224	-0.004482	
Prm22	0.001483	0.007128	0.005422	0.003386	-0.007128	-0.005422	-0.003386	
Prm23	0.001462	0.005422	0.006015	0.003407	-0.005422	-0.006015	-0.003407	
Prm24	0.001635	0.003386	0.003407	0.003569	-0.003386	-0.003407	-0.003569	
Prm30	-0.003937	-0.007128	-0.005422	-0.003386	0.01574	0.01203	0.007099	
Prm31	-0.004224	-0.005422	-0.006015	-0.003407	0.01203	0.01371	0.007765	
Prm32	-0.004482	-0.003386	-0.003407	-0.003569	0.007099	0.007765	0.008074	

Algorithm converged.	

Working Correlation Matrix	
	Col1	Col2	Col3	Col4	
Row1	1.0000	0.8173	0.7082	0.6745	
Row2	0.8173	1.0000	0.8521	0.7870	
Row3	0.7082	0.8521	1.0000	0.9003	
Row4	0.6745	0.7870	0.9003	1.0000	

GEE Fit Criteria	
QIC	-154124.0076	
QICu	-154123.3190	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept				-1.4653	0.0699	-1.6023	-1.3282	-20.96	<.0001	
NALTREXONE	1			-0.2282	0.1044	-0.4328	-0.0236	-2.19	0.0288	
NALTREXONE	0			0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	1			-0.1255	0.1031	-0.3277	0.0766	-1.22	0.2236	
THERAPY	0			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1		0.3624	0.1480	0.0723	0.6524	2.45	0.0143	
NALTREXONE*THERAPY	1	0		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0		0.0000	0.0000	0.0000	0.0000	.	.	
month	4			0.3027	0.0542	0.1965	0.4090	5.58	<.0001	
month	3			0.2640	0.0479	0.1701	0.3579	5.51	<.0001	
month	2			0.2096	0.0404	0.1304	0.2889	5.18	<.0001	
month	1			0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	1	4		-0.0646	0.0886	-0.2381	0.1090	-0.73	0.4659	
NALTREXONE*month	1	3		-0.0410	0.0819	-0.2016	0.1197	-0.50	0.6172	
NALTREXONE*month	1	2		-0.0045	0.0669	-0.1357	0.1267	-0.07	0.9467	
NALTREXONE*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	3		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	2		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*month	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	1	4		-0.1256	0.0844	-0.2911	0.0399	-1.49	0.1368	
THERAPY*month	1	3		-0.1178	0.0776	-0.2698	0.0342	-1.52	0.1289	
THERAPY*month	1	2		-0.0565	0.0597	-0.1736	0.0606	-0.95	0.3446	
THERAPY*month	1	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	4		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	3		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	2		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY*month	0	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	1	4	-0.1087	0.1255	-0.3546	0.1372	-0.87	0.3864	
NALTRE*THERAPY*month	1	1	3	-0.0840	0.1171	-0.3135	0.1455	-0.72	0.4732	
NALTRE*THERAPY*month	1	1	2	-0.0778	0.0899	-0.2539	0.0983	-0.87	0.3865	
NALTRE*THERAPY*month	1	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	1	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	4	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	3	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	2	0.0000	0.0000	0.0000	0.0000	.	.	
NALTRE*THERAPY*month	0	0	1	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	2.59	0.1074	
THERAPY	1	0.62	0.4305	
NALTREXONE*THERAPY	1	4.78	0.0288	
month	3	50.05	<.0001	
NALTREXONE*month	3	3.66	0.3009	
THERAPY*month	3	8.45	0.0375	
NALTRE*THERAPY*month	3	0.96	0.8108	

THERAPY*month Least Squares Means	
THERAPY	month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	Lower Mean	Upper Mean	
1	4	-1.4332	0.05399	-26.55	<.0001	0.05	-1.5390	-1.3274	0.2385	0.01288	0.2146	0.2652	
1	3	-1.4400	0.05261	-27.37	<.0001	0.05	-1.5431	-1.3368	0.2369	0.01247	0.2137	0.2627	
1	2	-1.4117	0.05094	-27.71	<.0001	0.05	-1.5115	-1.3119	0.2437	0.01242	0.2206	0.2693	
1	1	-1.5237	0.05246	-29.05	<.0001	0.05	-1.6265	-1.4209	0.2179	0.01143	0.1966	0.2415	
0	4	-1.3089	0.05193	-25.21	<.0001	0.05	-1.4107	-1.2072	0.2701	0.01403	0.2440	0.2990	
0	3	-1.3359	0.05205	-25.66	<.0001	0.05	-1.4379	-1.2338	0.2629	0.01369	0.2374	0.2912	
0	2	-1.3720	0.05132	-26.73	<.0001	0.05	-1.4726	-1.2714	0.2536	0.01302	0.2293	0.2804	
0	1	-1.5794	0.05219	-30.26	<.0001	0.05	-1.6817	-1.4771	0.2061	0.01076	0.1861	0.2283	

THERAPY*month Least Squares Means	
THERAPY	month	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	4	0.2385	0.2146	0.2652	
1	3	0.2369	0.2137	0.2627	
1	2	0.2437	0.2206	0.2693	
1	1	0.2179	0.1966	0.2415	
0	4	0.2701	0.2440	0.2990	
0	3	0.2629	0.2374	0.2912	
0	2	0.2536	0.2293	0.2804	
0	1	0.2061	0.1861	0.2283	

Differences of THERAPY*month Least Squares Means	
THERAPY	month	_THERAPY	_month	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	
1	4	1	3	0.006751	0.02864	0.24	0.8136	0.05	-0.04938	0.06288	
1	4	1	2	-0.02150	0.03594	-0.60	0.5497	0.05	-0.09194	0.04894	
1	4	1	1	0.09050	0.04444	2.04	0.0417	0.05	0.003408	0.1776	
1	4	0	4	-0.1243	0.07490	-1.66	0.0971	0.05	-0.2711	0.02253	
1	4	0	3	-0.09735	0.07499	-1.30	0.1942	0.05	-0.2443	0.04963	
1	4	0	2	-0.06121	0.07449	-0.82	0.4112	0.05	-0.2072	0.08478	
1	4	0	1	0.1462	0.07508	1.95	0.0516	0.05	-0.00100	0.2933	
1	3	1	2	-0.02825	0.02962	-0.95	0.3402	0.05	-0.08631	0.02980	
1	3	1	1	0.08375	0.04183	2.00	0.0453	0.05	0.001762	0.1657	
1	3	0	4	-0.1310	0.07392	-1.77	0.0763	0.05	-0.2759	0.01385	
1	3	0	3	-0.1041	0.07401	-1.41	0.1595	0.05	-0.2492	0.04095	
1	3	0	2	-0.06796	0.07350	-0.92	0.3551	0.05	-0.2120	0.07609	
1	3	0	1	0.1394	0.07410	1.88	0.0599	0.05	-0.00583	0.2846	
1	2	1	1	0.1120	0.02997	3.74	0.0002	0.05	0.05327	0.1707	
1	2	0	4	-0.1028	0.07274	-1.41	0.1577	0.05	-0.2453	0.03979	
1	2	0	3	-0.07585	0.07283	-1.04	0.2977	0.05	-0.2186	0.06690	
1	2	0	2	-0.03971	0.07231	-0.55	0.5829	0.05	-0.1814	0.1020	
1	2	0	1	0.1677	0.07293	2.30	0.0215	0.05	0.02473	0.3106	
1	1	0	4	-0.2148	0.07381	-2.91	0.0036	0.05	-0.3595	-0.07011	
1	1	0	3	-0.1878	0.07390	-2.54	0.0110	0.05	-0.3327	-0.04301	
1	1	0	2	-0.1517	0.07339	-2.07	0.0387	0.05	-0.2955	-0.00787	
1	1	0	1	0.05566	0.07400	0.75	0.4519	0.05	-0.08937	0.2007	
0	4	0	3	0.02693	0.02299	1.17	0.2413	0.05	-0.01812	0.07199	
0	4	0	2	0.06307	0.03336	1.89	0.0586	0.05	-0.00230	0.1284	
0	4	0	1	0.2704	0.04428	6.11	<.0001	0.05	0.1837	0.3572	
0	3	0	2	0.03614	0.02622	1.38	0.1680	0.05	-0.01524	0.08752	
0	3	0	1	0.2435	0.04097	5.94	<.0001	0.05	0.1632	0.3238	
0	2	0	1	0.2074	0.03347	6.20	<.0001	0.05	0.1418	0.2730	

Differences of THERAPY*month Least Squares Means	
THERAPY	month	_THERAPY	_month	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	4	1	3	1.0068	0.9518	1.0649	
1	4	1	2	0.9787	0.9122	1.0502	
1	4	1	1	1.0947	1.0034	1.1943	
1	4	0	4	0.8831	0.7625	1.0228	
1	4	0	3	0.9072	0.7832	1.0509	
1	4	0	2	0.9406	0.8129	1.0885	
1	4	0	1	1.1574	0.9990	1.3409	
1	3	1	2	0.9721	0.9173	1.0303	
1	3	1	1	1.0874	1.0018	1.1803	
1	3	0	4	0.8772	0.7589	1.0139	
1	3	0	3	0.9011	0.7795	1.0418	
1	3	0	2	0.9343	0.8090	1.0791	
1	3	0	1	1.1496	0.9942	1.3293	
1	2	1	1	1.1185	1.0547	1.1862	
1	2	0	4	0.9023	0.7824	1.0406	
1	2	0	3	0.9270	0.8036	1.0692	
1	2	0	2	0.9611	0.8341	1.1074	
1	2	0	1	1.1825	1.0250	1.3642	
1	1	0	4	0.8067	0.6981	0.9323	
1	1	0	3	0.8287	0.7170	0.9579	
1	1	0	2	0.8592	0.7441	0.9922	
1	1	0	1	1.0572	0.9145	1.2222	
0	4	0	3	1.0273	0.9820	1.0746	
0	4	0	2	1.0651	0.9977	1.1371	
0	4	0	1	1.3105	1.2016	1.4294	
0	3	0	2	1.0368	0.9849	1.0915	
0	3	0	1	1.2757	1.1773	1.3824	
0	2	0	1	1.2304	1.1523	1.3139	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	Lower	Upper	Mean	Standard Error of Mean	
1	1	-1.4326	0.06738	-21.26	<.0001	0.05	-1.5647	-1.3006	0.2387	0.01608	
1	0	-1.5269	0.07200	-21.21	<.0001	0.05	-1.6680	-1.3858	0.2172	0.01564	
0	1	-1.4717	0.06772	-21.73	<.0001	0.05	-1.6044	-1.3390	0.2295	0.01554	
0	0	-1.2712	0.06170	-20.60	<.0001	0.05	-1.3921	-1.1503	0.2805	0.01731	

NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	Lower Mean	Upper Mean	Exponentiated	Exponentiated Lower	Exponentiated Upper	
1	1	0.2092	0.2724	0.2387	0.2092	0.2724	
1	0	0.1886	0.2501	0.2172	0.1886	0.2501	
0	1	0.2010	0.2621	0.2295	0.2010	0.2621	
0	0	0.2485	0.3166	0.2805	0.2485	0.3166	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Estimate	Standard Error	z Value	Pr > |z|	Alpha	
1	1	1	0	0.09428	0.09861	0.96	0.3391	0.05	
1	1	0	1	0.03906	0.09553	0.41	0.6827	0.05	
1	1	0	0	-0.1614	0.09136	-1.77	0.0772	0.05	
1	0	0	1	-0.05522	0.09884	-0.56	0.5764	0.05	
1	0	0	0	-0.2557	0.09482	-2.70	0.0070	0.05	
0	1	0	0	-0.2005	0.09161	-2.19	0.0286	0.05	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Lower	Upper	Exponentiated	
1	1	1	0	-0.09900	0.2876	1.0989	
1	1	0	1	-0.1482	0.2263	1.0398	
1	1	0	0	-0.3405	0.01764	0.8509	
1	0	0	1	-0.2489	0.1385	0.9463	
1	0	0	0	-0.4416	-0.06987	0.7744	
0	1	0	0	-0.3800	-0.02093	0.8183	

Differences of NALTREXONE*THERAPY Least Squares Means	
NALTREXONE	THERAPY	_NALTREXONE	_THERAPY	Exponentiated Lower	Exponentiated Upper	
1	1	1	0	0.9057	1.3332	
1	1	0	1	0.8623	1.2539	
1	1	0	0	0.7114	1.0178	
1	0	0	1	0.7796	1.1486	
1	0	0	0	0.6430	0.9325	
0	1	0	0	0.6838	0.9793	

Model Information	
Data Set	WORK.LONG	
Response Variable	ndr	
Response Distribution	Negative Binomial	
Link Function	Log	
Variance Function	Default	
Offset Variable	offset	
Variance Matrix Blocked By	ID_COMB	
Estimation Technique	Maximum Likelihood	
Likelihood Approximation	Gauss-Hermite Quadrature	
Degrees of Freedom Method	Containment	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 100 101 102 103 104 105 106 108 109 110 111 112 113 114 115 117 118 119 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 139 140 141 142 143 144 145 146 147 148 149 150 151 152 155 156 157 158 159 160 161 163 164 165 166 167 168 169 170 171 173 174 175 176 177 178 179 180 181 182 183 185 186 187 189 190 191 192 193 194 195 196 197 198 199 200 201 202 204 205 206 207 208 209 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 231 232 233 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 253 255 256 257 258 259 260 261 262 263 265 266 267 268 269 270 271 273 274 275 276 277 278 279 280 281 282 283 284 285 287 288 289 290 291 292 293 295 296 297 299 300 301 302 303 304 306 307 308 309 310 311 313 314 315 316 317 318 319 320 321 322 323 324 325 327 328 329 330 331 332 333 334 335 336 337 338 340 341 342 343 344 345 346 347 349 350 351 352 353 354 356 357 358 359 360 361 363 364 365 366 367 368 369 370 371 372 374 375 376 378 379 380 381 382 383 384 385 386 387 388 389 390 392 393 394 395 396 397 398 400 401 402 404 405 406 407 408 409 410 411 412 413 414 415 416 417 419 420 421 422 423 424 426 427 428 429 430 431 432 433 434 435 437 438 439 440 442 443 444 445 446 447 448 449 450 451 452 453 455 456 457 458 459 460 462 463 464 465 466 467 468 469 470 471 472 474 476 477 478 479 480 481 482 483 484 485 486 487 489 490 491 492 493 494 496 497 498 499 500 501 502 504 505 506 507 508 509 510 511 512 515 516 517 518 519 520 521 522 523 525 526 527 528 529 530 531 532 533 534 535 536 537 538 540 542 543 544 545 546 547 548 550 551 552 553 554 555 556 557 558 559 560 561 563 564 565 567 568 569 570 571 572 573 574 575 577 578 579 580 581 583 584 585 586 587 588 590 591 592 593 594 595 596 598 599 600 601 602 604 605 606 607 608 609 610 611 612 613 614 615 617 618 619 620 621 622 624 625 626 628 629 630 631 632 633 634 635 636 637 638 639 640 642 643 645 646 647 648 649 650 651 652 653 654 655 656 657 658 660 661 662 664 665 666 667 668 669 670 671 672 674 675 676 677 679 680 681 682 683 684 685 686 687 688 689 691 692 693 694 695 696 697 698 700 701 702 703 704 705 706 708 709 710 711 713 714 715 716 717 718 719 720 721 722 723 724 725 726 728 729 730 731 732 733 734 735 737 738 739 740 741 742 743 744 745 747 749 750 751 752 753 754 755 756 757 758 759 760 761 762 763 765 766 767 768 769 770 771 773 774 775 776 777 778 779 780 782 783 784 785 786 788 789 790 791 792 793 794 795 796 797 798 799 800 802 803 804 806 807 808 809 810 811 812 813 814 815 817 818 819 820 821 822 823 824 825 826 827 828 830 831 832 834 835 836 837 838 839 840 841 842 844 845 846 847 848 849 850 851 852 854 855 856 857 859 860 861 862 863 864 865 866 868 869 870 871 872 873 874 875 876 877 878 879 881 882 883 884 886 887 888 889 890 891 892 894 895 896 897 898 899 901 902 903 904 905 906 907 908 909 910 911 913 914 915 917 918 919 920 921 922 923 924 926 927 928 929 930 931 932 933 934 935 937 938 939 940 941 942 943 944 945 947 948 949 950 951 953 954 955 956 957 958 959 960 962 963 964 965 966 967 968 969 970 971 972 974 975 976 978 979 980 981 982 983 984 986 987 988 989 990 991 992 994 995 996 997 998 999 1000 1001 1002 1003 1005 1006 1007 1008 1009 1011 1012 1014 1015 1016 1017 1019 1020 1021 1022 1023 1024 1025 1026 1028 1029 1030 1031 1032 1033 1034 1035 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1050 1051 1052 1053 1054 1056 1057 1058 1059 1060 1062 1063 1064 1065 1066 1067 1068 1069 1070 1071 1072 1074 1075 1076 1077 1078 1080 1081 1082 1083 1084 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 1101 1103 1104 1105 1106 1107 1108 1109 1110 1112 1113 1114 1115 1116 1117 1118 1119 1120 1122 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 1136 1137 1138 1139 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1154 1155 1156 1157 1158 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 1171 1172 1173 1174 1175 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 1201 1203 1204 1205 1206 1207 1208 1209 1211 1212 1213 1214 1215 1216 1218 1219 1220 1221 1222 1223 1224 1225 1227 1228 1229 1231 1232 1233 1234 1235 1236 1237 1238 1239 1240 1241 1242 1244 1245 1246 1247 1248 1249 1251 1252 1253 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1268 1269 1270 1272 1273 1274 1275 1276 1277 1278 1279 1280 1281 1282 1284 1285 1286 1287 1288 1289 1290 1291 1292 1294 1295 1296 1297 1298 1299 1300 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1313 1314 1315 1316 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1331 1332 1333 1334 1335 1336 1337 1338 1339 1341 1342 1343 1344 1345 1346 1347 1349 1350 1351 1352 1353 1354 1355 1357 1358 1359 1360 1361 1363 1364 1365 1366 1367 1368 1369 1370 1371 1373 1374 1375 1376 1377 1378 1379 1380 1382 1383	
NALTREXONE	2	0 1	
THERAPY	2	0 1	

Number of Observations Read	4904	
Number of Observations Used	4712	

Dimensions	
G-side Cov. Parameters	1	
R-side Cov. Parameters	1	
Columns in X	18	
Columns in Z per Subject	1	
Subjects (Blocks in V)	1226	
Max Obs per Subject	4	

Optimization Information	
Optimization Technique	Dual Quasi-Newton	
Parameters in Optimization	10	
Lower Boundaries	2	
Upper Boundaries	0	
Fixed Effects	Not Profiled	
Starting From	GLM estimates	
Quadrature Points	5	

Iteration History	
Iteration	Restarts	Evaluations	Objective
Function	Change	Max
Gradient	
0	0	4	24272.941777	.	3510.32	
1	0	4	23999.201092	273.74068494	723.3482	
2	0	3	23680.521666	318.67942657	793.8644	
3	0	3	23451.610316	228.91134931	1026.551	
4	0	5	23422.116365	29.49395120	1323.302	
5	0	2	23362.171995	59.94437034	991.4714	
6	0	3	23352.62121	9.55078481	983.0452	
7	0	4	23269.464144	83.15706548	330.5458	
8	0	3	23252.047989	17.41615514	151.5459	
9	0	2	23237.573577	14.47441239	93.39328	
10	0	2	23227.273491	10.30008619	131.959	
11	0	3	23222.172003	5.10148758	23.66114	
12	0	3	23221.697839	0.47416408	6.596562	
13	0	3	23221.683246	0.01459343	0.910874	
14	0	3	23221.683152	0.00009332	0.118515	

Convergence criterion (GCONV=1E-8) satisfied.	

Fit Statistics	
-2 Log Likelihood	23221.68	
AIC  (smaller is better)	23241.68	
AICC (smaller is better)	23241.73	
BIC  (smaller is better)	23292.80	
CAIC (smaller is better)	23302.80	
HQIC (smaller is better)	23260.92	

Fit Statistics for Conditional Distribution	
-2 log L(ndr | r. effects)	18883.27	
Pearson Chi-Square	2947.56	
Pearson Chi-Square / DF	0.63	

Covariance Parameter Estimates	
Cov Parm	Subject	Estimate	Standard Error	
UN(1,1)	ID_COMB	3.8622	0.2140	
Scale		0.2812	0.01516	

Solutions for Fixed Effects	
Effect	NALTREXONE	THERAPY	Estimate	Standard Error	DF	t Value	Pr > |t|	
Intercept			-2.5618	0.1311	1216	-19.53	<.0001	
NALTREXONE	0		-0.1048	0.1845	3488	-0.57	0.5699	
NALTREXONE	1		0	.	.	.	.	
THERAPY		0	-0.3122	0.1864	3488	-1.67	0.0941	
THERAPY		1	0	.	.	.	.	
NALTREXONE*THERAPY	0	0	0.3949	0.2620	3488	1.51	0.1318	
NALTREXONE*THERAPY	0	1	0	.	.	.	.	
NALTREXONE*THERAPY	1	0	0	.	.	.	.	
NALTREXONE*THERAPY	1	1	0	.	.	.	.	
month			-0.02110	0.02158	3488	-0.98	0.3282	
month*NALTREXONE	0		0.05443	0.03050	3488	1.78	0.0744	
month*NALTREXONE	1		0	.	.	.	.	
month*THERAPY		0	0.06503	0.03135	3488	2.07	0.0381	
month*THERAPY		1	0	.	.	.	.	
month*NALTRE*THERAPY	0	0	-0.00429	0.04328	3488	-0.10	0.9211	
month*NALTRE*THERAPY	0	1	0	.	.	.	.	
month*NALTRE*THERAPY	1	0	0	.	.	.	.	
month*NALTRE*THERAPY	1	1	0	.	.	.	.	

Type III Tests of Fixed Effects	
Effect	Num DF	Den DF	F Value	Pr > F	
NALTREXONE	1	3488	0.50	0.4796	
THERAPY	1	3488	0.77	0.3812	
NALTREXONE*THERAPY	1	3488	2.27	0.1318	
month	1	3488	12.02	0.0005	
month*NALTREXONE	1	3488	5.84	0.0157	
month*THERAPY	1	3488	8.44	0.0037	
month*NALTRE*THERAPY	1	3488	0.01	0.9211	

Estimates	
Label	Estimate	Standard Error	DF	t Value	Pr > |t|	Alpha	Lower	Upper	Exponentiated
Estimate	
Slope for no CBI group	0.06899	0.01536	3488	4.49	<.0001	0.05	0.03888	0.09911	1.0714	
Slope for CBI group	0.006109	0.01526	3488	0.40	0.6889	0.05	-0.02381	0.03602	1.0061	
Slope for placebo group	0.06369	0.01492	3488	4.27	<.0001	0.05	0.03444	0.09295	1.0658	
Slope for naltrexone group	0.01141	0.01569	3488	0.73	0.4670	0.05	-0.01934	0.04216	1.0115	
Difference in slopes: no CBI vs CBI	0.06289	0.02164	3488	2.91	0.0037	0.05	0.02046	0.1053	1.0649	
Difference in slope:placebo vs naltrexone	0.05228	0.02164	3488	2.42	0.0157	0.05	0.009854	0.09471	1.0537	

Estimates	
Label	Exponentiated
Lower	Exponentiated
Upper	
Slope for no CBI group	1.0396	1.1042	
Slope for CBI group	0.9765	1.0367	
Slope for placebo group	1.0350	1.0974	
Slope for naltrexone group	0.9808	1.0431	
Difference in slopes: no CBI vs CBI	1.0207	1.1111	
Difference in slope:placebo vs naltrexone	1.0099	1.0993	

Model Information	
Data Set	WORK.LONG	
Response Variable	ndr	
Response Distribution	Negative Binomial	
Link Function	Log	
Variance Function	Default	
Offset Variable	offset	
Variance Matrix Blocked By	ID_COMB	
Estimation Technique	Maximum Likelihood	
Likelihood Approximation	Gauss-Hermite Quadrature	
Degrees of Freedom Method	Containment	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 100 101 102 103 104 105 106 108 109 110 111 112 113 114 115 117 118 119 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 139 140 141 142 143 144 145 146 147 148 149 150 151 152 155 156 157 158 159 160 161 163 164 165 166 167 168 169 170 171 173 174 175 176 177 178 179 180 181 182 183 185 186 187 189 190 191 192 193 194 195 196 197 198 199 200 201 202 204 205 206 207 208 209 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 231 232 233 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 253 255 256 257 258 259 260 261 262 263 265 266 267 268 269 270 271 273 274 275 276 277 278 279 280 281 282 283 284 285 287 288 289 290 291 292 293 295 296 297 299 300 301 302 303 304 306 307 308 309 310 311 313 314 315 316 317 318 319 320 321 322 323 324 325 327 328 329 330 331 332 333 334 335 336 337 338 340 341 342 343 344 345 346 347 349 350 351 352 353 354 356 357 358 359 360 361 363 364 365 366 367 368 369 370 371 372 374 375 376 378 379 380 381 382 383 384 385 386 387 388 389 390 392 393 394 395 396 397 398 400 401 402 404 405 406 407 408 409 410 411 412 413 414 415 416 417 419 420 421 422 423 424 426 427 428 429 430 431 432 433 434 435 437 438 439 440 442 443 444 445 446 447 448 449 450 451 452 453 455 456 457 458 459 460 462 463 464 465 466 467 468 469 470 471 472 474 476 477 478 479 480 481 482 483 484 485 486 487 489 490 491 492 493 494 496 497 498 499 500 501 502 504 505 506 507 508 509 510 511 512 515 516 517 518 519 520 521 522 523 525 526 527 528 529 530 531 532 533 534 535 536 537 538 540 542 543 544 545 546 547 548 550 551 552 553 554 555 556 557 558 559 560 561 563 564 565 567 568 569 570 571 572 573 574 575 577 578 579 580 581 583 584 585 586 587 588 590 591 592 593 594 595 596 598 599 600 601 602 604 605 606 607 608 609 610 611 612 613 614 615 617 618 619 620 621 622 624 625 626 628 629 630 631 632 633 634 635 636 637 638 639 640 642 643 645 646 647 648 649 650 651 652 653 654 655 656 657 658 660 661 662 664 665 666 667 668 669 670 671 672 674 675 676 677 679 680 681 682 683 684 685 686 687 688 689 691 692 693 694 695 696 697 698 700 701 702 703 704 705 706 708 709 710 711 713 714 715 716 717 718 719 720 721 722 723 724 725 726 728 729 730 731 732 733 734 735 737 738 739 740 741 742 743 744 745 747 749 750 751 752 753 754 755 756 757 758 759 760 761 762 763 765 766 767 768 769 770 771 773 774 775 776 777 778 779 780 782 783 784 785 786 788 789 790 791 792 793 794 795 796 797 798 799 800 802 803 804 806 807 808 809 810 811 812 813 814 815 817 818 819 820 821 822 823 824 825 826 827 828 830 831 832 834 835 836 837 838 839 840 841 842 844 845 846 847 848 849 850 851 852 854 855 856 857 859 860 861 862 863 864 865 866 868 869 870 871 872 873 874 875 876 877 878 879 881 882 883 884 886 887 888 889 890 891 892 894 895 896 897 898 899 901 902 903 904 905 906 907 908 909 910 911 913 914 915 917 918 919 920 921 922 923 924 926 927 928 929 930 931 932 933 934 935 937 938 939 940 941 942 943 944 945 947 948 949 950 951 953 954 955 956 957 958 959 960 962 963 964 965 966 967 968 969 970 971 972 974 975 976 978 979 980 981 982 983 984 986 987 988 989 990 991 992 994 995 996 997 998 999 1000 1001 1002 1003 1005 1006 1007 1008 1009 1011 1012 1014 1015 1016 1017 1019 1020 1021 1022 1023 1024 1025 1026 1028 1029 1030 1031 1032 1033 1034 1035 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1050 1051 1052 1053 1054 1056 1057 1058 1059 1060 1062 1063 1064 1065 1066 1067 1068 1069 1070 1071 1072 1074 1075 1076 1077 1078 1080 1081 1082 1083 1084 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 1101 1103 1104 1105 1106 1107 1108 1109 1110 1112 1113 1114 1115 1116 1117 1118 1119 1120 1122 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 1136 1137 1138 1139 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1154 1155 1156 1157 1158 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 1171 1172 1173 1174 1175 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 1201 1203 1204 1205 1206 1207 1208 1209 1211 1212 1213 1214 1215 1216 1218 1219 1220 1221 1222 1223 1224 1225 1227 1228 1229 1231 1232 1233 1234 1235 1236 1237 1238 1239 1240 1241 1242 1244 1245 1246 1247 1248 1249 1251 1252 1253 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1268 1269 1270 1272 1273 1274 1275 1276 1277 1278 1279 1280 1281 1282 1284 1285 1286 1287 1288 1289 1290 1291 1292 1294 1295 1296 1297 1298 1299 1300 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1313 1314 1315 1316 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1331 1332 1333 1334 1335 1336 1337 1338 1339 1341 1342 1343 1344 1345 1346 1347 1349 1350 1351 1352 1353 1354 1355 1357 1358 1359 1360 1361 1363 1364 1365 1366 1367 1368 1369 1370 1371 1373 1374 1375 1376 1377 1378 1379 1380 1382 1383	
NALTREXONE	2	0 1	
THERAPY	2	0 1	

Number of Observations Read	4904	
Number of Observations Used	4712	

Dimensions	
G-side Cov. Parameters	3	
R-side Cov. Parameters	1	
Columns in X	18	
Columns in Z per Subject	2	
Subjects (Blocks in V)	1226	
Max Obs per Subject	4	

Optimization Information	
Optimization Technique	Dual Quasi-Newton	
Parameters in Optimization	12	
Lower Boundaries	3	
Upper Boundaries	0	
Fixed Effects	Not Profiled	
Starting From	GLM estimates	
Quadrature Points	5	

Iteration History	
Iteration	Restarts	Evaluations	Objective
Function	Change	Max
Gradient	
0	0	4	24147.168303	.	5891.853	
1	0	3	23302.756978	844.41132518	846.4801	
2	0	5	23201.792524	100.96445355	384.4697	
3	0	2	23122.32435	79.46817467	1348.965	
4	0	3	23064.672577	57.65177262	656.9726	
5	0	2	23050.223214	14.44936264	376.5065	
6	0	2	23032.001172	18.22204204	213.7	
7	0	5	23024.45444	7.54673286	311.1051	
8	0	4	22994.297581	30.15685841	329.055	
9	0	2	22963.487296	30.81028518	242.4074	
10	0	2	22954.374513	9.11278260	525.0333	
11	0	4	22931.416949	22.95756474	120.3053	
12	0	5	22928.921193	2.49575544	459.5003	
13	0	2	22924.692137	4.22905659	162.2295	
14	0	3	22922.852606	1.83953083	59.49892	
15	0	2	22920.490842	2.36176354	127.9787	
16	0	2	22916.673348	3.81749388	51.62855	
17	0	3	22915.819076	0.85427226	30.02877	
18	0	3	22915.251627	0.56744956	38.09691	
19	0	2	22914.34466	0.90696620	22.09037	
20	0	3	22913.750808	0.59385249	10.98263	
21	0	3	22913.687073	0.06373507	1.632143	
22	0	3	22913.682383	0.00468993	1.919106	
23	0	2	22913.675499	0.00688431	2.55091	
24	0	4	22913.649169	0.02632913	8.332695	
25	0	2	22913.603877	0.04529280	7.420391	
26	0	2	22913.55657	0.04730647	6.583487	
27	0	2	22913.537351	0.01921932	4.492909	
28	0	2	22913.518569	0.01878180	1.78579	
29	0	3	22913.516402	0.00216702	1.592074	
30	0	4	22913.509749	0.00665342	2.278543	
31	0	2	22913.498521	0.01122808	0.905567	
32	0	3	22913.495953	0.00256760	0.149394	
33	0	3	22913.495924	0.00002881	0.009799	

Convergence criterion (GCONV=1E-8) satisfied.	

Fit Statistics	
-2 Log Likelihood	22913.50	
AIC  (smaller is better)	22937.50	
AICC (smaller is better)	22937.56	
BIC  (smaller is better)	22998.83	
CAIC (smaller is better)	23010.83	
HQIC (smaller is better)	22960.58	

Fit Statistics for Conditional Distribution	
-2 log L(ndr | r. effects)	16667.25	
Pearson Chi-Square	2549.33	
Pearson Chi-Square / DF	0.54	

Covariance Parameter Estimates	
Cov Parm	Subject	Estimate	Standard Error	
UN(1,1)	ID_COMB	3.8963	0.2875	
UN(2,1)	ID_COMB	-0.1340	0.04842	
UN(2,2)	ID_COMB	0.1305	0.01169	
Scale		0.1020	0.01004	

Solutions for Fixed Effects	
Effect	NALTREXONE	THERAPY	Estimate	Standard Error	DF	t Value	Pr > |t|	
Intercept			-2.5061	0.1343	1216	-18.66	<.0001	
NALTREXONE	0		-0.1199	0.1820	2310	-0.66	0.5100	
NALTREXONE	1		0	.	.	.	.	
THERAPY		0	-0.3024	0.1840	2310	-1.64	0.1006	
THERAPY		1	0	.	.	.	.	
NALTREXONE*THERAPY	0	0	0.3819	0.2585	2310	1.48	0.1398	
NALTREXONE*THERAPY	0	1	0	.	.	.	.	
NALTREXONE*THERAPY	1	0	0	.	.	.	.	
NALTREXONE*THERAPY	1	1	0	.	.	.	.	
month			-0.09050	0.03398	1178	-2.66	0.0078	
month*NALTREXONE	0		0.06729	0.04253	2310	1.58	0.1137	
month*NALTREXONE	1		0	.	.	.	.	
month*THERAPY		0	0.06383	0.04336	2310	1.47	0.1411	
month*THERAPY		1	0	.	.	.	.	
month*NALTRE*THERAPY	0	0	0.003216	0.06018	2310	0.05	0.9574	
month*NALTRE*THERAPY	0	1	0	.	.	.	.	
month*NALTRE*THERAPY	1	0	0	.	.	.	.	
month*NALTRE*THERAPY	1	1	0	.	.	.	.	

Type III Tests of Fixed Effects	
Effect	Num DF	Den DF	F Value	Pr > F	
NALTREXONE	1	2310	0.30	0.5831	
THERAPY	1	2310	0.74	0.3888	
NALTREXONE*THERAPY	1	2310	2.18	0.1398	
month	1	1178	1.31	0.2535	
month*NALTREXONE	1	2310	5.22	0.0224	
month*THERAPY	1	2310	4.73	0.0297	
month*NALTRE*THERAPY	1	2310	0.00	0.9574	

Estimates	
Label	Estimate	Standard Error	DF	t Value	Pr > |t|	Alpha	Lower	Upper	Exponentiated
Estimate	
Slope for no CBI group	0.008588	0.02590	2310	0.33	0.7402	0.05	-0.04220	0.05938	1.0086	
Slope for CBI group	-0.05685	0.02596	2310	-2.19	0.0286	0.05	-0.1078	-0.00594	0.9447	
Slope for placebo group	0.01032	0.02508	2310	0.41	0.6808	0.05	-0.03886	0.05949	1.0104	
Slope for naltrexone group	-0.05858	0.02680	2310	-2.19	0.0289	0.05	-0.1111	-0.00603	0.9431	
Difference in slopes: no CBI vs CBI	0.06544	0.03009	2310	2.17	0.0297	0.05	0.006434	0.1244	1.0676	
Difference in slope:placebo vs naltrexone	0.06890	0.03015	2310	2.29	0.0224	0.05	0.009771	0.1280	1.0713	

Estimates	
Label	Exponentiated
Lower	Exponentiated
Upper	
Slope for no CBI group	0.9587	1.0612	
Slope for CBI group	0.8978	0.9941	
Slope for placebo group	0.9619	1.0613	
Slope for naltrexone group	0.8948	0.9940	
Difference in slopes: no CBI vs CBI	1.0065	1.1325	
Difference in slope:placebo vs naltrexone	1.0098	1.1366	

Treatment_group	month	N Obs	Variable	Label	N	Mean	Std Dev	Minimum	Maximum	
1.Naltrexone + CBI	1	312	ndr
predicted	
Mu	309
309	6.4142395
6.6116878	8.3029054
7.8777098	0
0.2011350	28.0000000
27.7010198	
	2	312	ndr
predicted	
Mu	297
297	6.9696970
6.3269747	8.8146698
7.6180934	0
0.1662771	28.0000000
27.2578199	
	3	312	ndr
predicted	
Mu	295
295	6.5661017
6.2632788	8.6834860
7.8027569	0
0.0079552	28.0000000
27.4500402	
	4	312	ndr
predicted	
Mu	290
290	6.5482759
6.6724364	8.8164333
8.4335058	0
0.1086907	28.0000000
30.3419838	
2.Naltrexone	1	302	ndr
predicted	
Mu	302
302	5.0463576
5.3288387	6.8368143
6.5748513	0
0.0489002	28.0000000
26.4984712	
	2	302	ndr
predicted	
Mu	293
293	6.0716724
5.3502133	8.3003332
6.6859962	0
0.0385760	28.0000000
27.0322378	
	3	302	ndr
predicted	
Mu	286
286	6.2377622
5.8207394	8.8229828
7.6294803	0
0.1390403	28.0000000
27.5767562	
	4	302	ndr
predicted	
Mu	283
283	6.2756184
6.5648515	8.9530893
9.1976646	0
0.1101759	28.0000000
35.3368971	
3.CBI	1	307	ndr
predicted	
Mu	305
305	5.6065574
5.8154685	7.5150697
7.0726516	0
0.1744301	28.0000000
26.5821049	
	2	307	ndr
predicted	
Mu	294
294	6.5714286
5.9029353	8.3469968
7.0497458	0
0.0544016	28.0000000
27.0903205	
	3	307	ndr
predicted	
Mu	291
291	6.5463918
6.2580490	8.4396690
7.5488162	0
0.1469117	28.0000000
27.6082525	
	4	307	ndr
predicted	
Mu	289
289	6.7577855
6.9753097	8.8676701
8.8626061	0
0.1215517	28.0000000
34.0292930	
4.Neither	1	305	ndr
predicted	
Mu	304
304	6.3782895
6.6525073	7.7824158
7.3834132	0
0.1888547	28.0000000
27.4227260	
	2	305	ndr
predicted	
Mu	298
298	7.9697987
7.1956339	9.1652851
7.7970334	0
0.0747367	28.0000000
26.9963565	
	3	305	ndr
predicted	
Mu	291
291	8.3092784
7.8743983	9.5100972
8.5603590	0
0.1622548	28.0000000
27.7936777	
	4	305	ndr
predicted	
Mu	285
285	8.7543860
9.1331321	9.8024154
10.0289775	0
0.1503946	28.0000000
33.4278391	

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	
Prm1	Intercept			
Prm2	NALTREXONE	0		
Prm3	NALTREXONE	1		
Prm4	THERAPY		0	
Prm5	THERAPY		1	
Prm6	NALTREXONE*THERAPY	0	0	
Prm7	NALTREXONE*THERAPY	0	1	
Prm8	NALTREXONE*THERAPY	1	0	
Prm9	NALTREXONE*THERAPY	1	1	
Prm10	month			
Prm11	month*NALTREXONE	0		
Prm12	month*NALTREXONE	1		
Prm13	month*THERAPY		0	
Prm14	month*THERAPY		1	
Prm15	month*NALTRE*THERAPY	0	0	
Prm16	month*NALTRE*THERAPY	0	1	
Prm17	month*NALTRE*THERAPY	1	0	
Prm18	month*NALTRE*THERAPY	1	1	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Exchangeable	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Covariance Matrix (Model-Based)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm13	Prm15	
Prm1	0.005901	-0.005901	-0.005901	0.005901	-0.000590	0.0005896	0.0005896	-0.000590	
Prm2	-0.005901	0.01194	0.005901	-0.01194	0.0005896	-0.001196	-0.000590	0.001196	
Prm4	-0.005901	0.005901	0.01205	-0.01205	0.0005896	-0.000590	-0.001210	0.001210	
Prm6	0.005901	-0.01194	-0.01205	0.02410	-0.000590	0.001196	0.001210	-0.002424	
Prm10	-0.000590	0.0005896	0.0005896	-0.000590	0.0002430	-0.000243	-0.000243	0.0002430	
Prm11	0.0005896	-0.001196	-0.000590	0.001196	-0.000243	0.0004883	0.0002430	-0.000488	
Prm13	0.0005896	-0.000590	-0.001210	0.001210	-0.000243	0.0002430	0.0004937	-0.000494	
Prm15	-0.000590	0.001196	0.001210	-0.002424	0.0002430	-0.000488	-0.000494	0.0009836	

Covariance Matrix (Empirical)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm13	Prm15	
Prm1	0.006506	-0.006506	-0.006506	0.006506	-0.000912	0.0009120	0.0009120	-0.000912	
Prm2	-0.006506	0.01364	0.006506	-0.01364	0.0009120	-0.001992	-0.000912	0.001992	
Prm4	-0.006506	0.006506	0.01385	-0.01385	0.0009120	-0.000912	-0.001989	0.001989	
Prm6	0.006506	-0.01364	-0.01385	0.02687	-0.000912	0.001992	0.001989	-0.003859	
Prm10	-0.000912	0.0009120	0.0009120	-0.000912	0.0004131	-0.000413	-0.000413	0.0004131	
Prm11	0.0009120	-0.001992	-0.000912	0.001992	-0.000413	0.0008699	0.0004131	-0.000870	
Prm13	0.0009120	-0.000912	-0.001989	0.001989	-0.000413	0.0004131	0.0009316	-0.000932	
Prm15	-0.000912	0.001992	0.001989	-0.003859	0.0004131	-0.000870	-0.000932	0.001687	

Algorithm converged.	

Working Correlation Matrix	
	Col1	Col2	Col3	Col4	
Row1	1.0000	0.7823	0.7823	0.7823	
Row2	0.7823	1.0000	0.7823	0.7823	
Row3	0.7823	0.7823	1.0000	0.7823	
Row4	0.7823	0.7823	0.7823	1.0000	

Exchangeable Working Correlation	
Correlation	0.7822662885	

GEE Fit Criteria	
QIC	-154079.0257	
QICu	-154092.0570	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept			-1.4229	0.0807	-1.5810	-1.2648	-17.64	<.0001	
NALTREXONE	0		-0.1800	0.1168	-0.4089	0.0489	-1.54	0.1232	
NALTREXONE	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0		-0.2893	0.1177	-0.5199	-0.0587	-2.46	0.0140	
THERAPY	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0	0.3818	0.1639	0.0606	0.7031	2.33	0.0198	
NALTREXONE*THERAPY	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
month			-0.0037	0.0203	-0.0435	0.0361	-0.18	0.8555	
month*NALTREXONE	0		0.0559	0.0295	-0.0019	0.1137	1.90	0.0581	
month*NALTREXONE	1		0.0000	0.0000	0.0000	0.0000	.	.	
month*THERAPY	0		0.0780	0.0305	0.0182	0.1378	2.56	0.0106	
month*THERAPY	1		0.0000	0.0000	0.0000	0.0000	.	.	
month*NALTRE*THERAPY	0	0	-0.0348	0.0411	-0.1153	0.0457	-0.85	0.3963	
month*NALTRE*THERAPY	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
month*NALTRE*THERAPY	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
month*NALTRE*THERAPY	1	1	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	0.02	0.8948	
THERAPY	1	1.41	0.2351	
NALTREXONE*THERAPY	1	5.32	0.0211	
month	1	24.78	<.0001	
month*NALTREXONE	1	3.29	0.0698	
month*THERAPY	1	8.02	0.0046	
month*NALTRE*THERAPY	1	0.67	0.4125	

Contrast Estimate Results	
Label	Mean Estimate	Mean	L'Beta Estimate	Standard Error	Alpha	L'Beta	Chi-Square	Pr > ChiSq	
		Confidence Limits				Confidence Limits			
Slope when no CBI is given	1.0885	1.0585	1.1195	0.0848	0.0143	0.05	0.0568	0.1129	35.22	<.0001	
Exp(Slope when no CBI is given)				1.0885	0.0156	0.05	1.0585	1.1195			
Slope when CBI is given	1.0245	0.9954	1.0546	0.0242	0.0147	0.05	-0.0047	0.0532	2.70	0.1001	
Exp(Slope when CBI is given)				1.0245	0.0151	0.05	0.9954	1.0546			
Slope on placebo	1.0766	1.0480	1.1060	0.0738	0.0137	0.05	0.0468	0.1007	28.81	<.0001	
Exp(Slope on placebo)				1.0766	0.0148	0.05	1.0480	1.1060			
Slope on naltrexone	1.0359	1.0054	1.0674	0.0353	0.0153	0.05	0.0054	0.0652	5.35	0.0207	
Exp(Slope on naltrexone)				1.0359	0.0158	0.05	1.0054	1.0674			
Difference in slopes: no CBI vs CBI	1.0625	1.0205	1.1061	0.0606	0.0205	0.05	0.0203	0.1008	8.70	0.0032	
Exp(Difference in slopes: no CBI vs CBI)				1.0625	0.0218	0.05	1.0205	1.1061			
Difference in slope:placebo vs naltrexone	1.0392	0.9982	1.0819	0.0385	0.0205	0.05	-0.0018	0.0787	3.51	0.0610	
Exp(Difference in slope:placebo vs naltrexone)				1.0392	0.0213	0.05	0.9982	1.0819			

Model Information	
Data Set	WORK.LONG	
Distribution	Negative Binomial	
Link Function	Log	
Dependent Variable	ndr	
Offset Variable	offset	

Number of Observations Read	4904	
Number of Observations Used	4712	
Missing Values	192	

Class Level Information	
Class	Levels	Values	
ID_COMB	1226	1 2 3 4 5 6 7 8 10 11 12 14 15 16 17 18 19 20 21 22 23 24 25 27 28 29 30 31 32 33 34 35 36 37 38 40 41 42 43 44 46 47 48 49 50 51 52 54 55 56 58 59 60 61 62 63 64 65 66 68 69 70 71 72 73 74 75 76 78 79 80 82 83 84 85 86 87 88 89 90 92 93 94 95 97 98 99 ...	
NALTREXONE	2	0 1	
THERAPY	2	0 1	

Parameter Information	
Parameter	Effect	NALTREXONE	THERAPY	
Prm1	Intercept			
Prm2	NALTREXONE	0		
Prm3	NALTREXONE	1		
Prm4	THERAPY		0	
Prm5	THERAPY		1	
Prm6	NALTREXONE*THERAPY	0	0	
Prm7	NALTREXONE*THERAPY	0	1	
Prm8	NALTREXONE*THERAPY	1	0	
Prm9	NALTREXONE*THERAPY	1	1	
Prm10	month			
Prm11	month*NALTREXONE	0		
Prm12	month*NALTREXONE	1		
Prm13	month*THERAPY		0	
Prm14	month*THERAPY		1	
Prm15	month*NALTRE*THERAPY	0	0	
Prm16	month*NALTRE*THERAPY	0	1	
Prm17	month*NALTRE*THERAPY	1	0	
Prm18	month*NALTRE*THERAPY	1	1	

Algorithm converged.	

GEE Model Information	
Correlation Structure	Unstructured	
Subject Effect	ID_COMB (1226 levels)	
Number of Clusters	1226	
Clusters With Missing Values	80	
Correlation Matrix Dimension	4	
Maximum Cluster Size	4	
Minimum Cluster Size	0	

Covariance Matrix (Model-Based)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm13	Prm15	
Prm1	0.007169	-0.007169	-0.007169	0.007169	-0.001045	0.001045	0.001045	-0.001045	
Prm2	-0.007169	0.01450	0.007169	-0.01450	0.001045	-0.002113	-0.001045	0.002113	
Prm4	-0.007169	0.007169	0.01463	-0.01463	0.001045	-0.001045	-0.002135	0.002135	
Prm6	0.007169	-0.01450	-0.01463	0.02926	-0.001045	0.002113	0.002135	-0.004267	
Prm10	-0.001045	0.001045	0.001045	-0.001045	0.0004358	-0.000436	-0.000436	0.0004358	
Prm11	0.001045	-0.002113	-0.001045	0.002113	-0.000436	0.0008752	0.0004358	-0.000875	
Prm13	0.001045	-0.001045	-0.002135	0.002135	-0.000436	0.0004358	0.0008845	-0.000885	
Prm15	-0.001045	0.002113	0.002135	-0.004267	0.0004358	-0.000875	-0.000885	0.001761	

Covariance Matrix (Empirical)	
	Prm1	Prm2	Prm4	Prm6	Prm10	Prm11	Prm13	Prm15	
Prm1	0.006637	-0.006637	-0.006637	0.006637	-0.001004	0.001004	0.001004	-0.001004	
Prm2	-0.006637	0.01372	0.006637	-0.01372	0.001004	-0.002069	-0.001004	0.002069	
Prm4	-0.006637	0.006637	0.01403	-0.01403	0.001004	-0.001004	-0.002109	0.002109	
Prm6	0.006637	-0.01372	-0.01403	0.02714	-0.001004	0.002069	0.002109	-0.004000	
Prm10	-0.001004	0.001004	0.001004	-0.001004	0.0004918	-0.000492	-0.000492	0.0004918	
Prm11	0.001004	-0.002069	-0.001004	0.002069	-0.000492	0.0009538	0.0004918	-0.000954	
Prm13	0.001004	-0.001004	-0.002109	0.002109	-0.000492	0.0004918	0.001014	-0.001014	
Prm15	-0.001004	0.002069	0.002109	-0.004000	0.0004918	-0.000954	-0.001014	0.001787	

Algorithm converged.	

Working Correlation Matrix	
	Col1	Col2	Col3	Col4	
Row1	1.0000	0.7983	0.6683	0.6237	
Row2	0.7983	1.0000	0.9089	0.8195	
Row3	0.6683	0.9089	1.0000	0.9049	
Row4	0.6237	0.8195	0.9049	1.0000	

GEE Fit Criteria	
QIC	-142649.5560	
QICu	-142660.7960	

Analysis Of GEE Parameter Estimates	
Empirical Standard Error Estimates	
Parameter		Estimate	Standard Error	95% Confidence Limits	Z	Pr > |Z|	
Intercept			-1.4328	0.0815	-1.5925	-1.2732	-17.59	<.0001	
NALTREXONE	0		-0.1765	0.1171	-0.4061	0.0530	-1.51	0.1318	
NALTREXONE	1		0.0000	0.0000	0.0000	0.0000	.	.	
THERAPY	0		-0.2734	0.1184	-0.5055	-0.0413	-2.31	0.0210	
THERAPY	1		0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	0	0	0.3776	0.1647	0.0547	0.7005	2.29	0.0219	
NALTREXONE*THERAPY	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
NALTREXONE*THERAPY	1	1	0.0000	0.0000	0.0000	0.0000	.	.	
month			-0.0123	0.0222	-0.0557	0.0312	-0.55	0.5796	
month*NALTREXONE	0		0.0524	0.0309	-0.0082	0.1129	1.70	0.0899	
month*NALTREXONE	1		0.0000	0.0000	0.0000	0.0000	.	.	
month*THERAPY	0		0.0649	0.0318	0.0025	0.1274	2.04	0.0414	
month*THERAPY	1		0.0000	0.0000	0.0000	0.0000	.	.	
month*NALTRE*THERAPY	0	0	-0.0278	0.0423	-0.1107	0.0551	-0.66	0.5110	
month*NALTRE*THERAPY	0	1	0.0000	0.0000	0.0000	0.0000	.	.	
month*NALTRE*THERAPY	1	0	0.0000	0.0000	0.0000	0.0000	.	.	
month*NALTRE*THERAPY	1	1	0.0000	0.0000	0.0000	0.0000	.	.	

Score Statistics For Type 3 GEE Analysis	
Source	DF	Chi-Square	Pr > ChiSq	
NALTREXONE	1	0.02	0.8819	
THERAPY	1	1.06	0.3035	
NALTREXONE*THERAPY	1	5.24	0.0221	
month	1	5.27	0.0218	
month*NALTREXONE	1	3.44	0.0635	
month*THERAPY	1	6.00	0.0143	
month*NALTRE*THERAPY	1	0.45	0.5044	

Contrast Estimate Results	
Label	Mean Estimate	Mean	L'Beta Estimate	Standard Error	Alpha	L'Beta	Chi-Square	Pr > ChiSq	
		Confidence Limits				Confidence Limits			
Slope when no CBI is given	1.0671	1.0373	1.0977	0.0650	0.0144	0.05	0.0367	0.0932	20.24	<.0001	
Exp(Slope when no CBI is given)				1.0671	0.0154	0.05	1.0373	1.0977			
Slope when CBI is given	1.0140	0.9838	1.0452	0.0139	0.0154	0.05	-0.0164	0.0442	0.81	0.3678	
Exp(Slope when CBI is given)				1.0140	0.0157	0.05	0.9838	1.0452			
Slope on placebo	1.0604	1.0319	1.0897	0.0587	0.0139	0.05	0.0314	0.0859	17.81	<.0001	
Exp(Slope on placebo)				1.0604	0.0147	0.05	1.0319	1.0897			
Slope on naltrexone	1.0204	0.9890	1.0527	0.0202	0.0159	0.05	-0.0110	0.0514	1.61	0.2049	
Exp(Slope on naltrexone)				1.0204	0.0162	0.05	0.9890	1.0527			
Difference in slopes: no CBI vs CBI	1.0524	1.0097	1.0969	0.0510	0.0211	0.05	0.0096	0.0925	5.83	0.0157	
Exp(Difference in slopes: no CBI vs CBI)				1.0524	0.0222	0.05	1.0097	1.0969			
Difference in slope:placebo vs naltrexone	1.0392	0.9971	1.0832	0.0385	0.0211	0.05	-0.0029	0.0799	3.31	0.0687	
Exp(Difference in slope:placebo vs naltrexone)				1.0392	0.0220	0.05	0.9971	1.0832			

Analysis Variable : predicted Predicted Value	
Treatment_group	month	N Obs	N	Mean	Std Dev	Minimum	Maximum	
1.Naltrexone + CBI	1	312	309	6.4803472	0.6818590	1.4143100	6.6001135	
	2	312	297	6.4983716	0.2991338	1.3970441	6.5195389	
	3	312	295	6.3495081	0.6910870	0.2299981	6.4399480	
	4	312	290	6.3550614	0.0623682	5.4525675	6.3613287	
2.Naltrexone	1	302	302	5.2599635	0.5852611	0.1913636	5.3581799	
	2	302	293	5.5563302	0.5572572	0.6051312	5.6478915	
	3	302	286	5.9242744	0.2815281	2.3387837	5.9532676	
	4	302	283	6.2078421	0.5626561	0.4482254	6.2751551	
3.CBI	1	307	305	5.7373077	0.5126549	1.4573649	5.8294595	
	2	307	294	6.0252082	0.4253171	0.8668516	6.0679611	
	3	307	291	6.2999415	0.1724508	4.2860067	6.3162205	
	4	307	289	6.5405125	0.2808092	3.7569354	6.5746369	
4.Neither	1	305	304	6.6544127	0.4487280	1.4387919	6.7143624	
	2	305	298	7.1884063	0.5535634	1.0362293	7.2536053	
	3	305	291	7.7467152	0.6967127	0.8395881	7.8361558	
	4	305	285	8.4219977	0.4211637	2.1163730	8.4654921